[Clinical evaluation of Er:YAG laser in the treatment of grade Ⅱ periodontitis with bifurcation lesions].

Purpose: To evaluate the clinical efficacy of erbium-doped yttrium aluminium garnet (Er: YAG) laser in the treatment of degree II bifurcation periodontitis.

Methods: Thirty patients(60 teeth) with grade II bifurcation lesions of chronic periodontitis were enrolled in this study. One week after supergingival scaling with ultrasound, the patients were randomly divided into experimental group: subgingival scaling with ultrasound and hand instruments + Er: YAG laser irradiation in periodontal pocket; control group: the contralateral homonymous teeth were treated with subgingival scaling with ultrasound and hand instruments alone.

The inhibitory effect of the deubiquitinase cylindromatosis (CYLD) on inflammatory responses in human gingival fibroblasts.

Objective: Experiments were performed to evaluate CYLD expression in human gingival tissue samples and to examine the effects of CYLD on inflammatory responses in lipopolysaccharide (LPS)- or TNF-α-stimulated human gingival fibroblasts (HGFs).

Methods: Immunohistochemistry for CYLD and p65 expression was performed with healthy and inflamed gingival tissue samples. siRNA was used to knock down the expression of CYLD in HGFs.

AGEs induces apoptosis and autophagy via reactive oxygen species in human periodontal ligament cells.

The apoptosis of human periodontal ligament cells (HPDLCs) may be an important factor of the negative effect of advanced glycation end products (AGEs) on the periodontal tissue of diabetic patients. However, the pathways or potential effects of apoptosis in AGEs-treated HPDLCs have not been fully elucidated. Autophagy is closely related to apoptosis.

M1 macrophages regulate TLR4/AP1 via paracrine to promote alveolar bone destruction in periodontitis.

Objective: Macrophages could be fully polarized and acquire specific phenotype like M1, which considered to be essential for the alveolar bone destruction during the development of periodontitis. However, the molecular mechanisms underlying the effects of M1 macrophages on the alveolar bone destruction are still not clear yet.

Methods: Mouse periodontitis model was established to determine the involvement of M1 macrophages in the pathogenic process.

[Correlation between hyperglycemia levels and periodontitis in 545 officeholders in Nantong city].

Purpose: To identify the relationship between hyperglycemia levels and periodontitis by investigating the levels of hyperglycemia and periodontal conditions of officeholders in Nantong city.

Methods: From January 2013 to January 2014, 545 officeholders were randomly selected in Nantong City who underwent physical examination and divided into 2 groups: young of middle-aged adults(≤60 years) and old adults (>60 years). The data was analyzed with Chi-square test and multi-factors logistic regression by using SPSS 16.