Exosomes derived from umbilical cord mesenchymal stem cells promote healing of complex perianal fistulas in rats.

Background: Complex perianal fistulas, challenging to treat and prone to recurrence, often require surgical intervention that may cause fecal incontinence and lower quality of life due to large surgical wounds and potential sphincter damage. Human umbilical cord-derived MSCs (hUC-MSCs) and their exosomes (hUCMSCs-Exo) may promote wound healing.

Methods: This study assessed the efficacy, mechanisms, and safety of these exosomes in treating complex perianal fistulas in SD rats.

Plasma proteomics identify biomarkers and undulating changes of brain aging.

Proteomics enables the characterization of brain aging biomarkers and discernment of changes during brain aging. We leveraged multimodal brain imaging data from 10,949 healthy adults to estimate brain age gap (BAG), an indicator of brain aging. Proteome-wide association analysis across 4,696 participants of 2,922 proteins identified 13 significantly associated with BAG, implicating stress, regeneration and inflammation.

The era of digital trade: Exploring new mechanisms and threshold effects for green upgrading of manufacturing companies.

The green transformation of manufacturing companies is of strategic importance for promoting sustainable development, optimising energy structure and improving environmental quality. This article empirically examines the impact of digital trade on the green transformation of manufacturing companies and the role of green technology innovation using panel data of Chinese A-share listed manufacturing companies from 2011 to 2021. The findings are as follows: digital trade significantly accelerates the green transformation of manufacturing companies, and this effect is more obvious in mature companies, highly competitive industries and non-renewable energy companies.

Atlas of the plasma proteome in health and disease in 53,026 adults.

Large-scale proteomics studies can refine our understanding of health and disease and enable precision medicine. Here, we provide a detailed atlas of 2,920 plasma proteins linking to diseases (406 prevalent and 660 incident) and 986 health-related traits in 53,026 individuals (median follow-up: 14.8 years) from the UK Biobank, representing the most comprehensive proteome profiles to date.

Large-scale proteomic analyses of incident Alzheimer's disease reveal new pathophysiological insights and potential therapeutic targets.

Pathophysiological evolutions in early-stage Alzheimer's disease (AD) are not well understood. We used data of 2923 Olink plasma proteins from 51,296 non-demented middle-aged adults. During a follow-up of 15 years, 689 incident AD cases occurred.

Heavy metal stabilization via copyrolysis of comodified vermiculite with municipal sludge/aged refuse: Comprehensive analysis of hazards and characteristics of multiple coexisting heavy metals.

Mg impregnation, intercalation-exfoliation, and thermal activation methods were employed to create various types of modified vermiculite (MV), with their combination creating linked-modified vermiculite (LMV). Copyrolysis of MV with municipal sludge (MS)/aged refuse (AF) in a fluidized bed improved heavy metal (HM) stability compared to copyrolysis of original vermiculite, with LMV demonstrating superior performance compared to other types of MV. The HM retention rate, potential ecological risk assessment, and form distribution analysis supported the efficacy of the approach.

Plasma proteomics identifies proteins and pathways associated with incident depression in 46,165 adults.

Proteomic alterations preceding the onset of depression offer valuable insights into its development and potential interventions. Leveraging data from 46,165 UK Biobank participants and 2920 plasma proteins profiled at baseline, we conducted a longitudinal analysis with a median follow-up of 14.5 years to explore the relationship between plasma proteins and incident depression.

Metal ion levels after metal-on-metal hip resurfacing: A single-center longitudinal study of Chinese patients.

This study aimed to investigate the long-term serum metal ion levels of patients who received metal-on-metal hip resurfacing arthroplasty (MoM HRA). We conducted a retrospective study of 99 patients (110 hips) from March 2006 to May 2017 who underwent MoM HRA. The Harris Hip Score (HHS) and the University of California at Los Angeles (UCLA) activity score were measured, and the patients underwent clinical and radiological management.

The m6A writer KIAA1429 regulates photoaging progression via MFAP4-dependent collagen synthesis.

Background: N6-Methyladenosine (mA) methylation, a common form of RNA modification, play an important role in the pathogenesis of various diseases and in the ontogeny of organisms. Nevertheless, the precise function of mA methylation in photoaging remains unknown.

Objectives: This study aims to investigate the biological role and underlying mechanism of mA methylation in photoaging.

Quercetin inhibited LPS-induced cytokine storm by interacting with the AKT1-FoxO1 and Keap1-Nrf2 signaling pathway in macrophages.

Cytokine storm (CS) emerges as an exacerbated inflammatory response triggered by various factors such as pathogens and excessive immunotherapy, posing a significant threat to life if left unchecked. Quercetin, a monomer found in traditional Chinese medicine, exhibits notable anti-inflammatory and antiviral properties. This study endeavors to explore whether quercetin intervention could mitigate CS through a combination of network pharmacology analysis and experimental validation.

THE DELIVERY OF PD-L1 SIRNA BY NEUTROPHIL-TARGETED LIPID NANOPARTICLES EFFECTIVELY AMELIORATES SEPSIS.

Background: Sepsis, a complex and life-threatening disease, poses a significant global burden affecting over 48 million individuals. Recently, it has been reported that programmed death-ligand 1 (PD-L1) expressed on neutrophils is involved in both inflammatory organ dysfunction and immunoparalysis in sepsis. However, there is a dearth of strategies to specifically target PD-L1 in neutrophils in vivo .

Contrastive machine learning reveals Parkinson's disease specific features associated with disease severity and progression.

Parkinson's disease (PD) exhibits heterogeneity in terms of symptoms and prognosis, likely due to diverse neuroanatomical alterations. This study employs a contrastive deep learning approach to analyze Magnetic Resonance Imaging (MRI) data from 932 PD patients and 366 controls, aiming to disentangle PD-specific neuroanatomical alterations. The results reveal that these neuroanatomical alterations in PD are correlated with individual differences in dopamine transporter binding deficit, neurodegeneration biomarkers, and clinical severity and progression.

Linking fatty liver diseases to hepatocellular carcinoma by hepatic stellate cells.

Hepatic stellate cells (HSCs), a distinct category of non-parenchymal cells in the liver, are critical for liver homeostasis. In healthy livers, HSCs remain non-proliferative and quiescent. However, under conditions of acute or chronic liver damage, HSCs are activated and participate in the progression and regulation of liver diseases such as liver fibrosis, cirrhosis, and liver cancer.

UBE2D1 promotes glioblastoma proliferation by modulating p21 ubiquitination.

Glioblastoma (GBM) cells exhibit aberrant proliferative abilities and resistance to conventional therapies. However, the mechanisms underlying these malignant phenotypes are poorly understood. In this study, we identified ubiquitin-conjugating enzyme E2D1 (UBE2D1) as a crucial stimulator of GBM development.

Prediction of Future Parkinson Disease Using Plasma Proteins Combined With Clinical-Demographic Measures.

Background And Objectives: Identification of individuals at high risk of developing Parkinson disease (PD) several years before diagnosis is crucial for developing treatments to prevent or delay neurodegeneration. This study aimed to develop predictive models for PD risk that combine plasma proteins and easily accessible clinical-demographic variables.

Methods: Using data from the UK Biobank (UKB), which recruited participants across the United Kingdom, we conducted a longitudinal study to identify predictors for incident PD.

Shift work effects on incident neuropsychiatric disorders and shift work tolerance.

Background: Shift work is associated with susceptibility to several neuropsychiatric disorders. This study aims to investigate the effect of shift work on the incidence of neuropsychiatric disorders, and highlighting how individual variability may influence the association.

Methods: UK Biobank participants with employment information were included.