Publications by authors named "Yoshio Kawaguchi"
Background: We established a community-based cohort study to assess the long-term impact of the Great East Japan Earthquake on disaster victims and gene-environment interactions on the incidence of major diseases, such as cancer and cardiovascular diseases.
Methods: We asked participants to join our cohort in the health check-up settings and assessment center based settings. Inclusion criteria were aged 20 years or over and living in Miyagi or Iwate Prefecture.
Article Synopsis
- Understanding allele frequencies of disease-related genetic variants is crucial for genomic medicine, but data for the Japanese population is currently lacking.
- The study analyzed pathogenic variants in 57 ACMG-recommended genes from a reference panel of 2049 individuals in Japan, identifying 143 reported pathogenic variants.
- Findings indicate that 21% of individuals possess at least one pathogenic allele, highlighting the need for a comprehensive review of genetic variants to advance genomic medicine infrastructure in Japan.
Background: With the goal of realizing genome-based personalized healthcare, we have developed a biobank that integrates personal health, genome, and omics data along with biospecimens donated by volunteers of 150,000. Such a large-scale of data integration involves obvious risks of privacy violation. The research use of personal genome and health information is a topic of global discussion with regard to the protection of privacy while promoting scientific advancement.
View Article and Find Full Text PDFThe Great East Japan Earthquake (GEJE) and resulting tsunami of March 11, 2011 gave rise to devastating damage on the Pacific coast of the Tohoku region. The Tohoku Medical Megabank Project (TMM), which is being conducted by Tohoku University Tohoku Medical Megabank Organization (ToMMo) and Iwate Medical University Iwate Tohoku Medical Megabank Organization (IMM), has been launched to realize creative reconstruction and to solve medical problems in the aftermath of this disaster. We started two prospective cohort studies in Miyagi and Iwate Prefectures: a population-based adult cohort study, the TMM Community-Based Cohort Study (TMM CommCohort Study), which will recruit 80 000 participants, and a birth and three-generation cohort study, the TMM Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study), which will recruit 70 000 participants, including fetuses and their parents, siblings, grandparents, and extended family members.
View Article and Find Full Text PDF[A case of early syphilitic hepatitis accompanied by intractable gastric ulcer].
Nihon Shokakibyo Gakkai Zasshi
November 2003