Publications by authors named "Yoshinori Kosaki"

Article Synopsis
  • Obesity hypoventilation syndrome (OHS) leads to respiratory issues in obese patients, with complex challenges in critical care for those with extreme obesity, as seen in this case report.
  • A 39-year-old man with a body mass index (BMI) over 80 kg/m² faced severe respiratory distress due to OHS, pneumonia, and heart failure, requiring intensive medical interventions like intubation and mechanical ventilation.
  • Successful treatment involved a multidisciplinary approach focusing on tailored clinical practices, including managing fluid balance and nutrition, ultimately allowing the patient to recover and return home after 60 days of rehabilitation.
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Background: Grey-white matter ratio (GWR) measured by head computed tomography (CT) scan is known as a neurological prognostication tool for out-of-hospital cardiac arrest (OHCA) survivors. The prognostic value of GWR obtained early (within two hours after return of spontaneous circulation [ROSC]) remains a matter of debate.

Methods: We conducted a multicenter, retrospective, observational study at five hospitals.

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Background: Gray-to-white matter ratio (GWR), measured by computed tomography (CT), is commonly used to predict poor neurological outcomes after out-of-hospital cardiac arrest (OHCA). The prognostic performance of GWR in OHCA patients receiving extracorporeal cardiopulmonary resuscitation (ECPR) is not known.

Methods: This study is a secondary analysis of data from the SAVE-J II registry, a retrospective, multicenter study.

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Background: The clinical impact of signs of life (SOLs) in traumatic cardiac arrest (TCA) remains to be elucidated. The aim of this study was to examine the association between SOLs and survival/neurological outcomes in TCA patients.

Methods: Retrospective data from the Japan Trauma Data Bank (2019-2021) was reviewed.

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  • Massive methanol exposure can cause severe harm and potentially lead to death or brain death.
  • Patients with brain death from methanol ingestion are often seen as marginal organ donors, making recovery difficult.
  • This case highlights a successful multiple organ transplantation (heart, lungs, and kidneys) from a patient who suffered from methanol poisoning, showing that organ donation is still possible despite the intoxication.
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  • The study examined how different red blood cell transfusion strategies (restrictive vs. liberal) affect outcomes in trauma patients with varying lactate levels after injury.
  • In a post hoc analysis of the RESTRIC trial involving 396 participants, researchers found that mortality rates after 28 days were similar regardless of the transfusion strategy.
  • In patients with low lactate levels, the restrictive strategy was associated with more days free from ICU and ventilators, suggesting potential benefits of this approach for specific groups, despite similar survival rates.
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  • This study evaluated the effectiveness of restrictive versus liberal red blood cell transfusion strategies in patients with severe trauma to see which approach led to better survival rates during the acute post-injury phase.
  • Conducted in Japan, the trial involved 22 hospitals and compared transfusion target hemoglobin levels of 7-9 g/dL in the restrictive group to 10-12 g/dL in the liberal group, measuring outcomes like 28-day survival, transfusion volume, and complications.
  • Results showed no significant difference in 28-day survival rates (92.1% for restrictive vs. 91.3% for liberal), nor in complication rates, but the restrictive group required lower transfusion
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Background: Sudden loss of consciousness as a result of cardiac arrest can cause severe traumatic head injury. Collapse-related traumatic intracranial hemorrhage (CRTIH) following out-of-hospital cardiac arrest (OHCA) may be linked to poor neurological outcomes; however, there is a paucity of data on this entity. This study aimed to investigate the frequency, characteristics, and outcomes of CRTIH following OHCA.

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Seat belts with shoulder restraints have decreased the frequency of life-threatening severe chest trauma caused by car accidents. However, the introduction of seat belt legislation has led to an increase in a specific pattern of blunt trauma known as seat belt syndrome, which includes rib, clavicle, spine, and sternum fractures, as well as rupture of hollow pelvic and abdominal viscera, mesenteric tears, and major vessel injuries. The shoulder restraint part of the three-point seat belt commonly rests near or over the female and male breast.

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Background: Myxedema coma is an extremely rare but fatal endocrine emergency that requires urgent recognition and treatment. We describe a case of severe hypothermia that rapidly deteriorated to cardiac arrest that was attributed to myxedema coma.

