A case of pathologically confirmed streptococcal infection-related IgA vasculitis with associated glomerulonephritis and leukocytoclastic cutaneous vasculitis.

We report the case of an 80 year-old woman who developed bilateral lower extremity purpura and renal impairment with proteinuria a few days after a transient fever (day 0). High levels of both anti-streptolysin-O antibody (ASO) and anti-streptokinase antibody (ASK), as well as low levels of coagulation factor XIII in serum were noted. Skin biopsy was performed and showed a leukocytoclastic vasculitis with deposition of IgA and C3 in the cutaneous small vessels, indicating IgA vasculitis in the skin.

Integrative treatment of paralytic small intestine following acute cervical cord injury: A case report.

Background: A patient developed paralysis of the small intestine following an acute traumatic hyperextension cervical spinal cord injury attributed to the ossification of the posterior longitudinal ligament (OPLL) C3-C6. The persistent ileus finally resolved utilizing Kampo medications (traditional Chinese therapy) consisting of both bukuryoin (TJ-69) and hangekobokuto (TJ-16).

Case Description: A 63-year-old male became acutely quadriplegic secondary to a hyperextension injury incurred during a fall.

Interleukin-36α as a potential biomarker for renal tubular damage induced by dietary phosphate load.

Excessive intake of phosphate has been known to induce renal tubular damage and interstitial inflammation, leading to acute kidney injury or chronic kidney disease in rodents and humans. However, sensitive and early biomarkers for phosphate-induced kidney damage remain to be identified. Our previous RNA sequencing analysis of renal gene expression identified interleukin-36α (IL-36α) as a gene significantly upregulated by dietary phosphate load in mice.

Growth hormone activates X-box binding protein 1 in a sexually dimorphic manner through the extracellular signal-regulated protein kinase and CCAAT/enhancer-binding protein β pathway in rat liver.

Growth hormone (GH) has multiple physiological roles, acting on many organs. In order to investigate its roles in rat liver, we tried to identify novel genes whose transcription was regulated by GH. We identified X-box binding protein 1 (Xbp1) as a candidate gene.

Flavanol-rich cocoa consumption enhances exercise-induced executive function improvements in humans.

Objective: Aerobic exercise is known to acutely improve cognitive functions, such as executive function (EF) and memory function (MF). Additionally, consumption of flavanol-rich cocoa has been reported to acutely improve cognitive function. The aim of this study was to determine whether high cocoa flavanol (CF; HCF) consumption would enhance exercise-induced improvement in cognitive function.

History and Evolution of Laminoplasty.

Techniques of expansive laminoplasty for degenerative cervical myelopathy and ossified posterior longitudinal ligament are described, focusing on the history of the surgical procedure. Laminectomy was the only approach for posterior decompression before Japanese orthopedic surgeons introduced laminoplasty from the 1970s to the 1980s to overcome the poor outcomes of laminectomy. Recent laminoplasty techniques offer less invasive maneuvers to the posterior cervical muscle structures to reduce axial neck pain and to obtain better functional outcome, but every operation is carried out based on the unchanged initial concept.

Initial radiological findings utilizing titanium basket for cervical open door laminoplasty.

Background: Cervical laminoplasty, utilizing different spacers to ''keep the door open,'' is the gold standard in Japan for treating ossification of the posterior longitudinal ligament (OPLL) and cervical spondylotic myelopathy (CSM). Here, we utilized a novel titanium ''basket'' spacer (Laminoplasty Basket: L-Basket; Ammtec, Tokyo) to perform open door cervical laminoplasty to keep the "door open" while also allowing for bony fusion across the open door.

Methods: Twenty-seven patients with/without OPLL were treated with open door laminoplasty utilizing the basket spacer.

Surgical management of symptomatic ossified anterior longitudinal ligament: A case report.

Background: Ossified anterior longitudinal ligament (OALL) of the cervical spine can cause dysphagia, dyspnoea, and dysphonia, although these symptoms are rare.

Case Description: A 71-year-old male presented with gradually progressive dysphagia secondary to OALL. He underwent fiber optic endoscopy and lateral video fluoroscopy.

Transition of a herniated lumbar disc to lumbar discal cyst: A case report.

