Publications by authors named "Yoshio Sogame"
Pancreatic ductal adenocarcinoma (PDAC) poses significant challenges due to its high mortality, making it a critical area of research. This retrospective observational study aimed to analyze real-world data from comprehensive genome profiling (CGP) of Japanese patients with PDAC, mainly focusing on differences in gene detection rates among panels and the implications for homologous recombination deficiency (HRD) status. This study enrolled 2568 patients with PDAC who had undergone CGP between June 2019 and December 2021 using data from the nationwide Center for Cancer Genomics and Advanced Therapeutics database.
View Article and Find Full Text PDFPathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors.
Acta Histochem Cytochem
April 2024
Article Synopsis
- Protein lactylation, a modification linked to glycolysis, plays a role in gene regulation, but its significance in cancer, especially pancreatic tumors, is still under investigation.
- The study found increased lactylation in the nuclei of various pancreatic tumors alongside elevated levels of hypoxia-inducible factor-1α, suggesting a connection with tumor hypoxia.
- Additionally, the chemotherapy drug gemcitabine was shown to decrease histone lactylation, indicating that protein lactylation might be a factor in pancreatic cancer development and treatment.
Article Synopsis
- MSI-H (microsatellite instability high) and TMB-high (tumor mutational burden high) types of pancreatic cancer are rare, with only 0.3% and 1.8% of patients, respectively, identified in a study of 2,206 patients with unresectable pancreatic adenocarcinoma.
- Patients with these subtypes exhibited specific genomic alterations, particularly involving mismatch repair genes and homologous recombination-related genes, but did not respond to chemotherapy, with no clinical responses recorded in MSI-H patients.
- The study highlights the need for tailored treatment strategies based on genomic characteristics, as MSI-H and TMB-high patients showed lower disease control rates compared to their microsatellite stable counterparts.
Article Synopsis
- This study focuses on rare subtypes of pancreatic cancer (ACC, ASC, ACP) and compares their clinical and genomic characteristics to the more common pancreatic ductal adenocarcinoma (PDAC) using the C-CAT database.
- Researchers analyzed data from 2,691 patients, finding that mutations in KRAS and TP53 were less common in ACC, while gene alterations related to homologous recombination were more prevalent in ACC compared to PDAC.
- The results also suggest that ACC patients might respond better to FOLFIRINOX treatment compared to GEM + nab-PTX, indicating distinct treatment efficacies based on tumor genomic differences.
Spontaneous regression in solid pseudopapillary neoplasm of pancreas.
Clin J Gastroenterol
February 2023
Article Synopsis
- A solid pseudopapillary neoplasm (SPN) of the pancreas is a rare tumor primarily found in young women, and a case of spontaneous regression is reported.
- A 48-year-old woman was diagnosed with a pancreatic mass after complaining of back pain, and various imaging studies characterized the tumor without significant abnormalities in enzyme levels or markers.
- After being advised for surgery, the patient opted for monitoring and, after one year, an MRI revealed that the tumor had spontaneously regressed, suggesting that hormonal changes related to menopause might influence SPN growth.
Article Synopsis
- * It can be challenging to differentiate primary pancreatic lymphoma from conditions like acute pancreatitis.
- * The reported case discusses an autopsy of a patient whose imaging results looked like severe acute pancreatitis, highlighting the important physical and microscopic details of the lymphoma.
Article Synopsis
- A study was conducted in Japan to validate the effectiveness of urinary trypsinogen-2 dipstick tests and other related markers in diagnosing acute pancreatitis.
- The research involved 94 patients and assessed the sensitivity and specificity of these markers alongside CT imaging criteria.
- The results confirmed that the urinary trypsinogen-2 dipstick test is a reliable diagnostic tool, and both urinary trypsinogen-2 and TAP levels can indicate the presence of inflammation outside the pancreas.
Aim: The purpose of this study was to clarify whether fatty pancreas might lead to impaired pancreatic endocrine or exocrine function.
