Publications by authors named "Yoshinori Sato"
Background: Despite accumulating evidence and recommendations for management of colonic diverticular bleeding (CDB), the changes in its clinical management and outcomes remain unknown.
Methods: We performed a retrospective tendency analysis on a biennial basis, a propensity score-matched cohort study between the first and latter half groups, and mediation analyses to compare the diagnostic and treatment methods between January 2010 and December 2019 (CODE BLUE-J Study).
Results: A total of 6575 patients with CDB were included.
Enhanced weathering of silicate minerals is a promising approach for reducing atmospheric CO levels by increasing the aquatic pH and facilitating CO dissolution. However, the slow and unsustainable dissolution of silicate minerals in natural environments remains a challenge. This study proposed a new CO capture system that uses the combined effect of amino acids and NaCl to promote mineral dissolution, and its characteristics were investigated experimentally.
View Article and Find Full Text PDFBackground And Aims: We sought to validate the British Society of Gastroenterology (BSG) guidelines for acute lower gastrointestinal bleeding (ALGIB).
Methods: We analyzed 8,956 patients with ALGIB in CODE BLUE-J study and categorized them into four groups based on BSG guidelines. Outcomes included 30-day rebleeding, 30-day mortality, blood transfusion, therapeutic intervention, and severe bleeding.
Article Synopsis
- - The study assessed how colonic diverticular bleeding (CDB) was managed and its clinical outcomes during the COVID-19 pandemic, comparing data from two time periods: before the pandemic (April 2017-March 2020) and during it (April 2020-March 2023).
- - A total of 388 hospitalized patients were analyzed using propensity score matching, revealing that while the overall number of colonoscopies remained similar, there was a notable decrease in early colonoscopies and those done outside regular hours during the pandemic.
- - Despite the reduction in early and after-hours colonoscopies, the risks of rebleeding or poor outcomes did not significantly increase during the pandemic, suggesting that patient outcomes
Article Synopsis
- Staphylococcus pseudintermedius, a zoonotic bacteria found in pets like dogs and cats, can cause bacterial infections, which led to a study on treating a cat with orbifloxacin for skin wounds.
- After 80 days of treatment, a resistant strain (novel sequence type ST 2660) was discovered in a severe abscess, showing resistance to multiple antibiotic classes and carrying harmful toxin genes.
- The isolate demonstrated strong biofilm formation ability at higher temperatures (39 °C), indicating an adaptation to body temperature, and this study marks the first report in Japan identifying the unique virulence of this strain in companion animals.
Article Synopsis
- The study focused on how Clostridioides difficile toxin B (TcdB), a key factor in C. difficile infections, impacts human neutrophils.
- TcdB disrupts neutrophil movement by affecting the organization of F-actin, which is crucial for their response to interleukin-8.
- By hindering neutrophil function, TcdB helps C. difficile evade the host's immune defenses, promoting the infection.
Article Synopsis
- The study examined the link between blood group O and the likelihood of rebleeding in patients with acute lower gastrointestinal bleeding (ALGIB).
- Out of 2336 patients analyzed, those with blood group O had higher rebleeding rates within 30 days (17.9%) and 1 year (21.9%) compared to non-O patients.
- Blood group O was found to be an independent risk factor for rebleeding, while rates of thrombosis and mortality were similar between groups.
Article Synopsis
- The study analyzed 8,254 cases of patients with acute lower gastrointestinal bleeding to find key factors that predict mortality and create a reliable prediction tool.
- Researchers established the CACHEXIA score, which uses factors present at admission and management during hospitalization to assess the risk of death within 30 days and 1 year.
- The CACHEXIA score demonstrated high accuracy (ROC-AUC 0.93 for 30 days; C-index 0.88 for 1 year) with significant differentiation of mortality risk, indicating that patients with high scores need continuous monitoring after discharge.
Background: The rebleeding risks and outcomes of endoscopic treatment for acute lower gastrointestinal bleeding (ALGIB) may differ depending on the bleeding location, type, and etiology of stigmata of recent hemorrhage (SRH) but have yet to be fully investigated. We aimed to identify high risk endoscopic SRH and to propose an optimal endoscopic treatment strategy.
Methods: We retrospectively analyzed 2699 ALGIB patients with SRH at 49 hospitals (CODE BLUE-J Study), of whom 88.
Multidrug-resistant Acinetobacter baumannii (MDRAB) is an important pathogen that causes nosocomial infections and is resistant to almost all antibiotics, including carbapenems. Cefiderocol is a novel siderophore cephalosporin active against a broad spectrum of gram-negative bacteria. However, the susceptibility of MDRAB to cefiderocol has not yet been reported in Japan.
View Article and Find Full Text PDFsp. nov., a heavy-metal-tolerant bacterium isolated from garden soil.
Int J Syst Evol Microbiol
January 2024
A previously undescribed, heavy-metal-tolerant, motile, Gram-negative bacterium, designated strain SK50-23, was characterized using a polyphasic approach. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain SK50-23 was closely related to LMG 26467 and the non-phototrophic '' NS23 (98.1 and 97.
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- A study analyzed data from 10,342 patients with acute lower gastrointestinal bleeding (ALGIB) to better understand surgical rates, procedures, and outcomes.
- Surgery was performed in only 1.3% of patients, with common indications being diverticular bleeding, colorectal cancer, and small bowel bleeding, and the overall mortality rate was 1.5% for those who underwent surgery.
- The findings suggest that identifying the source of bleeding and using endoscopic techniques may lower the need for surgery and enhance treatment for ALGIB.
Article Synopsis
- * Results showed that fewer endoscopic hemostasis procedures and second-look endoscopies were performed during the pandemic, while the average time from hospital arrival to endoscopy increased significantly.
