Design and synthesis of 7-diethylaminocoumarin-based 1,3,4-oxadiazole derivatives with anti-acetylcholinesterase activities.

Twelve novel 7-diethylaminocoumarin-based 1,3,4-oxadiazole derivatives were synthesized via iodine-mediated oxidative cyclisation and confirmed by H NMR, C NMR and HRMS. The result of these derivatives' activities inhibiting acetylcholinesterase showed that and had moderate inhibitory activities with 69.19% and 65.