Material And Methods: The study involved 109 participants who had undergone the glucagon stimulation test and N-benzoyl-L-tyros-p-amino benzoic acid (BT-PABA) test to assess pancreatic function as well as unenhanced abdominal computed tomography (CT). Pancreatic endocrine impairment was defined as ΔC peptide immunoreactivity less than 2 [mmol/L] in the glucagon stimulation test, and pancreatic exocrine impairment was defined as a urinary PABA excretion rate less than 70% on the BT-PABA test.
Nanoparticle albumin-bound paclitaxel(nab-PTX)was approved for the treatment of gastric cancer without a large-scale clinical trial in Japan. Its safety and efficacy should be validated in clinical practice. We retrospectively investigated prognostic factors related to time to treatment failure(TTF)in 11 patients with unresectable or recurrent gastric cancer treated with nab- PTX in our hospital.
View Article and Find Full Text PDFArticle Synopsis
- * The 2015 Clinical Practice Guidelines provide a comprehensive framework for diagnosing, staging, treating, and predicting outcomes of chronic pancreatitis, addressing 65 clinical questions.
- * These revised guidelines also incorporate recent evidence and new treatments, including options for managing early chronic pancreatitis and pancreatitis-related conditions, like pancreatic pseudocysts.
[A case of hypervascular hyperplastic nodule in chronic alcoholic liver disease with corona-like enhancement in the late phase image of CT during hepatic arteriography].
Nihon Shokakibyo Gakkai Zasshi
August 2009
A 46-year-old woman was admitted to our hospital with hepatic encephalopathy due to alcoholic liver disease. A hepatic nodule (20 mm in diameter) in S7 was enhanced in the early phase of contrast CT. No significant findings were observed in the late phase of contrast CT and SPIO MRI.
View Article and Find Full Text PDF[Antecedent medical imaging for the early detection of pancreas cancer].
Nihon Shokakibyo Gakkai Zasshi
August 2009
Kaposi's sarcoma is an uncommon neoplasm that occasionally involves the gastrointestinal tract in immunosuppressed individuals. Infection with human herpes virus 8 is known to be necessary for developing all forms of Kaposi's sarcoma. We report a renal transplant recipient who developed visceral Kaposi's sarcoma 18 months after the transplantation.
View Article and Find Full Text PDFContext: Acute pancreatitis is not commonly seen in the first presentation of pancreatic neoplasms. Solid pseudopapillary tumor as a cause of acute pancreatitis has not yet been reported. This is the first report of acute pancreatitis resulting from solid pseudopapillary tumor.
View Article and Find Full Text PDFObjectives: Increased dispersion of the QT interval has been proposed to be a novel marker for increased risk of ventricular arrhythmia and sudden cardiac death. This study examined whether QT dispersion is affected in patients with alcoholic pancreatitis.
Methods: We measured the QT interval, corrected QT interval, activation recovery interval, activation time, recovery time, and their respective dispersions in 3 age- and gender-matched groups: patients with alcoholic pancreatitis [age, 58.
Introduction: Pancreas secretes many enzymes for food digestion into the pancreatic juice. We cloned a novel serine protease, chymopasin, from rat pancreas.
Aims: To know the localization of this enzyme in the pancreas and to analyze the enzymatic characteristics.
Introduction: Because pancreatic exocrine function testing methods are problematic, both imaging and functional tests are important in the diagnosis of chronic pancreatitis.
Aim: To evaluate the usefulness of ultrasonographic monitoring of the main pancreatic duct after a secretin test.
Methodology: A total of 70 subjects (30 control subjects, 26 patients with probable chronic pancreatitis, and 14 patients with definite chronic pancreatitis) were selected.
Introduction: Duplex ultrasonographic technology is now capable of detecting flow signals in the various splanchnic vessels and calculating the concomitant flow velocities using fast-Fourier transformation.
Aim: To use Doppler sonography to investigate how splanchnic hemodynamics vary during the early stage of severe acute pancreatitis.
Methodology: Six patients with severe acute pancreatitis (age, 59.