Publications by authors named "Yoshinori Mitamura"
Article Synopsis
- Anti-VEGF therapy is the main treatment for neovascular age-related macular degeneration (nvAMD), and this study investigates factors influencing visual outcomes for treated patients.
- Conducted in Japan with 182 elderly patients, the study examines how age, baseline vision, and eye conditions affect visual acuity after one year of treatment with ranibizumab or aflibercept.
- Key findings reveal that younger age, absence of intraretinal fluid and pigment epithelial detachment, and lack of smoking or diabetes history can lead to better visual prognosis in nvAMD patients.
Article Synopsis
- The study aimed to evaluate the effectiveness of anti-VEGF therapy on visual acuity in patients with diabetic macular edema (DME) over two years.
- The research involved analyzing data from 1,780 eyes treated from 2015 to 2019, documenting changes in best-corrected visual acuity (BCVA) and treatment methods.
- Results showed a significant improvement in BCVA, with 73.3% of eyes maintaining good vision, highlighting anti-VEGF therapy as the preferred first-line treatment for DME.
Purpose: To evaluate the 2-year efficacy, durability, and safety of faricimab in patients with diabetic macular edema (DME) in the YOSEMITE Japan subgroup.
Study Design: YOSEMITE/RHINE (NCT03622580/NCT03622593) subgroup analysis: global, multicenter, randomized, double-masked, active-comparator-controlled, phase 3 faricimab trials.
Methods: Patients were randomized 1:1:1 to intravitreal faricimab 6.
Article Synopsis
- A global study has investigated the use of human pluripotent stem cell-derived retinal pigment epithelial cells (hiPSC-RPE) for treating diseases like age-related macular degeneration, highlighting the pros and cons of cell suspensions and sheets.
- The hiPSC-RPE strips were created to offer a less invasive method for cell delivery, demonstrating stable survival in a cynomolgus monkey model after transplantation into both damaged and healthy retinal areas.
- The transplanted RPE cells not only expanded more at the injury site without causing tumors but also exhibited important cellular characteristics for effective retinal therapy.
The utilization of a minimally invasively placed catheter-mounted intravascular micro-axial flow blood pump (IMFBP) is increasing in the population with advanced heart failure. The current development of IMFBPs dates back around the 1990s, namely the Hemopump with a wire-drive system and the Valvopump with a direct-drive system. The wire-drive IMFBPs can use a brushless motor in an external console unit to transmit rotational force through the drive wire rotating the impeller inside the body.
View Article and Find Full Text PDFPurpose: To determine whether combination of topical ripasudil and brimonidine has more effective neuroprotection on retinal ganglion cells (RGCs) following injury to axons composing the optic nerve.
Methods: Topical ripasudil, brimonidine, or mixture of both drugs were administered to adult mice after optic nerve injury (ONI). The influence of drug conditions on RGC health were evaluated by the quantifications of surviving RGCs, phosphorylated p38 mitogen-activated protein kinase (phospho-p38), and expressions of trophic factors and proinflammatory mediators in the retina.
Article Synopsis
- The study aimed to assess how fluctuations in foveal thickness (FTF) impact visual and structural outcomes over two years in patients with central retinal vein occlusion (CRVO) receiving anti-VEGF treatment for recurrent macular edema.
- A total of 141 treatment-naive patients were involved, and their foveal thickness was monitored using optical coherence tomography (OCT), categorized into four groups based on the degree of thickness fluctuation.
- Results indicated that while visual acuity improved for some groups with low foveal thickness fluctuation, patients with higher fluctuations experienced worsening vision and increased severity of the foveal ellipsoid zone defect, particularly those developing neovascular complications.
Article Synopsis
- A 75-year-old man with type-2 diabetes experienced sudden vision loss in his right eye one day after receiving the Pfizer-BioNTech SARS-CoV-2 vaccine.
- The diagnosis revealed branch retinal artery occlusion (BRAO) complicated by an unruptured retinal arterial macroaneurysm (RAM) seen during eye examinations.
- The case highlights a potential link between BRAO and COVID-19 vaccination, indicating a need for further research into this occurrence.
A higher serum vascular endothelial growth factor (VEGF) level can cause choroidal thickening in the choroid of patients with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome. We aimed to determine whether fluctuations in serum VEGF levels affect choroidal vascular structures in patients with POEMS syndrome. This retrospective observational case series examined 17 left eyes of 17 patients with POEMS syndrome.
View Article and Find Full Text PDFPurpose: Neovascular age-related macular degeneration (nAMD) is classified into typical AMD (tAMD), polypoidal choroidal vasculopathy (PCV), and retinal angiomatous proliferation (RAP). This study investigated clinical features of the 3 subtypes and visual outcome associated with treatment regimens in a large cohort of patients with nAMD in a clinical setting.
Design: Retrospective multicenter cohort study.
