Klebsiella pneumoniae, a human-dog shuttle organism for the genes of CTX-M ESBL.

Antimicrobials reserved for human medicines are permitted for companion animals and it is important to understand multidrug-resistant pathogens recovered from companion animals in terms of epidemiological correlation with human pathogens and possibility of transmission to human-beings. Seventeen of each CTX-M-type extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-EC) and Klebsiella pneumoniae (ESBL-KP) canine isolates were assessed. Entire genomes of the 34 isolates were sequenced.

Amplification of the Chromosomal Gene in Escherichia coli Expanding the Spectrum of Resistance under Antimicrobial Pressure.

Various forms of adaptive evolution occur in clinical isolates in response to the presence of antimicrobial drugs. Among a total of 171 CTX-M-9 group/family extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli blood isolates recovered between 2016 and 2017 in six general hospitals, 50.3% of the isolates possessed the gene in their chromosome rather than in a plasmid.

Trajectory of genetic alterations associated with colistin resistance in Acinetobacter baumannii during an in-hospital outbreak of infection.

Background: As carbapenem-resistant Acinetobacter baumannii is dominant in clinical settings, the old polymyxin antibiotic colistin has been revived as a therapeutic option. The development of colistin resistance during treatment is becoming a growing concern.

Objectives: To access low- to mid-level colistin-resistant A.

A Novel KPC Variant KPC-55 in ST307 of Reinforced Meropenem-Hydrolyzing Activity.

A novel carbapenemase (KPC) variant, KPC-55, produced by a ST307 strain was characterized. strain BS407 was recovered from an active surveillance rectal swab of a patient newly admitted to a general hospital in Busan, South Korea. Carbapenemase production was confirmed by the modified Hodge test, and the MICs of β-lactams were determined by the broth microdilution method.

Sulforaphane-PLGA microspheres for the intra-articular treatment of osteoarthritis.

Sulforaphane (SFN) is a member of the isothiocyanate family that has anti-inflammatory action as well as anti-carcinogenic properties. The authors have devised an intra-articular injectable SFN-PLGA microsphere system that can be used for treating osteoarthritis (OA). The purpose of this study was to evaluate the in vitro and in vivo efficacy of the SFN-PLGA microsphere system.

Epigenetics in osteoarthritis and its implication for future therapeutics.

Introduction: Changes occurring in the chondrocyte gene that control articular cartilage are important for the onset and progression of osteoarthritis (OA). However, actual development of the disease may be also controlled by changes in epigenome.

Areas Covered: Topics include the association of the three components of epigenetic modification, i.