Publications by authors named "Yoshitaka Endo"
Article Synopsis
- The EXTRA study is the first research trial to explore predictive biomarkers for the effectiveness of afatinib in patients with specific mutations in nonsmall cell lung cancer (NSCLC) using various biological analyses.
- Conducted in Japan, the prospective study involved 103 untreated patients and measured metrics like progression-free survival (PFS) and overall survival (OS) while administering afatinib at an initial daily dose of 40 mg.
- Results showed that after a median follow-up of 35 months, the median PFS was 18.4 months, with a 3-year PFS rate of 23.3%, and a 3-year OS rate of 58.5%, indicating a positive response to afatinib in
Objective: We performed a retrospective observational study to demonstrate the surgical risks and long-term prognoses of intramedullary tumors in Japan using a multicenter registry authorized by the Neurospinal Society of Japan.
Methods: Data from 1,033 consecutive patients with intramedullary tumors, treated between 2009 and 2020, were collected from 58 centers. Patients with spinal lipomas or myxopapillary ependymomas were excluded.
Purpose: This study determined the effect of laser-assisted hatching on the clinical and neonatal outcomes of single vitrified blastocyst transfer.
Methods: From June 2014 to March 2018, 289 matched pairs after propensity score matching were analyzed. During the blastocyst warming procedure, a small section of the zona pellucida area in the empty perivitelline space was sliced off using multiple laser beams.
Purpose: Prolonged exposure to equilibration solutions may be detrimental to an embryo's developmental potential, whereas a shorter exposure may affect the penetration of cryoprotectants into blastomeres. The purpose of this study was to evaluate the effects of different equilibration times on the clinical and neonatal outcomes of human blastocyst vitrification.
Methods: This is a retrospective study based on data collected between November 2008 and November 2015.
Purpose: Limited research has been published on the effect of piezo-assisted intracytoplasmic sperm injection (P-ICSI). We evaluated the effect of P-ICSI on the laboratory, clinical, and neonatal outcomes.
Methods: This retrospective study was based on the data collected between April 2011 and October 2016.
Purpose: Microsuction (MS) is a technique for mechanically emptying fluid from blastocele using a microneedle. In this study, we evaluated the improvement in clinical and neonatal outcomes of vitrified blastocyst transfer programs when MS of blastocelic fluid was used before vitrification.
Methods: This was a retrospective study based on data collected between March 2014 and August 2016.