Publications by authors named "You-Jeong Kim"

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  • CRISPR technology has changed genome editing but faces challenges with safe and efficient delivery methods for therapeutic uses.
  • The droplet cell pincher (DCP) microfluidic system offers a solution by enabling controlled and efficient delivery of CRISPR systems into cells, using mechanisms that create openings in cell membranes.
  • DCP has shown superior performance over traditional electroporation, achieving significantly higher success rates in genetic modifications like single and double knockouts and knock-ins, making it a promising tool for future CRISPR applications.
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  • This study examined the ongoing education and social backgrounds of 77 children who received cochlear implants before age 10, focusing on their auditory performance, school placements, and peer relationships based on when they received the implants and if they had additional disabilities.
  • The early-implanted group (under 3.5 years) initially showed poorer auditory performance compared to the late-implanted group (3.5 to 10 years), but their performance became comparable after two years of using the implants.
  • Both groups had high enrollment rates in regular schools, but the early-implanted group had more children without additional needs, while those with multiple disabilities performed worse academically and had different social challenges.
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The present study investigated the chemical composition, antioxidant, antimicrobial, and anti-inflammatory activities of essential oil (EO) derived from the wild rhizomes of Atractylodes macrocephala Koidz. (AMA) growing in Qimen County (eastern China). GC/MS analysis identified fifteen compounds, representing 92.

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Objectives: This study evaluated the influence of the performance of the first cochlear implant (CI-1) on the second implant (CI-2) and the significance of inter-implant intervals in children with sequential cochlear implantation.

Method: Thirty-four patients were included for speech perception outcome and 38 patients were included for subjective hearing satisfaction in daily life in this study. The patients were classified into 3 groups according to inter-implant interval: group I, <4 years; group II, 4-7 years; group III, >7 years.

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Background: Herpes zoster (HZ) is generally thought to occur once in a lifetime and recurrence is considered to be limited to immunocompromised individuals. Although HZ recurrence rates seem to be increasing, there have been few studies exploring these rates in the general population. We investigated the recurrence rate and associated risk factors in the general population.

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  • Mulberry root bark (MRB) was extracted with methanol, revealing the ethyl acetate fraction as the most effective at reducing inflammation.
  • Compounds sanggenon B, albanol B, and sanggenon D displayed the ability to inhibit nitric oxide production in immune cells stimulated by a bacterial component.
  • Albanol B, in particular, showed strong anti-inflammatory properties by lowering levels of pro-inflammatory cytokines and reducing the expression of iNOS and COX-2, suggesting its potential for new anti-inflammatory drug development.
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Background: Cognitive impairment and brain damage in diabetes is suggested to be associated with hypoglycemia. The mechanisms of hypoglycemia-induced neural death and apoptosis are not clear and reperfusion injury may be involved. Recent studies show that glucose deprivation/reperfusion induced more neuronal cell death than glucose deprivation itself.

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[Purpose] To analyze the electromyographic (EMG) activities of several lower extremity muscles during ground walking and pedaling using the Pedalo Reha-Bar device. [Subjects and Methods] Fifteen healthy adults aged 20-29 year participated in this study. The subjects' surface EMG signals while walking and Pedalo Reha-Bar riding were recorded.

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Background: Ginsenoside Rg3 has been proposed to mediate anti-diabetic effects, but their direct effect on pancreatic β cell viability and mechanisms are not clearly understood. Recent studies suggest that intermittent high glucose (IHG) could be more harmful to pancreatic β cells than sustained high glucose. There are few reports about the effect of the ginsenosideRg3 to β cell apoptosis and proliferation against IHG.

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General epidemiological data regarding herpes zoster (HZ) are necessary for treatment and prevention of this disease. In addition, epidemiological data can play an important role in evaluating the efficacy and impact of vaccination. Though several epidemiological studies of HZ in Korea have been conducted, they usually depend on hospital-based data and may not be representative of HZ characteristics all over Korea.

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Background: In vitro experiments using only β-cell lines instead of islets are limited because pancreatic islets are composed of four different types of endocrine cells. Several recent studies have focused on cellular interactions among these cell types, especially α- and β-cells. Because islet isolation needs time and experience, we tested a simple co-culture system with α- and β-cells.

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Objective: Gastrin increases the growth and neogenesis of the islets of Langerhans. Oral proton pump inhibitors (PPIs) increase the circulating gastrin level in animals and humans, but the therapeutic benefit of PPIs for diabetes mellitus has not been resolved. We examined whether treatment with a PPI for ≥2 months affected the glycated hemoglobin (A1C) level in patients with type 2 diabetes.

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Diabetic myonecrosis-a rare complication of long-standing, poorly controlled diabetes mellitus-typically presents with acute-onset muscle pain, is self-limiting, and responds well to conservative management. We report a case of diabetic myonecrosis in a 33-year-old man with hepatitis B-induced liver cirrhosis and type 2 diabetes who presented with abdominal distension and pain in the left thigh. Diabetic myonecrosis was diagnosed based on clinical presentation, radiological findings, magnetic resonance imaging and histopathological investigations; he was successfully treated conservatively with insulin and analgesics.

