Publications by authors named "You-Gang Mai"
[Clinical Analysis of Pediatric Acute Leukemia Complicated with Septic Shock].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2022
Objective: To analyze the clinical characteristics of predictors in pediatric acute leukemia complicated with septic shock and explore the prognostic factors.
Methods: The clinical characteristics of 70 children with acute leukemia and complicated with septic shock hospitalized in Sun Yat-sen Memorial Hospital from March 2012 to March 2021 were retrospectively analyzed. The clinical characteristics of patients in survival group and death group were analyzed and compared.
[Clinical Characteristic, Diagnosis and Treatment of Acute Lymphoblastic Leukemia Combined with Pneumocystis Carinii Pneumonia in Children].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
August 2022
Article Synopsis
- The study aimed to understand the clinical features and treatments of Pneumocystis carinii pneumonia (PCP) in children with acute lymphoblastic leukemia (ALL) post-chemotherapy to enhance early diagnosis and treatment effectiveness.
- Five children with ALL who developed PCP during granulocyte deficiency were analyzed, revealing a higher incidence in males, non-specific symptoms, and elevated inflammatory markers, with all cases confirmed through laboratory testing of lung fluid.
- Treatment included stopping chemotherapy, administering antibiotics (TMP-SMX), antifungals (caspofungin), and supportive care; while four of the children recovered, one unfortunately did not survive.
Background: Immune reconstitution inflammatory syndrome (IRIS) refers to the phenomenon of intense immune responses against pathogens in patients with AIDS undergoing antiretroviral therapy to reconstitute immune function, resulting in functional impairment of multiple organs. Non-AIDS immunosuppressed hosts may also develop similar manifestations to IRIS during immune recovery.
Case Presentation: An 8-year-old girl presented with acute lymphoblastic leukaemia was admitted for scheduled chemotherapy treatment.
Thymic stromal lymphopoietin (TSLP) activates lung dendritic cells (DCs) to promote a T helper type 2 lymphocyte (Th2) response in animal models. However, the mechanism behind this process remains unclear. In this study, we investigate the role of a nuclear factor for activated T-cells 1 (NFATc1) in the TSLP-induced polarisation towards a Th2 response.
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