Publications by authors named "Yoshito Osugi"
Article Synopsis
- CKAP4 is a type II transmembrane protein located in the endoplasmic reticulum, and its knockout leads to changes in mitochondrial structures and increased contact sites between the ER and mitochondria in HeLaS3 cells.
- The binding of CKAP4 with VDAC2, a protein on the outer mitochondrial membrane, is essential for mitochondrial function, and this binding is dependent on CKAP4's palmitoylation.
- CKAP4 knockout results in disrupted mitochondrial activities such as increased Ca levels, reduced membrane potential, decreased oxidative consumption, and impaired cancer cell proliferation, which are not restored by a mutant form of CKAP4 that cannot be palmitoylated.
