Publications by authors named "Yoshitaka Kimoto"
Article Synopsis
- Remimazolam is an ultra-short-acting sedative approved in Japan for adults but lacks pediatric-specific guidelines, prompting this study on its safety for kids during procedures.
- The study included 48 children, averaging 7 years old, evaluating factors like dosage, procedure success, and changes in heart rate and blood pressure, with no adverse events reported.
- Results indicated that remimazolam, used alongside propofol or ketamine, is safe for pediatric procedural sedation, even though significant hemodynamic changes were observed; none required treatment for these fluctuations.
Article Synopsis
- Remimazolam, approved in 2020 for adult general anesthesia, is being tested for pediatric use in a study administering it alongside endotracheal anesthesia in children.
- Researchers analyzed medical records from 418 children, mainly around 4.6 years old, who underwent surgeries averaging about 81 minutes, using an adjusted dosing regimen from adult guidelines.
- The study found significant hemodynamic variability in many patients, with nearly half experiencing notable changes in mean arterial pressure, though patients recovered quickly, meeting discharge criteria within about 14 minutes post-anesthesia.
Circadian rhythms are biological rhythms with a period of around 24 hours. In this study, we compared the metabolome of the liver of medaka during the day and night. To comprehensively analyze the circadian variations in the levels of metabolites in the liver, livers were isolated from Zeitgeber time (ZT)4 and ZT16, and the variations in metabolite levels were evaluated.
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