Publications by authors named "You-Hua He"
Causal association of inflammation with ischemic stroke and its subtypes: a bidirectional Mendelian randomization study.
J Stroke Cerebrovasc Dis
December 2024
Background: Emerging evidence underscores a bidirectional relationship between ischemic stroke (IS) and inflammation, yet the causality of this association remains uncertain. We conducted a two-sample bidirectional Mendelian randomization (MR) study aimed at investigating the causal links between inflammation and IS.
Methods: Single nucleotide polymorphism from genome-wide association studies of 112 inflammatory cytokines and IS were chosen as instrumental variables.
Article Synopsis
- rTMS is an emerging treatment for traumatic brain injury (TBI) that enhances recovery by promoting neuroplastic changes in neurons and influencing supportive brain cells like microglia and astrocytes.
- High-frequency rTMS was tested on rats with TBI, revealing that it helps preserve neuron structure and reduce cell death by altering inflammation-related proteins in microglia and astrocytes.
- The study found that rTMS decreases harmful pro-inflammatory factors while increasing protective anti-inflammatory ones, suggesting it plays a crucial role in reducing neurological damage after TBI.
Studies have shown that repetitive transcranial magnetic stimulation (rTMS) can enhance synaptic plasticity and improve neurological dysfunction. However, the mechanism through which rTMS can improve moderate traumatic brain injury remains poorly understood. In this study, we established rat models of moderate traumatic brain injury using Feeney's weight-dropping method and treated them using rTMS.
View Article and Find Full Text PDFProstate cancer (PCa) is the sixth leading cause of cancer-related deaths in men throughout the world. This study aimed to investigate genes associated with the pathogenesis and prognosis of PCa. Data of PCa cases were obtained from public datasets and were analyzed using an integrated bioinformatics strategy.
View Article and Find Full Text PDFObjective: To investigate the effect of the non-PLC-dependent protein kinase C (PKC) pathway of parathyroid hormone (PTH) on the apoptosis and proliferation of osteoblast MC-3T3E1 cells.
Methods: MC-3T3E1 cells were seeded in 96-well plates at the density of 1.5×10(4) cells/mL and incubated for 3 day.
Objective: To evaluate the measurement of intravesical prostatic protrusion (IPP) by transabdominal ultrasonography (TAUS) in the diagnosis of benign prostatic obstruction (BPO).
Methods: We studied the clinical data of 109 BPH patients referred for lower urinary tract symptoms (LUTS) from April 2005 to December 2006. IPP was measured by TAUS, urodynamic parameters such as Qmax and PdetQmax obtained by urodynamic studies and AG values calculated.
Objective: To evaluate the efficacy of sildenafil on nocturnal penile tumescence (NPT).
Methods: Thirty-five patients with erectile dysfunction (ED), 28 cases of organic ED and 7 cases of psychogenic ED, were treated with sildenafil 100 mg before bedtime. The NPT of the patients was observed by using NEVA.