Publications by authors named "Yotsukura M"
Background: In malignant pleural mesothelioma), it is difficult to evaluate the degree of tumor progression using imaging findings. It is essential to develop an objective index that is independent of imaging findings and useful for assessing the degree of tumor progression and indications for surgery.
Methods: We retrospectively evaluated the data of 79 patients with malignant pleural mesothelioma who underwent extrapleural pneumonectomy or pleurectomy/decortication at our institution between 1999 and 2022.
Article Synopsis
- The JCOG0802/WJOG4607L trial showed segmentectomy is better than lobectomy for overall survival in small-peripheral non-small-cell lung cancer, but locoregional relapse (LR) is still a concern.
- An analysis of 1105 patients with various tumor sites determined that factors like solid tumor appearance and close margins significantly increased the risk of LR after segmentectomy.
- Key findings stress the importance of using thin-section CT scans and ensuring sufficient margin distance to minimize the risk of LR in patients undergoing segmentectomy.
The perioperative treatments for non-small cell lung cancer (NSCLC) should control both local and microscopic systemic disease, because the survival of patients with NSCLC who underwent surgical resection alone has been dismal except in stage IA patients. One way to improve surgical outcome is the administration of chemotherapy before or after the surgical procedure. During the last two decades, many clinical studies have focused on developing optimal adjuvant or neoadjuvant cisplatin-based chemotherapy regimens that can be combined with surgical treatment and/or radiotherapy.
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- The Lung Cancer Surgical Study Group (LCSSG) of the Japan Clinical Oncology Group (JCOG), formed in 1986, has expanded from 26 to 52 institutions, involving various specialists in lung cancer treatment.
- Initially focused on combined therapies, the group has shifted to studying surgical options for small-sized and peripheral non-small cell lung cancer since the 2000s, demonstrating the effectiveness of sublobar resection through clinical trials.
- With advances in targeted therapies and the need for personalized medicine, the JCOG-LCSSG is adapting treatment strategies and conducting numerous clinical trials to enhance comprehensive care for lung cancer patients.
Background: Both small-cell carcinoma (SCLC) and large-cell neuroendocrine carcinoma (LCNEC) of the lung are often clinically dealt with as being in the same category as neuroendocrine carcinoma, and their clinical differences have not been adequately assessed.
Methods: The postoperative prognosis was retrospectively analyzed using the data of 196 patients who underwent resection for SCLC or LCNEC.
Results: Of the patients included, 99 (50.
Objective: Oncological feasibility of segmentectomy for internal non-small cell lung cancer (NSCLC) has not been assessed adequately. We assessed the oncological feasibility of segmentectomy for inner-located NSCLC by investigating surgical margins and patient prognosis after undergoing the procedure.
Methods: Of the 3555 patients who underwent resection for lung cancer between 2013 and 2019 at our institution, 659 patients who underwent segmentectomy for clinical stage 0 to stage1A NSCLC were included in this study.
Introduction: Spread through air spaces (STAS) consists of lung cancer tumor cells that are identified beyond the edge of the main tumor in the surrounding alveolar parenchyma. It has been reported by meta-analyses to be an independent prognostic factor in the major histologic types of lung cancer, but its role in lung cancer staging is not established.
Methods: To assess the clinical importance of STAS in lung cancer staging, we evaluated 4061 surgically resected pathologic stage I R0 NSCLC collected from around the world in the International Association for the Study of Lung Cancer database.
Article Synopsis
- The study investigates the early stages of tumor development, specifically focusing on lung adenocarcinomas like adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma.
- Researchers conducted comprehensive genomic analysis on 76 lung cancer samples, combining sequencing data with transcriptomic and epigenomic information.
- Findings indicate that very early-stage tumors have minimal somatic mutations, primarily in key driver mutations, leading to copy number changes and global DNA hypomethylation as the disease progresses, particularly in Noguchi type B tumors.
Introduction: An international database was created by the International Association for the Study of Lung Cancer to inform on the ninth edition of the TNM classification of lung cancer. The present analyses concern its T component.
Methods: Data on 124,581 patients diagnosed with lung cancer from January 1, 2011 to December 31, 2019 were submitted to the International Association for the Study of Lung Cancer database.
Article Synopsis
- - Salivary gland-type tumors (SGTs) of the lung, which are rare and have a generally good prognosis, primarily include mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC), constituting over 90% of cases.
- - Symptoms of bronchial obstruction like wheezing and shortness of breath typically lead to early diagnosis, with a reported 5-year survival rate of 63.4%.
- - Treatment commonly involves surgical methods such as lobectomy or pneumonectomy, with lymphadenectomy recommended for patients with MEC, while advanced cases necessitate tailored therapies based on the tumor subtype.
Background: Preoperative fluorine-18-fluorodeoxyglucose positron emission tomography (F-FDG PET) of thymic epithelial tumors (TETs) is well known for identifying malignant-grade TETs; however, its predictive power for determining locally advanced tumors, lymph node (LN) metastasis, and prognosis remains unknown.
Patients And Methods: We retrospectively evaluated patients with resectable TETs who were preoperatively assessed using F-FDG PET from January 2012 to January 2023. The receiver operating characteristic curve was used to evaluate the cutoff value of the maximum standardized uptake value (SUVmax) to predict advanced-stage disease.
Article Synopsis
- - The study investigates the role of Delta-like ligand 3 (DLL3) as a therapeutic target in small-cell lung cancer (SCLC) and its impact on the tumor microenvironment (TME) and patient outcomes.
- - Results show that in limited-stage SCLC, DLL3 expression is associated with more neoantigens but reduced immune activity, leading to lower levels of immune cells like T cells and dendritic cells.
