Publications by authors named "You C Kim"

Article Synopsis
  • Actinic keratoses (AKs) are UV-induced skin patches that raise the likelihood of developing non-melanoma skin cancer (NMSC) and this study focuses on their incidence and risk in Korea.
  • A large cohort study involving nearly 3,000 AK patients showed an NMSC risk that is significantly higher (adjusted hazard ratio of 8.91) in those with AK compared to controls, especially among women, individuals under 60, and lower-income patients.
  • Over a 16-year period, the cumulative incidence of NMSC was 4.19% in AK patients, underscoring the importance of enhanced monitoring and treatment for this group in Korea.
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Purpose: Early intervention of surgical scars with a pulsed dye laser is known to effectively prevent pathologic scars. Despite multiple reports on the effectiveness of the treatment, very few studies have demonstrated its appropriate initiation timing. In this study, our objective was to determine the optimal timing for initiating laser treatment following thyroidectomy.

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  • Acral lentiginous melanoma (ALM) is mainly found in Asians and is a rare but aggressive subtype of melanoma, prompting research into distinguishing it from benign acral nevi (ABN) using immunohistochemical (IHC) markers.
  • In a study involving 53 ALM and 19 ABN specimens, key IHC markers like PRAME and Ki-67 showed significantly higher expression in ALM, while p16 levels were lower in ALM, highlighting potential markers for diagnosis.
  • The findings suggest that PRAME is the most promising marker for identifying ALM, although additional large-scale studies are necessary to confirm these results.
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Background: Pigmented contact dermatitis (PCD), a rare variant of non-eczematous contact dermatitis, is clinically characterized by sudden-onset brown or grey pigmentation on the face and neck. It is hypothesized to be caused by repeated contact with low levels of allergens.

Objectives: This study evaluated the risk of using hair dyes in patients with PCD in Korea.

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Introduction: Lichen sclerosus et atrophicus (LS) is rare skin condition characterized by the presence of whitish patches primarily affecting the genital and perianal areas, though it can occur other parts of the body. LS may result in skin depigmentation without textural changes and should be differentiated from vitiligo. However, the histopathological features of hypopigmentation during vitiligo and LS have rarely been compared and have not been precisely described using quantitative immunohistochemical analysis.

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Solar lentigo (SL) commonly occurs as hyperpigmented macules in areas exposed to ultraviolet radiation. It typically shows an increased number of melanocytes in the basal cell layer of the skin, with or without elongated rete ridges. This retrospective study aimed to evaluate the characteristic dermoscopic patterns, reflecting different histopathological features, which might be valuable in predicting the possibility of postinflammatory hyperpigmentation (PIH) occurring after laser treatment.

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  • Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer that has mostly been studied in Caucasians, leaving a knowledge gap about its characteristics and prognosis in Asian populations, particularly in South Korea.
  • This research, a nationwide study conducted across 12 centers, evaluated 161 patients with MCC, revealing a higher incidence in females and highlighting that the disease stage at diagnosis significantly influences overall survival rates.
  • The findings indicate that MCC exhibits unique clinicopathological features in South Korea, emphasizing the importance of understanding geographical variations in cancer epidemiology.
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Leishmaniasis is a neglected tropical disease and an infectious disease transmitted by sandflies that occurs worldwide. In the absence of physicians seeking to identify the causes of disease in non-endemic areas, appropriate diagnoses cannot be made, thereby hampering effective treatment. In this report, we examined a nodular lesion on a patient's chin by performing a biopsy and molecular analysis.

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Alopecia areata (AA) is an autoimmune cutaneous disorder reported to be related to various immunologic diseases and psychiatric disorders. Some AA patients report the onset of patchy hair loss after surgeries under general anesthesia (GA). However, no large-scale studies have been conducted on the relationship between AA and GA.

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Background: Among various treatment modalities of actinic keratosis (AK), ablative fractional laser-assisted photodynamic therapy (fractional PDT) has shown higher efficacy despite shorter incubation time. However, there are lack of real-world studies on the therapeutic response of ablative PDT for AK and the factors that can predict the therapeutic response.

Purpose: The aim of this study was to analyze the association between clinical characteristics and treatment outcomes of fractional PDT.

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Background: Data illustrating the impact of atopic dermatitis (AD) on lives of adults with AD in South Korea are limited.

Objective: To assess the AD disease severity and its impact on quality of life (QoL) in patients with AD from South Korea.

Methods: Patients with AD utilizing the specialist dermatology services of major hospitals in South Korea were assessed for disease severity using Eczema Area and Severity Index (EASI) score, for QoL using Dermatology Life Quality Index (DLQI) (for QoL), and for comorbidities and treatment experience via retrospective review of 12-month medical records.

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This randomized, double-blind, and sham device-controlled trial aimed to evaluate the efficacy and safety of home-based photobiomodulation therapy using an 830-nm light-emitting diode (LED)-based device for the prevention of and pain relief from thyroidectomy scars. Participants were randomized to receive photobiomodulation therapy using an LED device or a sham device without an LED from 1 week postoperatively for 4 weeks. Scars were assessed using satisfaction scores, the numeric rating scale (NRS) score for pain, Global Assessment Scale (GAS), and Vancouver Scar Scale (VSS) scores.

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Objectives: The pulsed dye laser (PDL) is an effective modality for preventing and improving hypertrophic scars (HSs). However, the heterogeneity of the parameter settings of the laser and subjective scar assessment methods used in most studies resulting in uncertainty with treatment plans. Therefore, we investigated the treatment effect of the PDL (V-beam; Candela Laser Corporation) on HSs in post-thyroidectomy patients using three-dimensional imaging analysis and intended to provide a systemic and optimal treatment protocol.

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Article Synopsis
  • Psoriasis is heavily influenced by the IL-23/IL-17 cytokine axis, with IL-23 typically produced by immune cells, but this study also focused on its production by keratinocytes (skin cells).
  • Using single-cell RNA sequencing data, researchers found that keratinocytes and dendritic cells both express IL23A, indicating that keratinocytes may play a role in psoriasis.
  • In a mouse model of psoriasis, they discovered that keratinocyte-derived IL-23 is linked to IL-36 levels, and blocking IL-23 signaling decreased IL-36 expression, highlighting a potential new pathway in psoriasis progression.
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Acral lentiginous melanoma (ALM) is the most common subtype of cutaneous melanoma among Asians; punch biopsy is widely performed for its diagnosis. However, the pathologic parameters evaluated via punch biopsy may not be sufficient for predicting disease prognosis compared to the parameters evaluated via excisional biopsy. We investigated whether changes in Breslow thickness (BT) between initial punch biopsy results and final pathology reports can affect the prognosis of ALM.

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Background: Low-level laser (light) therapy is a promising technology that stimulates healing, relieves pain and inflammation, and restores function in injured body parts. However, few studies have compared the effects of light-emitting diodes of different fluence levels or different treatment durations.

Objective: Here, we investigated the effects of various fluence levels and treatment durations on wound closure in mice.

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