Radiofrequency ablation therapy for knee osteoarthritis: a systematic review and meta-analysis.

Objective: The objective of the study is to systematically analyze the safety and efficacy of radiofrequency ablation (RFA) therapy for the treatment of patients with knee osteoarthritis (KOA) and to assess the methodological quality of the published studies.

Methods: By searching the PubMed, Embase, and CENTRAL databases, we retrieved and collected relevant randomized controlled trials (RCTs) published up to June 26, 2023.

Results: We included 13 RCTs, involving a total of 865 patients.

Distal clavicle fractures treated by anteroinferior plating with a single screw: Two case reports.

Background: For the treatment of distal clavicle fractures, each treatment method has its own advantages and disadvantages, and there is no optimal surgical solution.

Case Summary: Based on this, we report 2 cases of distal clavicle fractures treated utilizing an anterior inferior plate with a single screw placed in the distal, in anticipation of providing a better surgical approach to distal clavicle fracture treatment. Two patients were admitted to the hospital after trauma with a diagnosis of distal clavicle fracture, and were admitted to the hospital for internal fixation of clavicle fracture by incision and reduction, with good postoperative functional recovery.

The influence of decreased salinity levels on the survival, growth and physiology of eelgrass Zostera marina.

Low salinity generally promotes the growth and propagation of temperate seagrasses, but the appropriate range is unclear. We subjected shoots of eelgrass Zostera marina to different salinity levels [10, 15, 20, 25, 30 PSU (control)] for 6 weeks under controlled laboratory conditions. We measured eelgrass responses in terms of survivorship, growth, productivity, leaf pigmentation and carbohydrate concentrations.

Physalin B reduces Aβ secretion through down-regulation of BACE1 expression by activating FoxO1 and inhibiting STAT3 phosphorylation.

Physalin B (PB), one of the major active steroidal constituents of Solanaceae Physalis plants, has a wide variety of biological activities. We found that PB significantly down-regulated β-amyloid (Aβ) secretion in N2a/APPsw cells. However, the underlying mechanisms are not well understood.