Publications by authors named "You-Lin Qiao"
Background: There are scarce data on risk factors for epithelial ovarian cancer (EOC) in Asian populations. Our goal was to advance knowledge on reproductive -related risk factors for EOC in a large population of Asian women.
Methods: This study used pooled individual data from baseline questionnaires in 11 prospective cohorts (baseline years, 1958-2015) in the Asia Cohort Consortium.
Background: It has been suggested that the association between body mass index and breast cancer risk differs between Asian women and Western women. We aimed to assess the associations between body mass index and breast cancer incidence in East Asian women.
Methods: Pooled analyses were performed using individual participant data of 319,189 women from 13 cohort studies in Japan, Korea, and China.
Article Synopsis
- * Researchers found that the average age girls start their periods is about 14 years, but it has been getting younger over the past 100 years.
- * Different countries showed different trends, with some like China having ups and downs, while others like Japan and Singapore had a steady decline in the average age.
Article Synopsis
- A study examined the impact of family history of lung cancer (FHLC) on lung cancer incidence and mortality among East Asian individuals, using data from 478,354 participants across 11 cohorts.
- The findings indicated that having a family history of lung cancer increased the risk of developing lung cancer by 45%, affecting both men and women, and regardless of whether individuals were smokers or non-smokers.
- Specific lung cancer types like adenocarcinoma and squamous cell carcinoma showed even higher associated risks, but there was no significant difference in risk based on sex, smoking status, or ethnicity.
Importance: The global burden of obesity is increasing, as are colorectal cancer (CRC) incidence and mortality.
Objectives: To assess the association between body mass index (BMI) and risks of incident CRC and CRC-related death in the Asian population.
Design, Setting, And Participants: This cohort study includes data pooled from 17 prospective cohort studies included in The Asia Cohort Consortium.
Rationale And Objective: There is a notable absence of robust evidence on the efficacy of ultrasound-based breast cancer screening strategies, particularly in populations with a high prevalence of dense breasts. Our study addresses this gap by evaluating the effectiveness of such strategies in Chinese women, thereby enriching the evidence base for identifying the most efficacious screening approaches for women with dense breast tissue.
Methods: Conducted from October 2018 to August 2022 in Central China, this prospective cohort study enrolled 8996 women aged 35-64 years, divided into two age groups (35-44 and 45-64 years).
Background: This study aimed to assess the effectiveness of high-risk human papillomavirus (HR-HPV) primary testing for cervical cancer screening in China's rural areas.
Methods: Women aged 21-64 years were recruited. Cervical cytology was diagnosed following the Bethesda 2001 classification system, HPV infection (HR-HPV, HPV-16, HPV-18, and other 12 genotypes) identified by Cobas-4800, and colposcopy and biopsy performed when required.
Background: Evidence suggests a possible link between diabetes and gastric cancer risk, but the findings remain inconclusive, with limited studies in the Asian population. We aimed to assess the impact of diabetes and diabetes duration on the development of gastric cancer overall, by anatomical and histological subtypes.
Methods: A pooled analysis was conducted using 12 prospective studies included in the Asia Cohort Consortium.
Article Synopsis
- A study was conducted using data from 968,738 adults across 20 cohort studies in Asia to investigate the link between diabetes and liver cancer incidence and mortality.
- The findings revealed that adults with diabetes had a significantly higher risk of being diagnosed with liver cancer (hazard ratio of 1.97) and dying from it (adjusted hazard ratio of 1.97) compared to those without diabetes.
- The robust results, supported by a two-stage meta-analysis, contribute valuable evidence to the understanding of liver cancer risks among diabetic populations in Asian countries.
The female predominance of gallbladder cancer (GBC) has led to a hypothesis regarding the hormone-related aetiology of GBC. We aimed to investigate the association between female reproductive factors and GBC risk, considering birth cohorts of Asian women. We conducted a pooled analysis of 331,323 women from 12 cohorts across 4 countries (China, Japan, Korea, and Singapore) in the Asia Cohort Consortium.
View Article and Find Full Text PDFArticle Synopsis
- - The study analyzed lung cancer risk related to reproductive factors among 308,949 Asian women across four countries, finding inconsistent results in previous research.
- - Parous women (those who have given birth) were found to have a significantly lower risk of lung cancer incidence and mortality compared to nulliparous women, especially among smokers.
- - Higher ages at first childbirth were associated with decreased lung cancer risk, while hormone replacement therapy users showed a greater likelihood of developing non-small cell lung cancer. Future research is needed to explore these findings further.
Article Synopsis
- The study investigates how different birth cohorts influence the relationship between reproductive and lifestyle factors and breast cancer risk.
- It uses pooled data from 12 cohort studies and employs Cox proportional hazard regression to analyze factors like age at menarche, menopause, parity, smoking, and alcohol consumption.
- Results indicate that parity reduces breast cancer risk in older cohorts, while lifestyle factors like smoking and alcohol show stronger associations in those born in the 1950s compared to earlier cohorts.