Background: Another rare cause of lower back pain with radiculopathy is the discal cyst. It is believed to arise from degeneration of a herniated disc, although many other theories of its origin have been proposed. Here, we report a patient with lower back pain/radiculopathy attributed originally to a herniated lumbar disc, which transformed within 6 months into a discal cyst.

[Establishment of Endoscopic Spinal Neurosurgery and its Current Status].

Percutaneous endoscopic lumbar discectomy(PELD)has been used as a standard surgical technique for lumbar disc herniation at the Southern TOHOKU Healthcare Group since its introduction in 2009. We present our clinical experiences with PELD for 6 years and discuss the decision-making process for its surgical indication with a review of the pertinent literature. PELD can be performed under both local anesthesia and general anesthesia, and requires only a stab wound for surgery and 3 days of hospitalization.

Syncephalastrum racemosum amine oxidase with high catalytic efficiency toward ethanolamine and its application in ethanolamine determination.

Our screening study yielded a copper amine oxidase (SrAOX) from Syncephalastrum racemosum, which showed much higher affinity and catalytic efficiency toward ethanolamine (EA) than any other amine oxidase (AOX). Following purification of the enzyme to electrophoretic homogeneity from a cell-free extract, the maximum activity toward EA was detected at pH 7.2-7.

Width-controlled sub-nanometer graphene nanoribbon films synthesized by radical-polymerized chemical vapor deposition.

Radical-polymerized chemical vapor deposition, a new bottom-up method, was developed to produce graphene nanoribbons (GNRs) efficiently, despite the use of extremely low vacuum. Using this technique, a systematic synthesis of a multilayered high-density array of width-controlled sub-1 nm GNRs on a metal surface, with width-dependent band gap, is made possible. GNR films transferred onto insulating substrates behave as an excellent photoconductor.

Percutaneous endoscopic lumbar discectomy - early clinical experience.

We report our early clinical experience with percutaneous endoscopic lumbar discectomy (PELD) for herniated nucleus pulposus (HNP) in the lumbar spine. We introduced PELD to our clinical practice in June 2009. A total of 311 patients with degenerative lumbar spine disease were treated in our hospital up to August 2011.

Recapping hemilaminoplasty for spinal surgical disorders using ultrasonic bone curette.

Objective: The authors present a novel method of the recapping hemilaminoplasty in a retrospective study of patients with spinal surgical disorders. This report describes the surgical technique and the results of hemilaminoplasty using an ultrasonic bone curette. The aim of this study was to examine the safety and effectiveness of the hemilaminoplasty technique with ultrasonic bone curette.

Three-dimensional kinematic analysis of the cervical spine after anterior cervical decompression and fusion at an adjacent level: a preliminary report.

Purpose: Development of adjacent segment degeneration following anterior cervical decompression and fusion (ACDF) is still controversial, as adjacent-level kinematics is poorly understood. This study reports preliminary data from a high-accuracy 3D analysis technique developed for in vivo cervical kinematics.

Methods: From nine cervical spondylosis patients, four underwent single-level ACDF, and five underwent two-level ACDF using cylindrical titanium cage implant(s).

Spontaneous C1 anterior arch fracture as a postoperative complication of foramen magnum decompression for Chiari malformation type 1.

Background: C1 fracture accounts for 2% of all spinal column injuries and 10% of cervical spine fractures, and is most frequently caused by motor vehicle accidents and falls. We present a rare case of C1 anterior arch fracture following standard foramen magnum decompression for Chiari malformation type 1.

Case Description: A 63-year-old man underwent standard foramen magnum decompression (suboccipital craniectomy and C1 laminectomy) under a diagnosis of Chiari malformation type 1 with syringomyelia in June 2009.

[Concomitant intracerebral hemorrhage and cerebral infarction in moyamoya disease: a case report].

We encountered a case of moyamoya disease which exhibited intracerebral hemorrhage with intraventricular hemorrhage followed by cerebral infarction in a short time. A 39-year-old female presenting with sudden onset disturbance of consciousness was admitted to our hospital. Radiological investigation on admission revealed intracerebral hemorrhage in the left temporal lobe and intraventricular hemorrhage due to moyamoya disease.

