ZmHsp18 screened from the ZmHsp20 gene family confers thermotolerance in maize.

Heat stress has become one of the abiotic stresses that pose an increasing threat to maize production due to global warming. The Hsp20 gene family confers tolerance to various abiotic stresses in plants. However, very few Hsp20s have been identified in relation to maize thermotolerance.

Knockdown of ENO1 promotes autophagy dependent-ferroptosis and suppresses glycolysis in breast cancer cells via the regulation of CST1.

Autophagy-dependent ferroptosis and glycolysis play a significant role in tumor development. α-Enolase (ENO1), a glycolytic enzyme, has been demonstrated to function as a crucial modulator in breast cancer (BC). However, the specific mechanism by which ENO1 influences the ferroptosis and glycolysis of BC remains unclear.

Integrated metagenomics and metatranscriptomics analyses reveal the impacts of different Lactiplantibacillus plantarum strains on microbial communities and metabolic profiles in pickled bamboo shoots.

Effects of two different Lactobacillus plantarum fermentation processes on microbial communities and metabolic functions were evaluated using metagenomics and metatranscriptomics. Dominant species in Lactobacillus plantarum DACN4208 (LPIF8) and DACN4120 (LPIF10) were Lactobacillus pentosus and Lactobacillus plantarum, with Lactiplantibacillus comprised 75.31 % of the microbial community in LPIF10.

Strain-Induced Tunable Enhancement of Piezoelectricity in a Novel Molecular Multiferroic Material.

Multiferroics are appealing because of application potentials in data storage devices, sensors, transducers, and energy harvesters. Molecular multiferroics emerge as a promising alternative to inorganic multiferroics due to flexibility, light weight, low toxicity, solution processing, structural diversity, and chemical tunability. While researches have predominantly focused on perovskite structures, studies on molecular ionic multiferroics remain relatively limited.

Controlling strategies of methanol generation in fermented fruit wine: Pathways, advances, and applications.

Methanol is widely existed in fermented fruit wines (FFWs), and the concentration is excessive at times due to inappropriate fermentation conditions. Methanol is neurotoxic, and its metabolites of formaldehyde and formic acid can cause organic lesions and central respiratory system disorders. FFWs with unspecified methanol limits are often produced with reference to grape wine standards (250/400 mg/L).

Development and Validation of a Nomogram for Predicting Non-Adherence to Continuous Positive Airway Pressure Therapy in Patients with Obstructive Sleep Apnea.

Background: Continuous positive airway pressure (CPAP) is an effective treatment for obstructive sleep apnea (OSA), but its long-term efficacy is limited by poor patient adherence. This study aimed to develop and validate a predictive nomogram for CPAP non-adherence in patients with OSA.

Methods: This is a secondary analysis of a retrospective study.

and its compounds suppress hydrogen peroxide-induced oxidative stress in HT22 cells.

Unlabelled: This study aimed to explore the protective effects of (EA) leaves and its compounds on hydrogen peroxide (HO)-induced neuronal cell death. EA effectively reversed the HO-induced decrease in HT22 cell viability. Anti-apoptotic marker poly(ADP-ribose) polymerase significantly increased with EA treatment, whereas BAX/BCL2 and cleaved caspase-3/procaspase-3 ratios, which represent apoptotic markers, were dose-dependently decreased by EA treatment.

Genotoxicity of chlorinated hydrophobic organic compounds extracted from a source of drinking water.

As precursors of disinfection by-products (DBPs), sediment hydrophobic organic compounds (HPOCs) derived from six reservoirs along the Dongjiang River were chlorinated (Cl-WS) and then fractionated into two polar components (hydrophobic organic compounds (Cl-HOCs) and hydrophilic organic compounds (Cl-HICs)) by solid phase extraction. Based on Caco-2 cell exposure study, the genotoxicity of Cl-WS, Cl-HOCs and Cl-HICs was analyzed by reactive oxygen species (ROS) analysis, comet assay and ethoxyresorufin-O-deethylase assay. Protective effects of antioxidants (catalase, vitamin C and epigallocatechin 3-gallate (EGCG)) on genotoxicity of the chlorinated samples were investigated.