Case Presentation: A 52-year-old man without a history of hypothyroidism was transferred to our emergency department due to coma and profound hypothermia.

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Basic life support (BLS) courses for laypersons, including cardiopulmonary resuscitation (CPR) training, is known to improve outcomes of out-of-hospital cardiac events. We asked medical students to provide BLS training for laypersons as a part of their emergency medicine education and evaluated the effects of training on the BLS skills of laypersons. We also used a questionnaire to determine whether the medical students who provided the BLS training were themselves more confident and motivated to perform BLS compared to students who did not provide BLS training.

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Article Synopsis
  • The COVID-19 pandemic has severely affected the healthcare system, contributing to increased burnout among healthcare workers (HCWs), especially those directly involved in patient care.
  • A study conducted at a Japanese university hospital revealed that the burnout rate among HCWs caring for COVID-19 patients was highest during surges, with 50.0% in late 2020 and varying percentages in early 2021.
  • The research highlights the need for better support and interventions for HCWs due to ongoing challenges like stigma and emotional strain during the pandemic.
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Acute carbon monoxide (CO) intoxication during pregnancy causes fetal death and teratogenic effects. Hyperbaric oxygen (HBO2) therapy has the potential to improve them. HBO2 therapy should be considered to treat CO intoxication during pregnancy.

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The coronavirus disease 2019 (COVID-19) global pandemic has drastically changed how we live and work. Amid the prolonged pandemic, burnout of the frontline healthcare professionals has become a significant concern. We conducted a cross-sectional survey study to provide data about the relationship between the COVID-19 pandemic and the prevalence of burnout in healthcare professionals in Japan.

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The ginkgo tree is a well-known, highly adaptable urban plant. Ginkgo nuts are the product of the ginkgo tree. Interior ginkgo nuts are cooked and served in Asian countries; however, the potential toxicity of the gingko nuts is not commonly known.

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Although fatalities due to caffeine intoxication are uncommon, a caffeine overdose may cause profound toxicity, resulting in tachycardia, arrhythmia, convulsions, vomiting, coma, and possibly death. In particular, high caffeine consumption while pregnant can cause increased fetal catecholamine levels, which could lead to increased fetal heart rate and placental vasoconstriction and impair fetal oxygenation. Therefore, caffeine intoxication in pregnant women should be treated immediately.

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Emphysematous cystitis is an uncommon acute infection of the underlying bladder musculature and mucosa, caused by gas-producing organisms. Here we describe an 87-year-old woman with diabetes mellitus and emphysematous cystitis who was successfully treated with hyperbaric oxygen (HBO2) therapy. Her predisposition of diabetes and infection with gas-producing bacteria was considered to precede the development of emphysematous cystitis.

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A healthy 10-year-old boy vomited during sleep and later complained of abdominal pain; he became drowsy and uncommunicative. At the nearby hospital E.R.

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The primary toxicity of hydrogen peroxide results from its interaction with catalase, which liberates water and oxygen. We report the case of a 14-year-old Japanese girl with portal venous gas that was caused by oxygen liberated from intentionally ingested hydrogen peroxide. Although she had a past history of atrial septal defect, recovery without cardiac or neurological sequelae was achieved using hyperbaric oxygen therapy.

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Objective: We tested whether Cushing's sign could predict severe traumatic brain injury (TBI) requiring immediate neurosurgical intervention (BI-NSI) in children after blunt trauma.

Design: Retrospective cohort study using Japan Trauma Data Bank.

Setting: Emergency and critical care centres in secondary and tertiary hospitals in Japan.

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Traumatic eyeball luxation is a rare clinical condition with a dramatic presentation. Here, we describe a unique case of traumatic globe luxation and complete optic nerve transection caused by heavy object compression. A 45-year-old male automobile mechanic was injured when a truck slipped from its supports, crushing his head and face.

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Worldwide, hemorrhagic shock in major trauma remains a major potentially preventable cause of death. Controlling bleeding and subsequent coagulopathy is a big challenge. Immediate assessment of unidentified bleeding sources is essential in blunt trauma patients with hemorrhagic shock.

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