Publications by authors named "Yoshinobu Matsuda"
Background: Serum C-reactive protein (CRP) levels are correlated with patient outcomes in cancer. This study aimed to determine associations between the CRP level and the dietary intake, symptoms, and eating-related distress (ERD).
Methods: We conducted a multicenter survey among advanced cancer patients.
Background: Delirium is a condition characterized by an acute and transient disturbance in attention, cognition, and consciousness. It is increasingly prevalent at the end of life in patients with cancer. While non-pharmacological nursing interventions are essential for delirium prevention, their effectiveness in terminally ill patients with cancer remains unclear.
View Article and Find Full Text PDFArticle Synopsis
- Delirium alters cognitive function and may impact the severity of physical symptoms like pain and dyspnea in palliative care patients, but the specific effects of different motor subtypes of delirium are not fully understood.
- A study analyzed patient data from 23 hospices in Japan, focusing on advanced cancer patients who experienced delirium and its motor subtypes at the time of admission and later on.
- Results indicated that patients with hyperactive or mixed delirium had significantly higher odds of experiencing severe pain and dyspnea compared to those without delirium, while hypoactive delirium did not show a similar association.
Rationale: Accurate prognostic awareness (PA) and knowledge of the disease are critical for decision-making regarding treatment options, advance care planning, and end-of-life care. However, they have not been investigated in patients with interstitial lung disease (ILD).
Objectives: To determine the prevalence of patients with ILD who have accurate PA and/or knowledge of acute exacerbation.
Purpose: This study explores the use of nursing support among nurses for caregiver burden in family caregivers of terminally ill patients with cancer in palliative care units (PCUs).
Methods: Requests were sent to 389 institutions, and cooperation was received from 162 PCUs. Nurses at 162 PCUs were asked to participate in an Internet survey regarding nursing practices for caregiver burden in Japan.
Article Synopsis
- A new method called the WPCBAL score was developed to predict short-term patient prognosis using only six clinical tests, but it hasn't been compared with established methods before.
- This study aimed to evaluate the WPCBAL score's effectiveness by comparing it with other recognized prognostic tools in a group of patients in a palliative care unit in Japan.
- Results showed that the WPCBAL score has comparable accuracy for predicting 2- or 3-week prognosis, suggesting it may be a useful short-term prognostic tool alongside existing methods.
Background And Purpose: Dyspnea in patients with terminal cancer worsens near death, necessitating effective nonpharmacological management. Despite guideline recommendations, detailed studies on nonpharmacological nursing practices are scarce. This study aimed to elucidate nursing practices for dyspnea in patients with cancer based on monthly and weekly prognoses.
View Article and Find Full Text PDFObjective: The aim of this study was to evaluate the efficacy and safety of a single trigger point injection (TPI) of a local anesthetic for the treatment of myofascial pain syndrome (MPS) in patients with incurable cancer.
Methods: This multicenter, exploratory, open-label, randomized comparative trial was conducted in five specialized palliative care departments. Hospitalized patients with incurable cancer who had been experiencing pain related to MPS were randomized to receive either a TPI of 1% lidocaine plus conventional care (TPI group) or conventional care alone (control group).
Background/aim: Pneumonitis during durvalumab consolidation therapy after chemoradiotherapy (CRT) is a major cause of treatment discontinuation. Although previous studies have revealed an association between antinuclear antibody (ANA) positivity and the safety and efficacy of immune checkpoint inhibitors in advanced non-small cell lung cancer (NSCLC), there are no reports on durvalumab consolidation therapy. This study investigated the safety and efficacy of durvalumab after CRT in ANA-positive patients.
View Article and Find Full Text PDFConstipation is an uncomfortable symptom experienced by many patients with advanced cancer, and it decreases the quality of life. Several studies have advised pharmacological therapies for constipation management, whereas others have promoted nonpharmacological approaches that promote changes in the patient's lifestyle. However, constipation management by nurses has not yet been systematically reviewed in patients with cancer.
View Article and Find Full Text PDFDyspnea is one of the most common and distressing symptoms in patients with cancer and noncancer advanced diseases. The Japanese Society for Palliative Medicine revised previous guidelines for the management of respiratory symptoms in patients with cancer and newly developed clinical guidelines for managing dyspnea in patients with advanced disease, based on the result of systematic reviews for each clinical question and consensus among experts. We describe the recommendations of the guidelines as well as provide insights into the reasoning behind the recommendations and their development process.
View Article and Find Full Text PDFPurpose: In this study, we aimed to evaluate the safety and effectiveness of naldemedine for treating opioid-induced constipation (OIC) in patients with advanced cancer, who are receiving palliative care, and particularly explored its early effects.
