Two new sixteen-membered macrolides from the genetically engineered strain MHJ1011.

Two new sixteen-membered macrolides, Δ-tenvermectin A () and 13-hydroxy milbemycin (), were isolated from the fermentation broth of the genetically engineered strain MHJ1011. Their structures were determined based on extensive spectroscopic analysis and comparison with related known compounds. Compounds and exhibited potent acaricidal activity against .

Constructing the Architecturally Distinctive ABD-Tricycle of Phomactin A through an Intramolecular [3 + 3] Annulation Strategy.

Our efforts in constructing the ABD-ring of phomactin A through an intramolecular -[3 + 3] annulation strategy is described. This struggle entailed finding a practical and efficient preparation of annulation precursor, and a realization of the unexpected competing regioisomeric pathway. The success entailed accessing the A-ring through Diels-Alder cycloaddition of Rawal's diene.

An Enantioselective Synthesis of the ABD Tricycle for (-)-Phomactin A Featuring Rawal's Asymmetric Diels-Alder Cycloaddition.

An enantioselective synthesis of the ABD-ring of (-)-phomactin A is described here. The sequence features Rawal's asymmetric Diels-Alder cycloaddition. The overall length is significantly reduced from our previous attempt.

An Enantioselective Synthesis of the ABD Tricycle for (-)-Phomactin A Featuring Rawal's Asymmetric Diels-Alder Cycloaddition.

An enantioselective synthesis of the ABD-ring of (-)-phomactin A is described here. The sequence features Rawal's asymmetric Diels-Alder cycloaddition. The overall length is significantly reduced from our previous attempt.