Investigating grouting body nonuniform expansion in anisotropic underground soil mechanics.

An improved method tailored for anisotropic soft soils is presented, integrating theoretical models and field data to calculate the grouting quantity required for tunnel foundations. Given the complexities of soil interactions, particularly under variable geological conditions, this approach incorporates nonlinear behaviors and empirical field data to improve accuracy. Our findings reveal that integrating these theoretical frameworks significantly enhances the understanding of stress-strain behavior during grouting, enabling precise calculations of both axial and vertical expansion.

Elevated urinary levels of primary aromatic amines in residents from e-waste dismantling area: Associations with oxidative stress and kidney injury.

Currently, the adverse effects of carcinogenic primary aromatic amines (PAAs) released from electronic waste (e-waste) dismantling activities on human health remain unclear. Therefore, this study examined the urinary concentrations of 28 PAAs in residents living in both e-waste dismantling and control areas, and the median concentrations (unit: μg/g Cre) of aniline (ANI) (1.06 vs.

Magnetic field dependence of - defects in hexagonal boron nitride.

The interface with spin defects in hexagonal boron nitride has recently become a promising platform and has shown great potential in a wide range of quantum technologies. Varieties of spin properties of - defects in hexagonal boron nitride (hBN) have been researched widely and deeply, like their structure and coherent control. However, little is known about the influence of off-axis magnetic fields on the coherence properties of - defects in hBN.

Generation of the broadband indistinguishable two-photon state in the telecom band.

The indistinguishable photon-pair sources are valuable in many quantum information applications, such as quantum microscopy, quantum synchronization, and quantum metrology. Based on cascaded sum-frequency generation (SFG) and spontaneous parametric downconversion (SPDC) processes, we propose and demonstrate a scheme for the generation of spatially separated broadband indistinguishable photon pairs in the telecom band by using only one piece of a fiber-pigtailed periodically poled lithium niobate waveguide in a modified Sagnac loop. The measured joint spectral intensity of the generated entangled photon pairs is 7.

Predicting Futile Recanalization by Cerebral Collateral Recycle Status in Patients with Endovascular Stroke Treatment: The CHANOA Score.

Rationale And Objectives: The correlation between collateral circulation and futile recanalization (FR) is still controversial, and few studies have explored the influence of comprehensive cerebral collateral circulation on FR after endovascular stroke treatment. Therefore, based on cerebral collateral recycle (CCR) status, we aimed to establish an effective scoring system to identify the probability of FR.

Methods: This was a multicenter retrospective cohort study.

Robust phosphine-based covalent-organic framework palladium catalysts for the highly efficient carbonylation coupling reaction.

The first vinyl-linked PPh-based covalent-organic frameworks (Pd@TMBen-PPh and Pd@TMBen-4F-PPh) were facilely constructed direct three-component Knoevenagel condensation, which could serve as outstanding heterogeneous catalysts for the Pd-catalyzed carbonylation coupling reaction owing to the synergistic effect of the flexible PPh-ligated Pd complexes and the rigid framework.

Construction of a MoO/MoS Heterojunction via the Surface Sulfurization of the Oxide and Its Photocurrent-Switching Characteristics in the Range of the Broadband Light Spectrum.

In order to utilize the longer wavelength light, the surface sulfurization of MoO was carried out. The photocurrent responses to typical 650, 808, 980, and 1064 nm light sources with Au gap electrodes were investigated. The results showed that the surface S-O exchange of MoO improved the interfacial charge transfer in the range of the broadband light spectrum.

PPARA variant rs1800234 had a dose dependent pharmacogenetics impact on the therapeutic response to chiglitazar.

Background: Our objective was to explore the pharmacogenetic impact of three known functional variants in drug target genes and determine whether they can explain the inter-individual variation in therapeutic response.

Methods: In a post hoc analysis of data from randomized controlled clinical trials of chiglitazar, we genotyped 481 Chinese patients with T2DM and investigated the association of variants in PPAR genes with the therapeutic outcome separated by dose using linear regression.

Results: rs1800234, a gain-of-function variant of PPARA, had a dose-dependent pharmacogenetic impact on the therapeutic response to chiglitazar.

Observation of THz surface waves escaping from metal gratings through a dielectric substrate.

Extensive research has been conducted on generating THz waves using Smith-Purcell radiation, yet a portion of the electron bunch's interaction energy with the gratings is confined to the metal gratings' surface, leading to a low THz radiation power. This paper experimentally demonstrates that metal gratings with a dielectric substrate can emit the resonant modes in surface waves when excited by relativistic femtosecond electron bunches. The observed spectra of the resonant THz waves align well with the theoretical estimations derived from the configuration's dispersion relation and 3D simulations.

Trio-whole exome sequencing reveals the importance of de novo variants in children with intellectual disability and developmental delay.

Understanding the genetic basis of developmental delay (DD) and intellectual disability (ID) remains a considerable clinical challenge. This study evaluated the clinical application of trio whole exome sequencing (WES) in children diagnosed with DD/ID. The study comprised 173 children with unexplained DD/ID.

Isolation and characterization of spike S2-specific monoclonal antibodies with reactivity to pan-coronaviruses.

• Five broad-spectrum mAbs identified from COVID-19 convalescents and vaccinees possessed the ability to recognize spike S2 of pan-coronaviruses. • Five mAbs targeted distinct but conserved epitopes on spike S2 of pan-coronaviruses. • Three of these five mAbs were competitively bound to the fusion peptide epitopes of coronavirus spike protein.

Regio- and Enantioselective Nickel-Catalyzed Ipso- and Remote Hydroamination Utilizing Organic Azides as Amino Sources for the Synthesis of Primary Amines.

Primary amines serve as key synthetic precursors to most other -containing compounds, which are important in organic and medicinal chemistry. Herein, we present a NiH-catalyzed mild ipso- and remote hydroamination technique that utilizes organic azides as deprotectable primary amine sources. This strategy offers a highly flexible platform for the efficient construction of α-chiral branched primary amines, as well as linear primary amines.

Broad cross neutralizing antibodies against sarbecoviruses generated by SARS-CoV-2 infection and vaccination in humans.

The outbreaks of severe acute respiratory syndrome coronavirus (SARS-CoV-1), Middle East respiratory syndrome coronavirus (MERS-CoV), and SARS-CoV-2 highlight the need for countermeasures to prevent future coronavirus pandemics. Given the unpredictable nature of spillover events, preparing antibodies with broad coronavirus-neutralizing activity is an ideal proactive strategy. Here, we investigated whether SARS-CoV-2 infection and vaccination could provide cross-neutralizing antibodies (nAbs) against zoonotic sarbecoviruses.

Targeted sonogenetic modulation of GABAergic interneurons in the hippocampal CA1 region in status epilepticus.

Sonogenetics is an advanced ultrasound-based neurostimulation approach for targeting neurons in specific brain regions. However, the role of sonogenetics in treating status epilepticus (SE) remains unclear. Here, we aimed to investigate the effects of ultrasound neurostimulation and MscL-G22S (a mechanosensitive ion channel that mediates Ca influx)-mediated sonogenetics (MG-SOG) in a mouse model of kainic acid (KA)-induced SE.

Molecular investigation of bamboo during stress relaxation using custom-built mechanical loading platform coupled with Raman spectroscopy.

Bamboo holds significant potential as a substitute for plastics. Stress relaxation is a critical property during the fixation stage of plastic formation for bamboo products intended to replace plastic. However, research on this topic has been limited.