Publications by authors named "Yoshio Nagayama"
Purpose: To evaluate the impact of prior teriparatide (TPTD) treatment on the effectiveness of romosozumab (ROMO) in postmenopausal osteoporosis.
Methods: In this retrospective, case-controlled, multicenter study, 323 postmenopausal patients were initiated ROMO. Of these, 275 were treatment-naïve, and 48 were switched from TPTD, with uninterrupted ROMO treatment for 12 months.
Unlabelled: The impact of ROMO on the width of anabolic windows and the increase in BMD was reduced in the RA group compared to the non-RA group, and this reduction was associated with correlations to RA-related factors.
Purpose: To investigate the effects of romosozumab (ROMO) in postmenopausal osteoporosis, with and without comorbid rheumatoid arthritis (RA).
Methods: In this retrospective, case-controlled, multicenter study, 171 postmenopausal patients who did not receive oral glucocorticoid, comprising 59 in the RA group and 121 in the non-RA group, received uninterrupted ROMO treatment for 12 months.
Article Synopsis
- Baseline serum PINP levels were found to be a significant predictor for improved bone mineral density (BMD) in the hip and femoral neck after 12 months of romosozumab (ROMO) treatment in postmenopausal women with osteoporosis.
- The study observed 63 patients, revealing significant improvements in lumbar spine BMD, but noted that more than half did not achieve the desired increase in hip and femoral neck BMD.
- The identified optimal baseline PINP cut-off value for predicting significant BMD increase was 53.7 µg/L, with high specificity and moderate sensitivity, indicating its potential usefulness in assessing treatment outcomes.
Background: The risk of osteoporosis in patients with rheumatoid arthritis (RA) is frequently overlooked, and investigating a simple indicator in routine care may be beneficial to motivate osteoporosis examination. The aim of this retrospective, case-controlled study was to identify the correlation between serum albumin concentrations and the prevalence of osteoporosis in postmenopausal patients with RA.
Methods: This study enrolled 197 patients who underwent dual-energy X-ray absorptiometry of lumbar spine (LS) and proximal femur without osteoporosis treatment [mean age, 67.
Objectives: To investigate the effects of prior treatment and determine the predictors of a 12-month treatment response of romosozumab (ROMO) in 148 patients with postmenopausal osteoporosis.
Methods: In this prospective, observational, and multicenter study, treatment naïve patients (Naïve; n=50) or patients previously treated with bisphosphonates (BP; n=37) or denosumab (DMAb; n=45) or teriparatide (TPTD; n=16) (mean age, 75.0 years; T-scores of the lumbar spine [LS] -3.
Article Synopsis
- The study investigates how different prior treatments affect the early response to romosozumab (ROMO) in postmenopausal osteoporosis patients.
- It includes 130 patients categorized by previous treatments (treatment-naïve, bisphosphonates, denosumab, or teriparatide) and measures changes in bone mineral density (BMD) and bone turnover markers over six months.
- Results show significant variations in lumbar spine BMD increases among groups, with earlier changes in specific bone markers predicting these responses.
Objectives: Tocilizumab (TCZ) shows good retention in patients with rheumatoid arthritis (RA), but no previous reports demonstrated hopeful treatment options against inadequate response to TCZ. Tacrolimus (TAC) has proved to show efficacy against inadequate response to tumor necrosis factor alpha inhibitors, yet its add-on effects on TCZ remain unknown.
Methods: Twenty patients with RA (17 women, age 58.
A 39-year-old female patient with rheumatoid arthritis developed Ramsay Hunt syndrome after infliximab treatment. This condition is caused by the reactivation of varicella zoster virus infection in the geniculate ganglion of facial nerve in the host's immunosuppression. She was treated immediately with valaciclovir and hydrocortisone, and the complete recovery was achieved at 6 months after the onset.
View Article and Find Full Text PDFWe propose a new interferometer concept that can realize electron-density distribution measurement with high spatial and moderate temporal resolution. The image non-radiative dielectric guide antenna can probe a wide measurement area simultaneously. We fabricated the antenna with an electromagnetic simulator and confirmed that the simulated and measured radiation patterns are consistent with each other.
View Article and Find Full Text PDFPlasma experiments on KSTAR are scheduled to start up this year (2008). We have developed an electron cyclotron emission (ECE) radiometer to measure the radial electron temperature profiles in KSTAR experiments. The radiometer system consists, briefly, of two downconversion stages, amplifiers, bandpass filter banks, and video detectors.
View Article and Find Full Text PDFReflectometry has been expected to be one of the key diagnostics to measure density profiles. We have applied an ultrashort-pulse reflectometry (USPR) system to Large Helical Device in the National Institute for Fusion Science. Wide frequency band system is required to obtain wide density profile since an incident wave is reflected at the density layer corresponding to its cutoff frequency.
View Article and Find Full Text PDF