Purpose: The pathology of branch retinal vein occlusion (BRVO), a retinal circulatory disease, is related to monocular metamorphopsia-related vision impairment of the affected eyes, but the association of binocular metamorphopsia in such patients is unclear. This study aimed to examine the frequency of binocular metamorphopsia and its association with the clinical characteristics of patients with BRVO.
Methods: A total of 87 patients who were treated for BRVO-associated macular edema (ME) were included in this study.
Purpose: To evaluate efficacy, durability, and safety of faricimab in Japanese patients with diabetic macular edema (DME).
Study Design: Subgroup analysis of 2 global, multicenter, randomized, double-masked, active-comparator-controlled, phase 3 trials (YOSEMITE, NCT03622580; RHINE, NCT03622593).
Methods: Patients with DME were randomized 1:1:1 to intravitreal faricimab 6.
Purpose: To investigate age-specific prevalence of disease subtypes and baseline best-corrected visual acuity (BCVA) in Japanese patients with treatment-naïve neovascular age-related macular degeneration (nAMD).
Study Design: Retrospective multicenter case series.
Methods: We reviewed the records of patients with treatment-naïve nAMD who underwent initial treatment in 14 institutions in Japan sometime during the period from 2006 to 2015.
Importance: There is no widespread effective treatment to halt the progression of retinitis pigmentosa. Consequently, adequate assessment and estimation of residual visual function are important clinically.
Objective: To examine whether deep learning can accurately estimate the visual function of patients with retinitis pigmentosa by using ultra-widefield fundus images obtained on concurrent visits.
Purpose: We investigated potential risk factors for visual prognosis in Japanese patients with exogenous endophthalmitis.
Methods: In this retrospective observational multicenter cohort study, risk factors for legal blindness at 12 weeks after treatment initiation were evaluated based on patient characteristics, initial BCVA, causative events, pathogens, ocular symptoms, duration from symptom onset to initial treatment, and selected treatments.
Results: Overall, 23.
Anti-vascular endothelial growth factor (VEGF) therapy for diabetic macular edema (DME) improves visual acuity. However, repeated injections during routine outpatient visits are required to maintain this effect. The recent sudden global outbreak of coronavirus disease 2019 (COVID-19) had a major impact on daily life, including medical care, such as the provision of VEGF therapy.
View Article and Find Full Text PDFLaser therapy is the most effective treatment considered for retinopathy of prematurity (ROP). We compared the foveal morphology of the retina in eyes with a history of ROP to that of full-term children. This cross-sectional comparative study included 74 patients with a history of ROP, aged 4-6 years.
View Article and Find Full Text PDFPurpose: To evaluate the clinical characteristics, treatment trends, and visual prognosis of submacular hemorrhage (SMH) secondary to neovascular age-related macular degeneration (nAMD) and retinal arterial macroaneurysm (RAM).
Methods: This retrospective study enrolled 187 Japanese patients with SMH at 10 institutions from 2015 to 2018. Medical records including SMH etiology, best-corrected visual acuity (BCVA), fundus photographs, optical coherence tomography images, and selected treatments were analyzed.
Purpose: We investigated potential predictive factors for visual prognosis in Japanese patients with endogenous endophthalmitis.
Design: Retrospective observational multicenter cohort study.
Methods: We examined the characteristics of 77 Japanese patients with endogenous endophthalmitis and performed statistical analyses of these real-world data.
Purpose: To investigate the clinical features, treatment options, and visual outcomes of submacular hemorrhage (SMH) secondary to neovascular age-related macular degeneration (nAMD).
Design: A retrospective, observational case series.
Methods: Setting: Multicenter institutional setting.
In this article, we report two patients who experienced the first onset of branch retinal vein occlusion (BRVO) 3 days after the administration of the BNT162b2 (Pfizer-BioNTech) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. Case 1: A 50-year-old woman without any history of retinal disease developed vision loss in her right eye 3 days after receiving the first dose of the SARS-CoV-2 mRNA vaccine. Case 2: A 56-year-old woman without any history of retinal disease developed vision loss in her right eye 3 days after receiving the first dose of the SARS-CoV-2 mRNA vaccine.
View Article and Find Full Text PDFIn this study, we developed a new catheter-mounted micro-axial flow blood pump (MFBP) using a new miniature magnetic fluid shaft seal (MFSS). The prototype of the catheter-mounted MFBP had a maximum diameter of 8 mm and a length of 50 mm. The new MFSS composed a neodymium magnet ring, an iron ring, and a magnetic fluid particularly designed for the MFSS.
View Article and Find Full Text PDFAims/introduction: In older patients, the management of diabetic macular edema (DME) can be complicated by comorbidities, geriatric syndrome, and socioeconomic status. This study aims to evaluate the effects of aging on the management of DME.
Materials And Methods: This is a real-world clinical study including 1,552 patients with treatment-naïve center-involved DME.