Organic-Inorganic Hybrid Perovskite for Ferroelectric Catalysis.

Organic-inorganic hybrid perovskite ferroelectric has gained significant attention for its structural flexibility and diversity. They can directly utilize metal nodes and organic groups as active sites in catalysis. Additionally, their ferroelectric polarization occurs around these active sites, significantly enhancing catalytic activity and demonstrating immense potential for applications.

Altered Functional Connectivity of Unimodal Sensory and Multisensory Integration Networks Is Related to Symptom Severity in Autism Spectrum Disorder.

Background: Atypical sensory processing is a prevalent feature of autism spectrum disorder (ASD) and constitutes a core diagnostic criterion in DSM-5. However, the neurocognitive underpinnings of atypical unimodal and multimodal sensory processing and their relationships with autism symptoms remain unclear.

Methods: In this study, we examined intrinsic functional connectivity (FC) patterns among 5 unimodal sensory and multisensory integration (MSI) networks in ASD using a large multisite dataset (N = 646) and investigated the relationships between altered FC, atypical sensory processing, social communicative deficits, and overall autism symptoms using correlation and mediation analyses.

APOA2 increases cholesterol efflux capacity to plasma HDL by displacing the C-terminus of resident APOA1.

The ability of high-density lipoprotein (HDL) to promote cellular cholesterol efflux is a more robust predictor of cardiovascular disease protection than HDL-cholesterol levels in plasma. Previously, we found that lipidated HDL containing both apolipoprotein A-I (APOA1) and A-II (APOA2) promotes cholesterol efflux via the ATP-binding cassette transporter (ABCA1). In the current study, we directly added purified, lipid-free APOA2 to human plasma and found a dose-dependent increase in whole plasma cholesterol efflux capacity.

Comprehensive evaluation of freezing tolerance in prickly ash and its correlation with ecological and geographical origin factors.

Low temperatures are a key factor affecting the growth, development, and geographical distribution of prickly ash. This study investigated the impact of ecological and geographical factors on the freezing tolerance of prickly ash germplasm. Thirty-seven germplasm samples from 18 different origins were collected, and their freezing tolerance was comprehensively evaluated.

Clinical analysis and identification of pediatric patients with colonic ulceration.

Background: A wide variety of diseases mimic inflammatory bowel disease (IBD). This study aimed to reduce the misdiagnosis among children with colonic ulcers.

Methods: Eighty-six pediatric patients with colonic ulcers detected by colonoscopy were enrolled in the retrospective study.

Stem cell activity-coupled suppression of endogenous retrovirus governs adult tissue regeneration.

Mammalian retrotransposons constitute 40% of the genome. During tissue regeneration, adult stem cells coordinately repress retrotransposons and activate lineage genes, but how this coordination is controlled is poorly understood. Here, we observed that dynamic expression of histone methyltransferase SETDB1 (a retrotransposon repressor) closely mirrors stem cell activities in murine skin.

Optimal control of Hydrocarbon Reducer (HC) injection based on Trust-Region-Reflective Algorithm (TRRA) and physical models for Diesel Oxidation Catalyst (DOC).

The aim of this paper is to control the DOC outlet gas temperature between 600 ± 15 °C by optimizing the hydrocarbon (HC) injection into the Diesel Oxidation Catalyst (DOC) for active regeneration of the downstream Diesel Particulate Filter (DPF). First, based on the physical model of the DOC thermal dynamics, the energy conservation equation for the gas phase temperature is simplified by using variable substitution, and the energy conservation equation for the solid phase temperature is simplified by considering only the heat generated by the HC injection. By solving the simplified model using the Trapezoidal Rule-Backward Differentiation Formula 2 (TR-BDF2) method and optimizing the model parameters in combination with the Gauss-Newton method, the computational efficiency and accuracy were significantly improved.

