Publications by authors named "Yoshinori Ohkura"
17α-ethinylestradiol (EE2), a derivative of 17β-estradiol (E2), is a potent estrogenic substance that is used as the estrogenic component of oral contraceptives (OCPs). However, women who take OCPs have an increased risk of cardiovascular events. Since few studies have examined EE2 endothelial effects, we explored the effects of EE2 on endothelial function in ovariectomized and isoflavone-free rats.
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- S-equol, a compound with estrogen-like effects, was studied to see how it affects blood vessel function and thickness in rats lacking isoflavones and estrogen.
- The study involved three groups of ovariectomized female rats: one with a regular diet (control), one without isoflavones (ID), and one without isoflavones but supplemented with S-equol (ID plus equol).
- Results showed that S-equol improved endothelial function and reduced intimal thickening in the arteries compared to the isoflavone-deficient group, highlighting its potential benefits in restoring vascular health.