Methods: Palliative care teams and inpatient palliative care units across 14 institutions in Japan were included in this multicenter, prospective, observational study. Patients who were newly prescribed a daily oral dose of 0.
Article Synopsis
- Advanced cancer patients often experience nutrition impact symptoms (NISs) and depressive moods, which this study aimed to explore.
- The study analyzed 225 palliative care patients, dividing them into non-depression and depression groups based on their scores from the Patient Health Questionnaire-9 (PHQ-9).
- Results showed a significant relationship where depression was linked to a higher number and severity of NISs, indicating that having four or more severe NISs is associated with an increased risk of depression.
Article Synopsis
- The study aimed to explore the relationship between patients' unrealistic expectations of chemotherapy as a cure and their understanding of being informed about the incurability of their cancer.
- Researchers analyzed data from 200 patients with non-small cell lung cancer and found that while most oncologists believed they communicated incurability, many patients did not perceive this disclosure.
- Patients who maintained unrealistic expectations about chemotherapy were less likely to receive specialized palliative care, indicating a link between understanding their prognosis and the care they received.
Background: This report investigates the applicability of nursing support for patients with cancer with a prognosis of months and weeks, and their families.
Objectives: To evaluate the applicability of nursing support for five symptoms (dyspnea, pain, nausea/vomiting, constipation, and delirium) in patients with cancer during the last weeks of life, and the caregiver burden on their families.
Design Setting: A Delphi study was used to determine the applicability of nursing support for patients with terminal cancer and their families.
Objectives: Dyspnoea is a common and distressing symptom in patients with cancer. We aimed to analyse the association between dyspnoea and related factors and to estimate their causal relationship.
Methods: A cross-sectional study was conducted.
Background & Aims: There is no definition of nutrition impact symptoms (NISs) in cancer care. Moreover, there is a lack of evidence on the associations of NISs with dietary intake and eating-related distress (ERD) in advanced cancer. Therefore, this study aimed to determine the associations of NISs with dietary intake and ERD in patients with advanced cancer.
View Article and Find Full Text PDFPain is subjective, warranting tailored responses in pharmacotherapy and nursing support. Despite this, the evidence for suitable nursing support for pain is not well established in terminally ill patients such as those with cancer; therefore, it is necessary to provide support in consideration of changes in physical symptoms and quality of life. However, interventional studies for such patients are often difficult.
View Article and Find Full Text PDFNausea and vomiting are symptoms commonly experienced by patients with advanced cancer and have a wide range of causes, including pharmacological interventions. Additionally, multiple factors often simultaneously cause nausea and vomiting. These highly distressing symptoms may be directly or indirectly related to the disease and can significantly impact both the physical and psychological well-being of patients.
View Article and Find Full Text PDFBackground: Next-generation sequencing (NGS) analysis is becoming indispensable for the treatment of advanced lung cancer. NGS analysis requires a large number of cancer cell-containing tissues; however, it is often difficult for small biopsies to obtain the required quantities. In microdissection, only the tumour parts of a tissue specimen are obtained, which thereby increases the tumour content and tumour cell count of the tissue specimen.
View Article and Find Full Text PDFTo identify nursing support for caregiver burden in family caregivers of patients with cancer. This scoping review was guided by Arksey and O'Malley's six-stage scoping review framework. All available published articles from database inception to July 31, 2023 were systematically searched through PubMed, CINAHL, CENTRAL, and Ichushi-Web of the Japan Medical Abstract Society databases with additional relevant studies from the article list.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to explore the nursing support available for patients with cancer suffering from breathlessness.
- Researchers conducted a scoping review, analyzing 2629 articles and ultimately including 27 that met criteria regarding nursing interventions and breathlessness assessments.
- The findings highlighted 12 effective nursing support methods, such as fan therapy, breathing techniques, and yoga, which could improve care for patients experiencing breathlessness due to cancer.
Context: μ-opioid receptor gene (OPRM1) A118G polymorphism (rs1799971) causes loss of N-glycosylation sites at the extracellular domain of μ-opioid receptors. G-allele carriers show a limited response to morphine; however, studies investigating the impact of A118G polymorphism on the efficacy of opioids other than morphine are limited.
Objective: To compare the impact of A118G polymorphism on the efficacy of various opioids.
Article Synopsis
- Osteoblastic bone reaction (OBR) is often mistaken for disease progression in patients with bone metastasis, particularly in those treated for EGFR-mutant non-small cell lung cancer (NSCLC) with osimertinib.
- A study reviewing 45 patients found that 82% experienced OBR, especially in those with existing sclerotic lesions, with no significant difference in progression-free survival between groups with and without OBR.
- OBR was identified as a significant predictor of longer skeletal-related events-free survival; patients with OBR had a trend toward better outcomes compared to those without it.