Publications by authors named "You-Cai Zhao"

Molten salt has been regarded as a versatile and environmental-friendly method for the material preparation and waste destruction. In this work, molten FeCl3 was utilized for the generation of magnetic biochar (MBC) derived from simultaneous activation and magnetization of biomass. The sample characterization indicated that MBC had a rough surface with BET surface area of 404 m2/g and total pore volume of 0.

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  • This study investigates the potential of long non-coding RNAs (lncRNAs) in peripheral blood as non-invasive biomarkers for acute rejection (AR) in kidney transplants.
  • Researchers analyzed lncRNA expression profiles in 150 blood samples from both pediatric and adult transplant recipients to identify differences between those experiencing AR and those who are not.
  • They identified 23 lncRNAs common to both groups that could effectively distinguish AR cases, and created a risk score using two significant lncRNAs that showed strong diagnostic performance, making them promising candidates for AR detection in kidney transplant patients.
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  • Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer in adults, and this study focused on analyzing microRNA (miRNA) expression profiles to distinguish between tumors with mutant and wild-type mutation statuses.
  • The researchers identified 33 differentially expressed miRNAs, 11 of which were significantly associated with overall survival in patients with wild-type status, contributing to a newly developed mutation-specific miRNA signature.
  • This miRNA signature, involving 11 key miRNAs, has the potential to act as a new prognostic biomarker for ccRCC patients, potentially aiding in patient management and treatment strategies.
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Antibiotic resistant genes (ARGs), an emerging contaminant, have been detected worldwide in various environments such as sediments and river. However, little is known about ARGs distribution in landfill. In this study, we investigated five ARGs [sulfonamides resistant genes (sulI and sulII), chloramphenicols resistant gene (cat), β-lactams resistant gene (bla-SHV), and tetracyclines resistant gene (tetW)] in refuse samples collected from jiangeungou landfill (Xi'an, China) by real-time PCR.

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Bladder cancer ranks the second most common genitourinary tract cancer, and muscle-invasive bladder cancer (MIBC) accounts for approximately 25 % of all bladder cancer cases with high mortality. In the current study, with a total of 202 treatment-naïve primary MIBC patients identified from The Cancer Genome Atlas dataset, we comprehensively analyzed the genome-wide microRNA (miRNA) expression profiles in MIBC, with the aim to investigate the relationship of miRNA expression with the progression and prognosis of MIBC, and generate a miRNA signature of prognostic capabilities. In the progression-related miRNA profiles, a total of 47, 16, 3, and 84 miRNAs were selected for pathologic T, N, M, and histologic grade, respectively.

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  • - Chromophobe renal cell carcinoma (chRCC) is a prevalent kidney cancer subtype, and the study focused on 58 untreated chRCC patients to explore their genome-wide microRNA (miRNA) expression profiles.
  • - A total of 105 differentially expressed miRNAs were identified between tumor tissues and adjacent normal tissues, with an impressive 96.3% accuracy in distinguishing samples based on miRNA signatures.
  • - Specific miRNAs, particularly mir-191, mir-19a, mir-210, and mir-425, were linked to patient survival outcomes, with mir-210 identified as a significant independent factor for recurrence-free survival (RFS).
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  • Ischemic preconditioning (IPC) helps protect the kidneys from damage caused by ischemia-reperfusion injury (IRI), although the exact mechanisms are still not fully understood.* -
  • In a study with male Sprague-Dawley rats, different treatment groups were established to assess how IPC affects renal function, blood flow, and key nitric oxide synthase levels following vascular clamping.* -
  • Results showed that IPC significantly improved kidney function and blood flow, linked to increased levels of endothelial and inducible nitric oxide synthase (eNOS/iNOS) and nitric oxide (NO), though these benefits were negated when nitric oxide production was inhibited.*
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Papillary renal cell carcinoma (pRCC) is the second most prevalent subtype of kidney cancers. In the current study, we analyzed the global microRNA (miRNA) expression profiles in pRCC, with the aim to evaluate the relationship of miRNA expression with the progression and prognosis of pRCC.A total of 163 treatment-naïve primary pRCC patients were identified from the Cancer Genome Atlas dataset and included in this retrospective observational study.

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  • * Researchers analyzed miRNA expression profiles from tumor tissues and adjacent normal tissues in ccRCC patients, applying various statistical analyses to establish correlations with survival rates.
  • * A total of 147 differentially expressed miRNAs were identified, leading to the creation of a tumor-specific signature of 22 miRNAs, which was validated as an independent prognostic factor for ccRCC.
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  • Cr(VI) pollution poses significant environmental risks due to its harmful effects, including cancer risk and its ability to move through the environment.
  • Reducing Cr(VI) to the less toxic Cr(III) is an effective way to address this pollution, with bacteria being a key player in this bioremediation process due to their efficiency, eco-friendliness, and cost-effectiveness.
  • The review highlights various bacterial species that can reduce Cr(VI), explores the mechanisms and proteins involved in this reduction process, and outlines future research directions in the field.
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The phylogenetic analysis of dominant microbial populations in 8-year-old refuse samples was done in terms of the whole Bacterial and Archaeal domains. The results indicated that the Bacterial 16S rRNA genes sequences from the aged refuse were largely affiliated with the genus Bacillus, and that more than 60 % of the Archaeal sequences were closely related to the methanogenic archaeon. Some inferentially identified extremophilic organisms, particularly alkaliphiles and/or halophiles, were noted to be present in the aged refuse.

