Publications by authors named "Yoshitetsu Nagamine"

We present a case of a 44-year-old woman with rectal cancer(cT2N3M0, cStage Ⅲb)treated with 4 capecitabine-oxaliplatin( CAPOX)therapy courses, followed by laparoscopic intersphincteric resection. The patient received 7 postoperative, adjuvant CAPOX therapy courses. After 16 months since the final CAPOX administration, computed tomography(CT) revealed multiple liver tumors, showing early enhancement, and a jejunal mesenteric mass suspected to be a gastrointestinal stromal tumor(GIST).

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A 33-year-old man was admitted due to dyschezia and melena. Colonoscopy revealed a circulating type 4 rectal tumor. Further examination revealed intestinal obstruction due to rectal cancer, paraaortic lymph node metastasis, and multiple bone metastases, and an ileus tube was transanally inserted for decompression.

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Article Synopsis
  • Splenorenal shunts can lead to increased portal pressure and cause hyperammonemia, contributing to hepatic encephalopathy.
  • Recent studies suggest that oxaliplatin, a chemotherapy drug for colorectal cancer, may induce splenorenal shunts due to liver damage.
  • A case study of a 72-year-old man showed hyperammonemia following oxaliplatin treatment, leading to successful treatment with a procedure called BRTO and no recurrence of issues after 14 months.
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An 82-year-old man was referred to our hospital after a hepatic tumor was identified on ultrasonography.Computed tomography(CT)revealed a hypovascular tumor measuring 3 cm in diameter in the lateral section.He was diagnosed as having intrahepatic cholangiocarcinoma(ICC), and a left hemihepatectomy was performed in November 2012.

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Chemotherapy for advanced or recurrent colorectal cancer is standardized as oxaliplatin/5-FU/LV therapy (FOLFOX)and irinotecan/5-FU/LV therapy(FOLFIRI). It is difficult to introduce cancer chemotherapy to hemodialysis patients, and limited chemotherapeutics are available. The case was a 57-year-old man who was undergoing continuous hemodialysis when rectal cancer was found with multiple hepatic metastases.

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Article Synopsis
  • A 72-year-old woman with advanced gastric cancer was treated with a chemotherapy regimen including TS-1 and CDDP.
  • After the first round of treatment, she showed a partial response, leading to surgery for total gastrectomy.
  • Post-surgery, pathology revealed no cancer cells in the stomach and only a few lymph node metastases, and she has remained cancer-free for nearly 2 years.
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