Hsa-circ-ACSL1 Enhances Apoptosis and Autophagy in Myocarditis Cardiomyocytes Through the miR-7-5p/XBP1 Axis.

Background: Viral myocarditis (VMC) is a common cardiovascular disease, and circular RNAs (circRNAs) have been identified to play an important role in the pathophysiology of cardiovascular disease. However, the clinical significance, biological functions, and regulatory mechanisms of circRNAs in VMC remain poorly understood. Therefore, this study explored the biological functions and regulatory mechanisms of circ-ACSL1 in VMC.

[Study on the epidemiology of congenital heart disease in Tibetan ethnic children aged from 4 to 18 living at different altitudes in Qinghai province].

Objective: The epidemiological characteristics of congenital heart disease (CHD) among Tibetan children whose age ranged from 4 to 18 at different altitude were investigated in Qinghai province.

Methods: 32 578 Tibetan children living at 2535 m, 3600 m and 4200 m were surveyed with the following 3 steps: prescreened, counterchecked and diagnosed with color Doppler. The entity distribution was then analysed and the age and gender were compared respectively.