- * Despite longer wait times for endoscopy during the pandemic, the outcomes in terms of mortality and rebleeding rates within 30 days did not show significant differences compared to the pre-pandemic period.
Article Synopsis
- This study compared the effects of early versus delayed feeding in patients with acute lower gastrointestinal bleeding (ALGIB) after their bleeding was controlled.
- Researchers analyzed data from 5,910 patients across Japan, dividing them into early (feeding within 1 day) and delayed (feeding after 2-3 days) groups.
- Results showed no significant differences in rebleeding rates or need for further treatments between the groups, but the early feeding group had a shorter hospital stay, suggesting it is a safe and beneficial practice.
Article Synopsis
- A study analyzed the impact of weekend admissions on outcomes for patients with acute lower gastrointestinal bleeding in 49 Japanese hospitals from 2010 to 2019.
- The findings showed no significant difference in mortality rates between weekend and weekday admissions, although weekend admissions resulted in a higher need for blood transfusions.
- Additionally, weekend admissions led to delays in early colonoscopy and an increase in urgent CT scans, but overall mortality and other outcomes remained unaffected.
Article Synopsis
- A predictive model called the LONG-HOSP score was developed to assess the risk of prolonged hospital stays for patients admitted with acute lower gastrointestinal bleeding (ALGIB), based on their baseline characteristics.
- The study analyzed data from over 8,500 patients across 49 hospitals to create and validate this model, which includes factors such as age, body mass index, and various lab results.
- Findings revealed that certain conditions and treatments during hospitalization, like colitis diagnosis and early colonoscopy, significantly impacted the length of stay, with early interventions helping to reduce it.
Article Synopsis
- This study compares the effectiveness of short vs. long attachment caps in colonoscopy for identifying causes of acute hematochezia, specifically looking at recent hemorrhage.
- Using data from over 6,400 patients, researchers found that long cap users had significantly higher rates of diagnosing colonic diverticular bleeding and identifying active bleeding, compared to short cap users.
- The conclusion suggests that long cap-assisted colonoscopy is more effective for diagnosing acute hematochezia and recognizing bleeding compared to short caps.
Article Synopsis
- Focal segmental glomerulosclerosis (FSGS) leads to kidney problems due to damage in podocytes, with specific genetic variants in the INF2 gene linked to different disease outcomes.
- The research analyzed how these INF2 variants affect cell structures, finding that those linked to Charcot-Marie-Tooth (CMT) and FSGS combined showed more severe cellular issues than those causing only FSGS.
- Findings suggest that the CMT/FSGS variants disrupt the organization of the cytoskeleton and organelle interactions more significantly than the variants responsible solely for monogenic FSGS, indicating a need for further research into specific cellular pathways.
(Ritter, 1910) (Zygentoma: Lepismatidae) is a primitive wingless insect that causes damage to paper, and it is regarded as a pest of collections in museums, archives, and libraries. This species was recently discovered in Japan for the first time and may have already spread over large areas of Japan, but, currently, no information is available on the biological characteristics of in Japan. In this study, we observed the processes of development and reproduction of found in Japan at room temperature.
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- A study analyzed long-term outcomes of 5048 patients hospitalized for acute lower gastrointestinal bleeding (ALGIB) in Japan to understand risks of recurrence after discharge.
- Findings revealed that 25.8% of patients experienced rebleeding within an average follow-up of 31 months, with significant mortality risks increasing for those with out-of-hospital rebleeding episodes.
- Key risk factors for rebleeding included shock index, blood transfusion, in-hospital rebleeding, colonic diverticular bleeding, and thienopyridine use, while endoscopic hemostasis was found to reduce rebleeding risk.
Objectives: This study aimed to determine the inhibitory and bactericidal effects of teicoplanin (TEC) on TEC-susceptible Staphylococcus haemolyticus isolated from a patient with cancer in whom infection persisted despite TEC therapy. We also focused on the biofilm-forming ability of the isolate in vitro.
Methods: S.
Single-walled carbon nanotubes (SWCNTs) modified by introducing non-six-membered ring defects, such as five- and seven-membered rings, have attracted considerable attention because their conductivity is enhanced by increasing the electronic density of states at the Fermi energy level. However, no preparation method exists to efficiently introduce non-six-membered ring defects into SWCNTs. Herein, we attempt to introduce non-six-membered ring defects into SWCNTs by defect rearrangement of the nanotube framework using a fluorination-defluorination process.
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- Metabolic activation is key to chemical toxicity, particularly in the liver, where the enzyme Cytochrome P450 2E (CYP2E) is crucial for substances like acetaminophen (APAP).
- Researchers developed transgenic zebrafish expressing rat CYP2E1 and EGFP to investigate toxicity, confirming CYP2E1 activity was linked to specific fluorescent changes.
- Findings showed that APAP reduces retina and liver sizes in zebrafish expressing CYP2E1 but not in those without it, while liver damage from APAP could be prevented with -acetylcysteine, indicating CYP2E1's role in certain toxic effects.
Article Synopsis
- - The study compared the effectiveness of two ligation therapies, endoscopic detachable snare ligation (EDSL) and endoscopic band ligation (EBL), in treating colonic diverticular bleeding (CDB) using data from 518 patients within a multicenter study.
- - Findings revealed no significant differences in outcomes like initial hemostasis, recurrent bleeding within 30 days, mortality, or need for additional interventions between the two treatment groups.
- - Sigmoid colon involvement and a history of acute lower gastrointestinal bleeding (ALGIB) were identified as significant risk factors for long-term recurrent bleeding, emphasizing the need for careful follow-up after ligation therapy.