Publications by authors named "Yosuke Masuda"

Objective: Identification of seizure focus on the interhemispheric fissure (IHF) is often challenging at the step of scalp video-EEG monitoring on preoperative evaluations. We previously reported ictal three-phase EEG patterns (3Ph-EEG) and isolated eye deviation (isolated ED) to side of the seizure focus during seizures, each of which is available for identifying the seizure focus for frontal IHF (F-IHF). This study aimed to evaluate the accuracy of predicting the F-IHF focus using a combination of 3Ph-EEG and isolated ED in patients with frontal lobe epilepsy and the accuracy of predicting lateralization of the F-IHF focus using the predominance of findings.

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Anorexia nervosa (AN) is a fatal condition associated with extreme underweight and undernutrition. It is more common in young females, with a female-to-male ratio of 10 : 1. Focal cortical dysplasia (FCD) is characterized by dysplasia of the cerebral cortex and is a common cause of pharmacoresistant epilepsy.

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Background: Traditional brain activity monitoring via scalp electroencephalography (EEG) offers limited resolution and is susceptible to artifacts. Endovascular electroencephalography (eEEG) emerged in the 1990s. Despite early successes and potential for detecting epileptiform activity, eEEG has remained clinically unutilized.

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Background Brain tumor patients tend to develop postoperative epileptic seizures, which can lead to an unfavorable outcome. Although the incidence of postoperative epileptic seizures and adverse events are improved with the advent of levetiracetam (LEV), postoperative epilepsy occurs at a frequency of 4.6% or higher.

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  • A multicenter retrospective cohort study in Japan investigated the impact of the COVID-19 pandemic on epilepsy care from January 2019 to December 2020, analyzing data such as outpatient visits, EEGs, and surgeries.
  • Findings showed a decrease in outpatient visits and EEG studies and a drastic increase in telemedicine use, with significant negative effects on admissions and procedures during periods of higher COVID-19 cases and a state of emergency.
  • The study highlights the substantial disruption to epilepsy care caused by the pandemic, corroborating previous research and emphasizing the extent of these changes.
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  • Researchers hypothesized that endovascular electroencephalogram (eEEG) can identify epileptiform discharges that are detectable by subdural electrodes (SDE) but not by scalp EEG.
  • The study involved a pig under anesthesia, where an eEEG measured artificially created epileptic activity and compared the timing of the discharges detected by both eEEG and SDE.
  • Results showed that the eEEG detected 97% of the epileptiform discharges, demonstrating its ability to identify specific electrical activity that traditional scalp EEG could not pick up.
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Objective: Few studies have examined the localization of seizures presenting with ictal eye deviation (ED) in the absence of other motor symptoms. We aimed to investigate differences in the localization of the ictal onset zone (IOZ) between patients with isolated ED and those with ED plus head turning (HT) during focal seizures.

Methods: We reviewed intracranial video-EEG data for 931 seizures in 80 patients with focal onset epilepsy in whom the IOZ could be confirmed.

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Background: To control brain tumor-related epilepsy (BTRE), both epileptological and neuro-oncological approaches are required. We hypothesized that using depth electrodes (DEs) as fence post catheters, we could detect the area of epileptic seizure onset and achieve both brain tumor removal and epileptic seizure control.

Methods: Between August 2009 and April 2018, we performed brain tumor removal for 27 patients with BTRE.

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Background: Hemispherotomy, which involves disconnecting hemispherical fibers, is a treatment option for medically intractable epilepsy. As various neurological disorders can cause strabismus, we hypothesized that hemispherotomy can cause post-operative strabismus in patients with medically intractable epilepsy.

Methods: Nineteen patients underwent the Hirschberg test before and after hemispherical disconnection surgery.

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Aim: Controlling epileptic seizures in elderly populations is widely considered to be relatively easy, but we hypothesized that the lifestyles of elderly individuals may affect the outcomes of epilepsy treatment. The purpose of this study was to review the activities of daily living (ADL) of elderly individuals with epilepsy and compare them with the outcomes of epilepsy treatment.

Methods: Of the 177 patients ≥65 years old who were referred to our epilepsy centre, epilepsy was diagnosed in 84.

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Background: Using a stereotactic technique, surgeons can accurately place a depth electrode (DE), but sometimes the DE deviates from the intended target due to movement of the electrode or leakage of cerebrospinal fluid when placing the electrode. If DEs can be anchored before removing the catheter insertion guide pipe, more accurate placement may be possible.

Methods: We made a side slit guide pipe.

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Background: This retrospective study is designed to determine whether the thickness of the corpus callosum can predict corpus callosotomy outcome in pediatric patients with epileptic or tonic spasms.

Methods: We retrospectively studied 25 patients (18 boys) with intractable childhood-onset epileptic or tonic spasms who underwent corpus callosotomy between March 2008 and January 2017. Seizure outcomes were classified as favorable (class I and II of Engel's outcome classification) or unfavorable (class III and IV of Engel's outcome classification) at 12 months postoperatively.

