Publications by authors named "Yoshiyuki Kuroyanagi"

Objective Asymptomatic renal immunoglobulin A (IgA) deposition occurs in healthy subjects, but its etiologic role in disease is unclear. Galactose-deficient IgA1 (Gd-IgA1) is involved in the pathogenesis of IgA nephropathy. We investigated Gd-IgA1 deposition in transplanted kidneys that were considered healthy showing subclinical latent IgA deposition one hour after transplantation.

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Background: Cervical lymphadenitis (CL) cannot be easily distinguished from Kawasaki disease (KD). We therefore explored whether brain natriuretic peptide (BNP) levels are useful in this context.

Methods: We retrospectively analyzed 14 children with CL and 177 children with KD.

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Article Synopsis
  • The study assessed how accurate insulin-like growth factor-1 (IGF-1) is for screening children for growth hormone deficiency (GHD), focusing on kids with short stature or slow growth.
  • Out of 298 examined children, only 60 were diagnosed with GHD, but IGF-1 levels did not show a significant difference between those with and without the deficiency.
  • The findings indicate that IGF-1 alone is not effective for GHD screening, suggesting the need for developing better predictive biomarkers.
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Article Synopsis
  • The study aimed to assess the effectiveness of procalcitonin (PCT) as a predictor for children with Kawasaki disease who do not respond to intravenous immunoglobulin (IVIG) treatment.
  • Analyzing data from 215 Kawasaki disease patients, the research revealed that higher PCT levels were significantly associated with IVIG resistance, with a median age of 2.4 years among the participants.
  • The findings suggest that a PCT cutoff value of 2.18 ng/mL could effectively identify non-responders to IVIG, showing high specificity (93.9%) and a decent sensitivity (46.4%).
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Background: The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines suggest initially using angiotensin-converting-enzyme inhibitors (ACE-Is) and/or angiotensin receptor blockers (ARBs) to treat Henoch-Schönlein purpura nephritis (HSPN). However, these guidelines might overlook the potential benefits of aggressive therapy. Therefore, we evaluated the efficacy of an HSPN protocol that primarily uses steroids and immunosuppressants, without ACE-Is or ARBs.

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Background: Toxic epidermal necrolysis (TEN) is a rare life-threatening condition almost exclusively attributed to drugs. The main etiologic factors for TEN are sulphonamides, anticonvulsants, and antibiotics; however, there are no published reports of warfarin causing TEN.

Case Presentation: We present the case of a 3-year-old patient who developed TEN while receiving treatment for Henoch-Schönlein purpura nephritis (HSPN).

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Background: High dose of cyclosporine (CyA) for ≥2 years in children with steroid-dependent nephrotic syndrome (SDNS) increases the risk for nephropathy. Considering this, risk can be lowered with lower doses of CyA; we evaluated the effects of a medium dose of CyA, with target serum level, C2, of 450 ng/ml, over a 2-year period of observation, to determine the need for follow-up kidney biopsy.

Methods: We retrospectively evaluated C2 levels in 38 patients (17 males, 5.

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Background: Anti-glomerular basement membrane (GBM) antibody disease is a rare autoimmune disorder characterized by rapidly progressive glomerulonephritis caused by autoantibodies against the α3-chain of type IV collagen in the GBM.

Case Presentation: An 8-year-old girl with hematuria and proteinuria due to anti-GBM nephritis was diagnosed with hematuria and proteinuria during a school urine screening program. Her blood pressure and serum creatinine levels were normal.

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A 9-year-old boy with pallor and macrohematuria showed hemolytic anemia, thrombocytopenia and renal failure. There was no history of diarrhea and the stool culture was negative. A diagnosis of atypical hemolytic uremic syndrome (HUS) was confirmed; however, the cause of the prolonged activated partial thromboplastin time (APTT) was unknown.

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