Publications by authors named "You-Li Zhao"

Article Synopsis
  • Cytology is a noninvasive urine test used to detect bladder cancer and upper-tract urothelial carcinoma, but it lacks sensitivity for low-grade tumors; this study evaluates the effectiveness of biomarkers like BTA, NMP22, and Survivin for diagnosis and prognosis.
  • The research involved urine samples from 105 patients, assessing them with various tests, and followed them for up to 47 months to analyze cancer progression and recurrence.
  • The combination of Survivin, BTA, and Cytology proved to be the best diagnostic approach, offering higher sensitivity compared to cytology alone, but with lower specificity; while some biomarkers showed promise for patient outcomes, they were not strong enough to serve
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Iron is an essential metal ion in the human body and usually dysregulated in cancers. However, a comprehensive overview of the iron-related genes and their clinical relevance in cancer is lacking. In this study, we utilized the expression profiling, proteomics, and epigenetics from the Cancer Genome Atlas database to systematically characterized the alterations of iron-related genes.

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Chemotherapy is still a standard treatment of unresectable bladder cancer or distant metastases. The chemotherapy resistance always occurs after a period of treatment indicating poor prognosis. The current study aimed to explore the molecular mechanism of chemoresistance in bladder cancer cells.

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Human hemokinin-1 (h HK-1) and its truncated form h HK-1(4-11) are mammalian tachykinin peptides encoded by the TAC4 gene identified in human, and the biological functions of these peptides have not been well investigated. The tachykinins have shown immuno-regulatory activities in humans. In the present study, we investigated the effects of h HK-1 and h HK-1(4-11) on the proliferation and differentiation of a human promyelocyte leukemia cell line, HL-60.

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Rat/mouse hemokinin-1 (r/m HK-1) has been identified as a member of the tachykinin family and its effect in colonic contractile activity remains unknown. We investigated the effects and mechanisms of actions of r/m HK-1 on the mouse colonic contractile activity in vitro by comparing it with that of substance P (SP). R/m HK-1 induced substantial contractions on the circular muscle of mouse colon.

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