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Objective: Previous studies have shown that low cardiorespiratory fitness (CRF), visceral obesity and low muscle mass may share pathophysiological mechanisms, such as insulin resistance and chronic inflammation. In this study, we investigated whether low CRF is associated with low muscle mass, visceral obesity, and visceral obesity combined with low muscle mass.

Research Design And Methods: The associations between CRF and low muscle mass and combined low muscle mass and visceral obesity were examined in 298 apparently healthy adults aged 20-70 years.

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Background: Recent studies suggested that the association of acute glucose variability and diabetic complications was not consistent, and that A1c variability representing long term glucose fluctuation may be related to coronary atherosclerosis in patients with type 1 diabetes. In this study, we attempt to determine whether or not A1c variability can predict coronary artery disease (CAD) in patients with type 2 diabetes.

Methods: We reviewed data of patients with type 2 diabetes who had undergone coronary angiography (CAG) and had been followed up with for 5 years.

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Background: The interleukin 10 deficient mice (IL-10(-/-)) showed high incidence of pup alopecia compared to other strains, and pup alopecia was caused by skin inflammation and was recoverable. Pup alopecia of B6.IL-10(-/-) might be related with maternal factor and interleukin-10 deficient phenotype.

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Aims: Adipocyte fatty acid-binding protein (A-FABP) plays a key role in obesity-related insulin resistance and inflammation which may be involved in the pathogenesis of sarcopenic obesity (SO). This study examined the association of SO with serum A-FABP levels in Korean adults.

Methods: Two hundred ninety eight adults aged 20-70 years were examined using dual X-ray absorptiometry and computed tomography and measuring serum A-FABP levels.

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A simple separation and detection system based on an electrochemical potential modulated microchannel (EPMM) device was developed for the first time. The application of alternating current (AC) potential to the microfluidic separation channel walls, which were composed of screen printed carbon electrodes, resulted in the oscillation and fluctuation of analytes and in the formation of a perfect flat flow front. These events resulted in an increase in the effective concentration and in the fine separation of samples.

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Aneurysm of the mitral valve, although uncommon, occurs most commonly in association with infective endocarditis of the aortic valve and true mitral valve aneurysm is a rare cause of mitral regurgitation. We report a case with perforated mitral valve aneurysm in the posterior leaflet without concurrent infective endocarditis initially mistaken diagnosis of cystic mass, which was confirmed at operation with successful mitral valve annuloplasty.

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'Enlarged facial pore' is a subjective term, which is not clearly defined but often complained by many. A diverse range of treatments are used though evidence of efficacy remains largely anecdotal. We report a series of nine patients who underwent a split face trial with Q-switched 1064 nm Nd:YAG and long-pulsed 1064 nm Nd:YAG laser to treat enlarged facial pores.

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Catalytic dehydropolymerization and subsequent silane-capping with R2SiHCI (R = Ph, Me) of 1,1-dihydrotetraphenylsilole (1) using various inorganic hydrides produces electroluminescent silane-capped polysiloles (2) in high yield. The polymerization yield and molecular weight increase in the order LiB[CH(CH3)C2H5]3H < NaB[CH(CH3)C2H5]3H < KB[CH(CH3)C2H5]3H. The molecular weights increase in the order Na[H2Al(OCH2CH2OCH3)2] < KB[CH(CH3)C2H5]3H < LiB(C2H5)3H.

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Background: Angiogenesis is crucial for wound healing and exogenous supplements of the angiogenic growth factors have been known to promote cutaneous wound healing. Angiopoietin (Ang) 1 is a recently discovered angiogenic factor and there have been few studies of its effect on cutaneous wound healing.

Objective: We examined the effect of Ang 1 on cutaneous wound healing.

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The dry sol-gel polycondensation at toluene in ambient air atmosphere of p-X-C6H4SiH3 (X = H, CH3, CH3O, F, Cl) to silica p-X-C6H4SiO15 in high yield, catalyzed by colloidal nickel nanoparticles in-situ generated from nickelocene(II), nickel(II) acetate, and bis(1,5-cyclooctadiene)nickel(0), is described. Similar catalytic activities were observed for the catalysts. Similarly, the dry sol-gel polyco-condensation p-X-C6H4SiH3 (X = CH3, CH3O, F, Cl):C6H4SiH3 (9:1 mole ratio) at toluene in ambient air atmosphere of was performed to yield co-silicas (p-X-C6H4SiO1.

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The combinative Si-Si/Si-O dehydrocoupling at ambient air atmosphere of 1,1-dihydrotetraphenylsilole 1 with 2 mol% of AgNO3 and Ag2SO4 in toluene at 90 degrees C produces optoelectronic polysiloles 2 in high yield. The complexes such as Cp2Co, Cp2Ni, Cp2ZrCl2/Red-Al, and AgCl were found to be ineffective for the dehydrocoupling of 1. The polysiloles mainly have Si-Si bonds along with the small portion of Si-O bonds in the polymer backbone chain.

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