Background: Persistent human papillomavirus (HPV) infection is a known cause of a subset of head and neck cancers (HNCs). In the last two decades, the proportion of HNCs attributable to HPV infection has increased worldwide, notably the oropharyngeal cancers. However, the trend of HPV-related HNC burden is not clearly understood yet in China.
View Article and Find Full Text PDFArticle Synopsis
- Body fatness is highlighted as a potential risk factor for biliary tract cancer (BTC), with established correlations between obesity and cholelithiasis (gallstones).
- A comprehensive analysis of data from over 905,000 participants across 21 studies in Asia found that higher body mass index (BMI) correlates with increased BTC mortality, especially in females.
- The study indicates that while obesity is linked to BTC mortality in women without gallstones, the relationship is less clear in men and when gallstones are present, suggesting complex interactions between BMI, gender, and gallstone presence.
Introduction: Although lung cancer prediction models are widely used to support risk-based screening, their performance outside Western populations remains uncertain. This study aims to evaluate the performance of 11 existing risk prediction models in multiple Asian populations and to refit prediction models for Asians.
Methods: In a pooled analysis of 186,458 Asian ever-smokers from 19 prospective cohorts, we assessed calibration (expected-to-observed ratio) and discrimination (area under the receiver operating characteristic curve [AUC]) for each model.
Article Synopsis
- The HPV vaccine is designed to help prevent cervical cancer and has been worked on in China for over 15 years.
- China is making efforts to increase HPV vaccination by developing local vaccines and setting up free vaccination programs.
- Challenges like vaccine availability, pricing, and ensuring everyone, especially girls in poorer areas and boys, have access need to be solved for better vaccination rates.
Importance: Despite evidence of an association between reproductive factors and endometrial cancer risk, prospective studies have been conducted mainly in non-Asian countries.
Objective: To assess the association between reproductive factors, such as number of deliveries, age at menarche, or menopause, and endometrial cancer risk.
Design, Setting, And Participants: This cohort study used pooled individual data from 13 prospective cohort studies conducted between 1963 and 2014 in the Asia Cohort Consortium.
Article Synopsis
- This study focused on how patients with advanced colorectal cancer participate in treatment decisions and their perceptions of treatment effectiveness.
- Data was collected from 4,533 patients across 19 hospitals using a questionnaire that noted demographics and treatment experiences between March 2020 and March 2021.
- Findings showed that patients' involvement in decision-making varied widely, influenced by demographic factors, and that self-reported treatment efficacy decreased with subsequent treatments.
Article Synopsis
- - The study involved 1,688 Chinese patients with metastatic colorectal cancer (mCRC) across 19 hospitals to investigate the use of targeted therapies and the barriers they face in accessing these treatments.
- - About 51.6% of patients began targeted therapy, with varying rates of first-, second-, and third-line treatments; common barriers included high costs and doubts about treatment effectiveness.
- - Factors making patients less likely to start targeted therapy included older age, lower education and income levels, lack of medical insurance, and having more severe health issues; addressing cost and enhancing public education could improve treatment access.
Introduction: Cytology-based triaging is commonly used to manage the care of women with positive human papillomavirus (HPV) results, but it suffers from subjectivity and a lack of sensitivity and reproducibility. The diagnostic performance of an artificial intelligence-enabled liquid-based cytology (AI-LBC) triage approach remains unclear. Here, we compared the clinical performance of AI-LBC, human cytologists and HPV16/18 genotyping at triaging HPV-positive women.
View Article and Find Full Text PDFBackground: The objective of this study was to determine the short-term and long-term effects of a nutrition intervention in using 37 years of follow-up data.
Methods: The Linxian Dysplasia Population Nutrition Intervention Trial was a randomized, double-blind, placebo-controlled trial with 7 years of intervention and 30 years of follow-up. The Cox proportional hazard model was used for analyses.
Background: This study aimed to explore the association between drinking water source and risk of upper gastrointestinal (UGI) cancer, including esophageal cancer (EC) and gastric cancer (GC), in the Linxian General Population Nutrition Intervention Trial (NIT) cohort.
Methods: In this study, we used data from the Linxian NIT cohort, which included 29,584 healthy adults aged 40 to 69 years. Subjects were enrolled in April 1986 and followed up until March 2016.
Background: Self-sampling HPV test and thermal ablation are effective tools to increase screening coverage and treatment compliance for accelerating cervical cancer elimination. We assessed the cost-effectiveness of their combined strategies to inform accessible, affordable, and acceptable cervical cancer prevention strategies.
Methods: We developed a hybrid model to evaluate costs, health outcomes, and incremental cost-effectiveness ratios (ICER) of six screen-and-treat strategies combining HPV testing (self-sampling or physician-sampling), triage modalities (HPV genotyping, colposcopy or none) and thermal ablation, from a societal perspective.
Population-based cervical cytology screening techniques are demanding and laborious and have relatively poor diagnostic accuracy. In this study, we present a cytologist-in-the-loop artificial intelligence (CITL-AI) system to improve the accuracy and efficiency of abnormal cervical squamous cell detection in cervical cancer screening. The artificial intelligence (AI) system was developed using 8000 digitalized whole slide images, including 5713 negative and 2287 positive cases.
View Article and Find Full Text PDF