Bilateral visual loss after selective artery embolization in the neck for hemorrhage of malignant tumor.

Introduction And Importance: Currently, selective arterial embolization (SAE) has been widely applied for the treatment of many diseases due to its minimal invasiveness. But the complications caused by SAE can be serious.

Case Presentation: Here, we report a case of a patient who experienced bilateral blindness 4 h after selective arterial embolization (SAE).

[Isolation and identification of two new epimer from the mother liquid of megestrol acetate].

Aim: To study the impurity in the drug megestrol acetate.

Methods: Chromatography methods were used to separate the chemical constituents. Their structures were determined by NMR and MS spectral analysis.

Isolation and identification of novel impurities in spironolactone.

Three known and five new steroidal compounds as impurities in spironolactone were isolated from the enriched mother liquor by using various chromatographic methods. Their structures were elucidated by spectrometric analysis. New compounds were characterized as 3-(3,3-dimethoxy-5 alpha,7 alpha-epidithio-17beta-hydroxy-4-androstan-17 alpha-yl) propionic acid gamma-lactone (6); 3-(3-oxo-7 alpha-acetylthio-6 beta,17beta-dihydroxy-4-androsten-17 alpha-yl) propionic acid gamma-lactone (7); 7 alpha-acetylthio-17beta-20-isopropylidendioxy-21-nor-17 alpha-pregn-4-en-3-one (8); 7 alpha-acetylthio-3-oxo-pregna-4,17(20)i-dien-22-oic acid methyl ester (9) and 7 alpha-acetylthio-17-methyl-18-nor-androsta-4-en-3-one (10).

[The isolation and identification of two new epimer from the mother liquid of testosterone].

Aim: To study the impurity of the drug testosterone.

Methods: Chromatography methods were used to separate the chemical constituents. Their structures were determined by NMR and MS spectral analysis.