- - In extensive-stage SCLC, patients with DLL3-expressing tumors experience significantly worse progression-free survival when treated with standard chemotherapy and anti-PD-L1 therapy, indicating resistance linked to suppressed immune responses.
Background And Objectives: This study examined the trend of hazards for postoperative recurrence of lung cancer according to pathologic stages.
Methods: We reviewed the records of 1987 patients who underwent resection for lung cancer between 2007 and 2012. Postoperative recurrence and development of second primary lung cancer were analyzed to evaluate the trend of hazard rate.
Objective: Segmentectomy as a parenchymal-sparing surgical approach has been recommended over lobectomy in select patients with early-stage non-small cell lung cancer. This study aimed to address 3 aspects of segmentectomy ("patient indication"; "segmentectomy approaches"; "lymph node assessment") where there is limited clinical guidance.
Methods: A modified Delphi approach comprising 3 anonymous surveys and 2 expert discussions was used to establish consensus on the aforementioned topics among 15 thoracic surgeons (2 Steering Committee; 2 Task Force; 11 Voting Experts) from Asia who have extensive segmentectomy experience.
Background: The use of endobronchial Watanabe spigots for intractable secondary pneumothorax in patients with cancer has not been adequate. This study aimed to investigate the use of endobronchial Watanabe spigots for intractable pneumothorax in patients with malignant tumors.
Methods: Consecutive patients with malignant tumors who underwent occlusion with an endobronchial Watanabe spigot for intractable pneumothorax associated with perioperative treatment or drug therapy at our institution between January 2014 and February 2022 were reviewed.
Objectives: We evaluated the potential of preoperative fluorine-18-fluorodeoxyglucose positron emission tomography to predict invasive thymic epithelial tumours in patients with computed tomography-defined clinical stage I thymic epithelial tumours ≤5 cm in size who are generally considered to be candidates for minimally invasive approaches.
Methods: From January 2012 to July 2022, we retrospectively analysed patients who exhibited tumour-node-metastasis (TNM) clinical stage I thymic epithelial tumours with lesion sizes ≤5 cm as determined by computed tomography. All patients underwent fluorine-18-fluorodeoxyglucose positron emission tomography preoperatively.
Article Synopsis
- - The study focuses on the effectiveness of platinum etoposide and anti-PD-L1 therapy (ACE) for treating extensive-stage small cell lung cancer (ES-SCLC) and investigates how patient characteristics, particularly tumor-infiltrating lymphocyte (TIL) levels and SCLC subtypes, affect treatment outcomes.
- - Researchers classified limited-stage small cell lung cancer (LS-SCLC) patients into four subtypes based on genetic data, finding that the SCLC-I subtype had the highest immune response and density of CD8-positive TILs.
- - Results showed that while ACE therapy efficacy did not vary significantly among pathological subtypes in the ES-SCLC group, patients with higher TIL counts had longer progression-free survival,
Article Synopsis
- Ciliated muconodular papillary tumor/bronchiolar adenoma (CMPT/BA) is a new type of benign lung tumor whose relationship with specific lung cancers remains uncertain.
- A study examined 8 cases of primary lung cancer coexisting with CMPT/BA, finding that most patients were older male smokers, with various types of lung cancer present.
- Genetic analysis revealed distinct mutation profiles for CMPT/BA and lung cancer, indicating that they likely develop independently from one another.
Objectives: With recent improvements in surgical techniques for segmentectomy, we hypothesized that segmentectomy is feasible and more effective than wedge resection for non-small-cell lung cancer (NSCLC). We compared perioperative and oncological outcomes for segmentectomy and wedge resection.
Methods: We performed a retrospective analysis of 720 patients who underwent sublobar resection (segmentectomy, 479; wedge resection, 241) for clinical stage 0 or I NSCLC from January 2017 to June 2020.
Objective: We aimed to visualize complicated patterns of lymph node metastases in surgically resected non-small cell lung cancer by applying a data mining technique.
Methods: In this retrospective study, 783 patients underwent lobectomy or pneumonectomy with systematic mediastinal lymph node dissection for non-small cell lung cancer between January 2010 and December 2018. Surgically resected lymph nodes were classified according to the International Association for the Study of Lung Cancer lymph node map.
Background: The 8th edition of the TNM stage classification of lung cancer was developed based on an evaluation of the 5-year prognosis using an international database. Since recurrence after 5 years postoperatively is known to develop, the applicability of the stage classification beyond 5 years after treatment needs to be evaluated.
Patients And Methods: Postoperative prognosis and prognostic indicators were analyzed using data for 648 patients of pathological stage IA adenocarcinoma, who underwent complete resection between 2007 and 2012.
Introduction: This study explored the predictors of a histological aggressive component in ground glass opacity-containing lung adenocarcinoma.
Methods: Of the 2388 patients who underwent resection for lung cancer at our institute between 2017 and 2020, we collected data on the 501 patients with ground glass opacity-containing adenocarcinoma with a total diameter of ≤2 cm. Using a historical cohort, we identified histological aggressive components that were related to a poor prognosis in early-stage adenocarcinoma.
Although there is no evidence from prospective randomized controlled trials to support this practice, pulmonary metastases of sarcomas are often treated surgically if they are resectable. The purpose of this retrospective study was to evaluate the prognostic factors and outcome of pulmonary metastasectomy (PM) for soft tissue sarcomas (STSs) arising in the trunk wall and extremities in 66 consecutive patients. Prognostic factors associated with disease-specific survival after PM were evaluated using univariate and multivariate analyses.
View Article and Find Full Text PDFA cardiac herniation is a rare but life-threatening complication after pneumonectomy. In most cases, it manifests suddenly as severe hypotension and cardiac arrest within 24 h of pneumonectomy. Here, we report a case of sudden-onset cardiac herniation after right pneumonectomy during which the pericardium was incised.
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