Publications by authors named "Yoshio Koide"

Article Synopsis
  • - The study analyzed the impact of immunotherapy on 67 patients with unresectable stage IVB gastric cancer treated at Yarita Hospital, comparing outcomes from an early group (2016-2017) and a late group (2018-2022).
  • - Nivolumab was administered to 30% of patients, with a median overall survival of 11 months, showing longer survival in the early group compared to the late group (13 vs. 8.5 months). Transition rates to third-line treatments also increased from 22% to 33% over the study period.
  • - The findings suggest that the introduction of new therapies has improved treatment options for patients with advanced gastric cancer, indicating a trend towards better management
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The patient was a 66-year-old man with dysphagia. He underwent total gastrectomy and trans-hiatal abdominal esophagectomy with lymph node dissection, including the inferior mediastinum, for esophagogastric junction cancer. The postoperative pathological examination revealed poorly differentiated adenocarcinoma T4aN2, Stage ⅢA, HER2 negative, and postoperative adjuvant therapy S-1 oral administration was started.

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We present the case of a 55-year-old man with HER2-positive, AFP-producing gastric cancer and multiple liver metastases. The patient consequently underwent 7 courses of SOX plus trastuzumab therapy, 3 courses of weekly PTX plus ramucirumab therapy, and 3 courses of nivolumab therapy, all of which resulted in PD. Obstruction due to tumor growth became noticeable 9 months after the start of the first treatment.

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Background: Esophagostomy is important in the treatment of esophageal cancer. However, esophagectomy has a higher risk of postoperative complications. Treatment for complications is often difficult, and in some cases, oral intake is no longer possible.

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It is common these days to treat common bile duct (CBD) stones using endoscopic techniques. However, severe complications sometimes lead to death despite the great benefit of these techniques. If the patient has many and/or large stones, it can take considerable time for duct clearance, and this is associated with high costs.

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Stanniocalcin (STC) is a glycoprotein hormone that regulates calcium levels in fish. The related human protein stanniocalcin-1 (STC-1) is expressed in multiple organs including the ovary, prostate, kidney, and thyroid. Human STC-1 expression is enhanced by neural cell differentiation, bone formation, and cell proliferation.

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Lymphedema of the arm and hand is one of the major complications after a breast cancer resection. Conservative treatment for the treatment of lymphedema, such as compression garments and centripetal massage, is very important for these cases. However, if the lymphedema is difficult to control with conservative treatment and the patient's quality of life (QOL) is compromised due to swelling of the arms, surgical treatment should be considered.

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Stanniocalcin is a glycoprotein hormone that regulates the calcium level in fish. We found that mRNA of human stanniocalcin 1 (STC-1) is detectable in phytohemagglutinin-stimulated T cells and in most human leukemia cell lines, suggesting a role of STC-1 for cell proliferation. This finding prompts us to study the usefulness of STC-1 for monitoring acute leukemia.

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