β-Tricalcium phosphate promotes bony fusion after anterior cervical discectomy and fusion using titanium cages.

Study Design: Retrospective consecutive cohort study.

Objective: To study the effectiveness of β-tricalcium phosphate (β-TCP) granules as a packing material in the titanium cages for anterior cervical discectomy and fusion (ACDF), compared with the conventional hydroxyapatite (HA) granules.

Summary Of Background Data: ACDF using titanium cages is a standard procedure for the treatment of cervical spinal degenerative diseases.

New titanium spacer for cervical laminoplasty: initial clinical experience. Technical note.

Many commercially available hydroxyapatite (HA) spacers for cervical laminoplasty have been introduced but have disadvantages such as lack of plasticity, easy cracking, and occasional difficulty in fixation by sutures. Here we present the short-term results of a newly designed titanium spacer (Laminoplasty Basket) in open-door cervical laminoplasty, and evaluated clinically and radiologically. The titanium box-shaped spacer with two arms for fixation was easily inserted and fixed into the laminoplasty space with 4-mm or 5-mm length screws after the posterior cervical arch was repositioned for the canal expansion.

Minimally invasive central corpectomy for ossified posterior longitudinal ligament in the cervical spine.

Minimally invasive central corpectomy (MICC) for cervical segmental ossified posterior longitudinal ligament (OPLL) is described. The procedure of MICC includes upper- or lower-half central corpectomy of the involved cervical spine, transdiscal decompression of the adjacent disc level, dissection and partial removal of the OPLL, removal of the OPLL behind the vertebral body via these windows, and fusion with cylindrical titanium cages. Anterior plate fixation is not necessary.

Limaprost alfadex improves myelopathy symptoms in patients with cervical spinal canal stenosis.

Study Design: Myelopathy symptoms were prospectively studied in patients with cervical spinal canal stenosis (CSCS), using objective grading systems and stabilometry, to examine the effect of administration of prostaglandin E1 derivative limaprost alfadex (limaprost).

Objective: Myelopathy scores/grades and stabilometry parameters were evaluated before, and 1 and 3 months after starting the limaprost treatment.

Summary And Background Data: Limaprost is a potent vasodilator and antiplatelet agent and has been used to treat the symptoms of lumbar spinal canal stenosis.

Long term outcome and adjacent disc degeneration after anterior cervical discectomy and fusion with titanium cylindrical cages.

Background: Anterior cervical discectomy and fusion (ACDF) is widely performed for the treatment of cervical spinal degenerative disease. Autogenic or allogenic bone grafts are used for interbody fusion with satisfactory long term outcomes. However, harvest of the autograft causes donor site complications and allograft is associated with low fusion rate.

Negative pressure pulmonary edema following foramen magnum decompression for Chiari malformation type I.

A 57-year-old obese female presented with vagal and hypoglossal nerve pareses, and magnetic resonance imaging revealed Chiari malformation type I. Standard surgical treatment for Chiari malformation type I was successfully performed. However, immediately after the patient was extubated, she developed signs of upper airway obstruction and chest radiography revealed pulmonary edema.

Angiographically occult spinal dural arteriovenous fistula located using selective computed tomography angiography. Case report.

Spinal dural arteriovenous fistula (DAVF) is the most common type of spinal arteriovenous malformation and may cause progressive myelopathy but is usually treatable in the early stages by direct surgery or intravascular embolization. Selective spinal angiography has been the gold standard for diagnosis, but angiographically occult DAVF is not uncommon. A 67-year-old man presented with a 2-year history of progressive paraparesis.

Novel dural closure technique using polyglactin acid sheet prevents cerebrospinal fluid leakage after spinal surgery.

Objective: Extradural or subcutaneous cerebrospinal fluid (CSF) leakage is a common complication after spinal surgery and is associated with the risks of poor wound healing, meningitis, and pseudomeningocele. Numerous methods to prevent postoperative CSF leakage are available, but pressure-tight dural closure remains difficult, especially with synthetic surgical membranes. The efficacy of a novel dural closure technique was assessed by detecting extradural or subcutaneous CSF leakage on magnetic resonance imaging.