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The feasibility of electrolysis integrated with Fe(II)-activated persulfate (S2O8(2-)) oxidation to improve waste activated sludge (WAS) dewaterability was evaluated. The physicochemical properties (sludge volume (SV), total suspended solids (TSS) and volatile suspended solids (VSS)) and extracellular polymeric substances (EPS), including slime EPS, loosely bound EPS (LB-EPS) and tightly bound EPS (TB-EPS) were characterized to identify their exact roles in sludge dewatering. While dewaterability negatively corresponded to LB-EPS, TB-EPS, protein (PN) and polysaccharide (PS) in LB-EPS and TB-EPS, it was independent of SV, TSS, VSS, slime EPS and PN/PS.

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About 20 million tonnes of sludge (with 80% moisture content) is discharged by the sewage treatment plants per year in China, which, if not treated properly, can be a significant source of greenhouse gases (GHGs) emissions. Anaerobic digestion is a conventional sewage sludge treatment method and will continue to be one of the main technologies in the following years. This research has taken into consideration GHGs emissions from typical processes of sludge thickening+anaerobic digestion+dewatering+residue land application in China.

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Objective: To investigate the serum levels of sCD44v6 and sE-cadherin (sE-cad) in patients with esophageal squamous cell carcinoma.

Methods: The serum samples were collected from 65 cases of esophageal squamous cell carcinoma, 32 cases of erosive esophagitis and 35 healthy subjects. Serum sCD44v6 and sE-cad levels were measured by enzyme linked immunosorbent assay (ELISA).

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The diffusion mechanism of acetylene,which can inhibit the activity of methanogens, was studied. Paraffin wax and rosin were used as matrix of slow-release and calcium carbide was used as inhibition material. Based on the T.

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In this paper, it was comparatively studied about the adsorption or desorption behaviour for Cu2+ or Zn2+ ion onto different landfilled sludge. The results showed that Cu2+ or Zn2+ adsorption isotherm could significantly conform to Freundlich and Henry equations both for the directly landfilled sludge (SSA) and the solidifying landfilled sludge (SSB). Moreover, much higher adsorption capacities were found for Cu2+ on SSA but for Zn2+ on SSB, and the removal efficiency could reach 95% for Cu2+ by SSA with dosage being 10-20 g/L or Zn2+ by SSB with dosage being 5 g/L when the initial CU2+ or Zn2+ concentration was 128 mg/L.

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Enhancement of semi-aerobic landfill performance through a cowl installed on the gas ventilation pipeline using a simulated landfill box with 2 m x 1 m x 2 m in size was investigated, aiming at the maximum methane emission reduction. Influence of cowl on semi-aerobic environment formation was explored, and variety of methane and carbon dioxide concentrations at different wind speeds and mechanism of cowl operation were identified to provide information on design and improvement of semi-aerobic landfill. The results show that the cowl speeds up the semi-aerobic environment to shape, from over 50 days down to approximately 40 days, and reduces methane emission by promoting methane transformation to carbon dioxide.

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Magnesium oxychloride cement (MOC) was used for the stability agent in the stabilization experiments of sewage sludge. It is found that MgCl2 in MOC is a kind of water-absorbent, water absorption of MgCl2 can be achieved at 1.55 mL/g (per 100 g sludge).

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Objective: To study clinicopathologic features, treatment and prognosis of pilocytic astrocytoma (PA).

Methods: Histopathological, ultrastructural, immunohistochemical (EnVision method) and clinical features of 68 cases of PA were studied by microscopic investigation with correlation of clinical follow-up information when available.

Results: Thirty-five male patients and 33 female patients were studied.

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A series of batch tests were conducted to investigate the effects of initial pH on bio-hydrogen production from acid pretreated municipal sludge. The pH of sludge was first adjusted to 2.0, 3.

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Objective: To study the prognostic and clinical relevance of histologic subtyping of thymoma according to the World Health Organization (WHO) classification.

Methods: The clinicopathologic features of 108 patients with thymoma removed surgically were retrospectively reviewed. The histologic diagnosis of the tumors was made on the basis of 2004 WHO classification by two experienced pathologists.

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Objective: To investigate the histogenetic origin of primary central nervous system diffuse large B-cell lymphoma (DLBCL) with respect to the stage of B-cell differentiation, and identification of the relevant prognostic markers.

Methods: Immunohistochemical staining (EnVision method) for CD10, bcl-6, MUM-1, CD138 and FOXP1 antigens was performed on 47 paraffin-embedded sections.

Results: CD10, bcl-6, MUM-1 and FOXP1 expression in the tumor cells were 6.

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The individual effects and interactive effects of substrate concentration, ratio of inoculum to substrate, Ca(2+) concentration on the methane yield from the effluent of bio-hydrogen fermentation of food waste were investigated in this study. A central composite design (CCD) and response methodology (RSM) were employed in designing the experiments, in order to determine the optimum conditions for methane fermentation. The experiment results showed that the effects of substrate concentration, ratio of inoculum to substrate, Ca(2+) concentration were statistically significant at 5% level.

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Objective: To study the clinicopathological characteristics, immunohistochemical features and histogenesis of primary testicular carcinoid tumor and its differential diagnosis.

Methods: Light microscopy and immunohistochemical stains were performed in 4 cases of primary testicular carcinoid tumor.

Results: The patients sought care for scrotum mass presented from 2 to 36 years, 2 cases accompanied with tender swelling of the testis.

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