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Article Synopsis
  • Diagnosing epilepsy in elderly patients is challenging because symptoms can resemble other conditions, and it's believed that there are common clinical features specific to this age group.
  • A study analyzed 177 patients over 65 from 2009 to 2017, focusing on symptom types based on levels of consciousness and symptom duration.
  • Results indicated that short-duration symptoms (<1 minute) with impaired awareness are more likely to be epileptic in older adults, suggesting important diagnostic criteria for this population.
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Objective: MRI scans obtained within 48-72 hours (early postoperative MRI [epMRI]), prior to any postoperative reactive changes, are recommended for the accurate assessment of the extent of resection (EOR) after glioma surgery. Diffusion-weighted imaging (DWI) enables ischemic lesions to be detected and distinguished from the residual tumor. Prior studies, however, revealed that postoperative reactive changes were often present, even in epMRI.

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Purpose: Polymicrogyria, a malformation of the cerebral cortex, frequently causes epilepsy. Diffuse bilateral polymicrogyria (DBP) is related to poor epilepsy prognosis, but most patients with DBP are not good candidates for resective epilepsy surgery and effectiveness of corpus callosotomy (CC), a palliative surgery, for patients without resective epileptogenic cortices, has not been established in DBP. Because CC might be effective against DBP-related epilepsy, we conducted total CC in three pediatric DBP cases.

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  • The study explores the use of Gibbs free energy (ΔG) of hydrolytic water molecules in acyl-trypsin intermediates as a way to estimate the catalytic rate constants of reversible covalent inhibitors.
  • A new method was tested using a larger set of covalent ligands without available crystal structures, modeling acyl-trypsin structures and calculating ΔG and other molecular properties.
  • The research found that slower hydrolysis occurs with lower ΔG values and higher energy barriers, and demonstrated the potential of using ΔG and entropy calculations to optimize covalent inhibitor candidates effectively.
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Tumor angiogenesis has attracted increasing attention because of its potential as a valuable marker in the differential diagnosis of brain tumors as well as a novel therapeutic target. Prostate-specific membrane antigen (PSMA) is expressed by the neovasculature endothelium of some tumors, with little to no expression by the tumor cells or normal vasculature endothelium. The aim of this study was to investigate the potential of PSMA for the evaluation of the tumor neovasculature of various brain tumors and the possibility of detecting PSMA expression in brain tumors using PET imaging with Zr-Df-IAB2M (anti-PSMA minibody).

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In order to predict the potencies of mechanism-based reversible covalent inhibitors, the relationships between calculated Gibbs free energy of hydrolytic water molecule in acyl-trypsin intermediates and experimentally measured catalytic rate constants (k) were investigated. After obtaining representative solution structures by molecular dynamics (MD) simulations, hydration thermodynamics analyses using WaterMap™ were conducted. Consequently, we found for the first time that when Gibbs free energy of the hydrolytic water molecule was lower, logarithms of k were also lower.

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Background: We experienced a case of intraorbital pseudotumor associated with IgG4-related disease, for which we successfully performed an endoscopic endonasal transethmoidal biopsy for the intraorbital pseudotumor as well as endoscopic sinus surgery for a refractory pansinusitis at the same time.

Case Report: A 59-year-old man was referred to our hospital because of an intraorbital mass lesion. MRI showed 2 mass lesions:a large intraconal lesion encasing the left optic nerve on the orbital apex, and a small extraconal lesion medial to the left medial rectus muscle extending into the anterior ethmoid canal.

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Background: Carmustine (BCNU) wafer (Gliadel(®) Wafer) implantation after tumor resection is an approved treatment for high-grade glioma (HGG). These wafers change various characteristics on early postoperative magnetic resonance imaging (ep-MRI) including slight expansion of high-intensity areas on T2-weighted imaging (ep-T2-HIAs) into adjacent parenchyma without restricted diffusivity. We assessed the frequency of the ep-T2-HIAs after BCNU wafer implantation in HGG patients.

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Introduction: A high-field ceiling-mounted and movable intraoperative MR imaging (iMRI) can minimize additional risks for MRI and enhance safety by not moving the patient. In this system, hanging the heavy magnet from the ceiling requires structural stability; this stability was confirmed in earlier studies, but not proved during a seismic event.

Objective: We have installed a 1.

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Article Synopsis
  • The study aimed to find a suitable stimulus intensity for reducing variability in motor evoked potential (MEP) amplitudes during brain lesion removal surgeries.* -
  • Seventeen patients participated, with findings showing the coefficient of variation (CV) for MEP amplitudes decreased significantly at stimulus intensities of ST(0)+4 mA and was lowest at ST(0)+10 mA.* -
  • The threshold criterion exhibited less variability compared to the amplitude criterion, suggesting stronger stimulus intensities improve measurement consistency during intraoperative monitoring.*
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We herein present a case of bilateral chronic subdural hematoma(bilateral CSDH)caused by spontaneous intracranial hypotension(SIH)without orthostatic headache. A 67-year-old male patient with mild head injury suffered from a chronic, non-postural headache. Computed tomography of the brain showed bilateral CSDH.

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  • A case of a 33-year-old woman with Marfan syndrome is presented, who experienced trigeminal neuralgia due to compression from an elongated left vertebral artery.
  • After successful microvascular decompression surgery, her symptoms resolved, highlighting the need for neurosurgeons to consider unusual causes of trigeminal neuralgia that differ from typical cases.
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Intracranial nongerminomatous germ cell tumors (NGGCTs) in unusual locations are extremely rare. Here, we report a case of a yolk sac tumor in the frontal lobe in a middle-aged patient. A 42-year-old man was admitted to our hospital for headache and nausea.

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