Establishment and characterization of a patient-derived metastatic extraskeletal Ewing sarcoma cell line ES-ZSS-1.

The methods available for treating metastatic Ewing sarcoma (ES) are inadequate; thus, innovative therapeutic approaches need to be developed. However, the lack of clinically relevant ES models has hindered the discovery of drugs for this disease. In this study, we established and characterized a patient-derived xenograft (PDX) cell line model, which was constructed using tumor tissue from a patient with metastatic extraskeletal ES.

Exploration of physical activity, sedentary behavior and insulin level among short sleepers.

Background: Sufficient physical activity and sleep duration are essential for overall health. While one-third of the US population reports short sleep (<7 h), which is proven to link with negative health status. Current evidence on the relationship between physical activity, sedentary behavior, and serum insulin level in short sleep groups is limited.

LCoRL Regulates Growth and Metabolism.

Genome-wide association studies (GWAS) in humans and livestock have identified genes associated with metabolic traits. However, the causality of many of these genes on metabolic homeostasis is largely unclear due to a lack of detailed functional analyses. Here we report ligand-dependent corepressor-like (LCoRL) as a metabolic regulator for body weight and glucose homeostasis.

Elevation and distraction of the Tibial periosteum in the management of chronic ischemic lower limb diseases.

Objective: This study investigates the effectiveness of tibia periosteum distraction (TPD) applied to the tibial periosteum, an innovative approach grounded in Ilizarov's tension-stress theory, for the treatment of ischemic diabetic foot and vasculitic foot conditions.

Methods: A retrospective analysis was conducted on 33 patients (36 limbs) who underwent TPD between June 2019 and May 2022. The study comprised 21 males (23 limbs) and 12 females (13 limbs), aged 41 to 80 years (mean age: 63.

V-Shaped Heterostructure Nanocavities Array with CM and EM Coupled Enhancement for Ultra-Sensitive SERS Substrate.

The field of semiconductor surface-enhanced Raman scattering (SERS) substrates has experienced significant advancements, leading to a wide range of applications in several fields. However, the quest for new ultra-sensitive semiconductor SERS materials is still of utmost importance. In this regard, an efficient and novel substrate, FTCNQ/MoS heterostructure is introduced, assisted by V-shaped aluminum anodic oxide (AAO) nanocavities with different depths.

Transcranial Alternating Current Stimulation: A Novel Neuromodulatory Treatment for Anxiety and Related Disorders.

Given the high prevalence and socioeconomic burden of anxiety disorders, there is an urgent need for effective, fast-acting, cost-efficient treatment alternatives to traditional psychotherapy. Transcranial alternating current stimulation (tACS), a noninvasive brain stimulation technique that modulates endogenous brain oscillations via the application of sinusoidal currents to the scalp, emerges as a promising neuromodulatory treatment. We reviewed oscillatory neuropsychopathology in anxiety, examined current evidence of tACS interventions for anxiety and related disorders, and proposed novel simulation targets and protocols.

Evaluation of a Low-Temperature Immersion Immunization Strategy for the Infectious Spleen and Kidney Necrosis Virus Gene-Deleted Attenuated Vaccine.

Background: Infectious spleen and kidney necrosis virus (ISKNV) poses a significant threat to aquaculture sustainability, particularly affecting mandarin fish () and causing significant economic losses.

Methods: To address this challenge, this study developed an ISKNV Δ vaccine strain, where the gene was knocked out. Infection assays conducted at 28 °C showed that the knocking out the gene decreased the virulence of ISKNV and reduced lethality against mandarin fish by 26.

The Inhibitory Effect of Essential Oil on the Dental Biofilm.

This study aimed to identify the inhibitory effect of essential oil (AREO) on the cariogenic properties of , which causes dental caries and dental plaque formation. After extracting the AREO, their effects on the growth and acid production of were examined. Furthermore, biofilm formation was observed on the resin teeth surface.