Publications by authors named "Yoshinobu Hirose"
Granular cell tumors (GCTs) are relatively rare, whereas malignant GCTs are extremely rare. This brief report describes a cytological case of metastatic malignant GCT in the lymph node with immunocytochemical analysis. A 77 years old Japanese female with a history of surgical resection for malignant GCT in the back 8 years earlier presented with swelling of the right neck.
View Article and Find Full Text PDF: Adipophilin (ADP) is a protein associated with lipid droplets, and its expression is related to poor prognosis in certain cancers. However, its impact on the survival of patients with colorectal liver metastases (CRLMs) remains unclear. This study investigated the impact of ADP expression on long-term survival following hepatectomy in patients with CRLM.
View Article and Find Full Text PDFPulmonary arterial hypertension (PAH) is a progressive condition that frequently leads to right ventricular (RV) remodeling. Aldosterone promotes vascular and RV remodeling. The upregulation of steroidogenic acute regulatory protein (StAR) stimulates aldosterone synthesis.
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- Intravascular large B-cell lymphoma (IVLBCL) is a rare cancer where lymphoma cells grow exclusively within blood vessels, making diagnosis challenging due to the absence of typical swollen lymph nodes or tumors.
- The study discusses the 21st documented case of IVLBCL associated with a cherry angioma in an 82-year-old man, highlighting the importance of skin biopsies for proper diagnosis.
- Findings from the biopsy showed abnormal lymphoid cells within the cherry angioma, revealing key immunohistochemical markers, which confirm the utility of skin biopsies in detecting IVLBCL, despite there being limited previous case reports.
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- Scientists studied a gene in zebrafish that helped them understand changes in a body part called the neuromuscular junction, especially in mutant fish that couldn't move.
- They discovered this gene is similar to other genes found in humans that help fight off bacteria and is part of a larger group of related genes in zebrafish.
- The researchers found that this gene helps young zebrafish survive better against infections, especially when they live in clean environments without germs.
Hyper progressive disease (HPD) is a paradoxical phenomenon characterized by accelerated tumor growth following treatment with immune checkpoint inhibitors. However, the pathogenic causality and its predictor remain unknown. We herein report a fatal case of HPD in a 50-year-old man with metastatic bladder cancer.
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- - Mesenteric panniculitis (MP) is a rare inflammatory condition affecting the mesentery, often linked with chylous ascites and occasionally with protein-losing enteropathy (PLE), a condition causing significant protein loss from the intestines.
- - A recent case at Osaka Medical and Pharmaceutical University involved a 56-year-old male who presented with severe symptoms including dyspnoea, systemic edema, and weight loss, ultimately diagnosed with MP alongside massive chylous pleural effusion and PLE.
- - Despite initial treatment with prednisolone and antibiotics, the patient deteriorated and died from respiratory failure, leading to a post-mortem confirming MP with severe complications, emphasizing the need to consider MP in
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- Prognostic stratification for colorectal cancer (CRC) patients is crucial, with the desmoplastic reaction (DR) potentially reflecting the tumor microenvironment and serving as a new prognostic indicator not previously included in existing nomograms.* -
- The study evaluated 329 CRC patients post-surgery to develop a new scoring system based on histopathological indicators such as tumor glandular differentiation, tumor budding, and lymph node metastasis.* -
- Findings indicated that the new D&M scoring system significantly improved predictions of disease-specific survival and recurrence-free survival compared to the current American Joint Committee on Cancer staging system, suggesting its potential as a valuable prognostic tool.*
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- Lymphoepithelial cysts (LECs) are rare, non-cancerous lumps that can form in the salivary glands and are surrounded by special tissue called lymphoid tissue.
- Diagnosing these cysts before surgery using a technique called fine-needle aspiration (FNA) can be tricky because sometimes they don’t show important cells in tests.
- A study looked at 13 patients with LECs and found that using the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) could help doctors better understand these cysts even though identifying them was tough.
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- Tailgut cysts are rare cysts found near the rectum and can develop into tumors, but it's not fully understood how this happens.
- A study looked at four patients with tailgut cysts, focusing on their symptoms and how the cysts looked under imaging and when examined in the lab.
- In two patients, abnormal cell changes (dysplasia) were found, which might lead to a more serious cancer called adenocarcinoma, highlighting the need for surgery to remove these cysts.
Bronchogenic cysts are congenital malformations of the bronchial tree, detected as a cystic and/or mass lesion in the thoracic cavity. Although it occurs in distant locations, such as skin and retroperitoneum, to the best of our knowledge, little is known about the components and phenotypes of the epithelium that line a bronchogenic cyst in rare sites. The present study reviewed 34 bronchogenic cysts that were surgically resected at Osaka Medical and Pharmaceutical University Hospital (Osaka, Japan) from January 1998 to December 2020.
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- * This study investigated the expression of the cancer/testis antigen PRAME in patients with CIS, which had not been extensively researched before.
- * Results showed that PRAME was expressed in 43.4% of patients with CIS, suggesting it could be a valuable diagnostic marker and a potential therapeutic target for difficult-to-treat cases.
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- There is currently limited understanding of how alterations in fibroblast growth factor receptor 3 (FGFR3) affect bladder cancer (BLCA) and its tumor microenvironment (TME).
- A study involving multi-omics analysis of BLCA tissues showed that aFGFR3 alterations are found in 44% of non-muscle invasive cases and 15% of muscle-invasive cases, affecting their immune response and tumor characteristics.
- Notably, the LumP subtype in aFGFR3 cases responded significantly better to checkpoint inhibitors compared to their intact FGFR3 counterparts, suggesting that FGFR3 status influences treatment outcomes in bladder cancer.
Article Synopsis
- - The study examines whether the histological glandular differentiation (HGD) score is predictive of survival for patients with intrahepatic cholangiocarcinoma (ICC) after surgery.
- - An analysis of 235 patients showed that those with high HGD grades had significantly shorter median disease-free survival (13.0 months) compared to those with moderate HGD grades (31.2 months), indicating that HGD grade is an important factor in patient outcomes.
- - The findings suggest that HGD grade is a valuable prognostic indicator, alongside other factors like vascular invasion and tumor size, for predicting early recurrence in ICC patients after hepatectomy.
Objective: High-grade parotid carcinoma generally has a poor prognosis, and the histological type is mucoepidermoid carcinoma (MEC), salivary duct carcinoma (SDC), carcinoma ex pleomorphic adenoma (CEPA), or adenoid cystic carcinoma (AdCC) in the majority of cases.
Methods: During the 23-year period from September 1999 to December 2022, 250 patients with parotid carcinoma underwent initial treatment and had the histopathological type of their carcinoma. Retrospective study evaluated 111 MEC, SDC, CEPA, or AdCC cases among 134 patients with high-grade parotid carcinoma.
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- * In a study of 50 platinum-refractory mUC patients, 24% had TLS, but no significant difference in NLR between groups with or without TLS was found.
- * The research showed that lower NLR patients with TLS had longer overall survival and progression-free survival, while these benefits were not seen in higher NLR patients, suggesting that the presence of TLS may correlate with better treatment outcomes in specific patient groups.
Article Synopsis
- - The study explored how a nanoemulsion of astaxanthin, a carotenoid, can protect inner ear hair cells from damage caused by the aminoglycoside antibiotic neomycin, which is known to lead to hearing loss.
- - Researchers tested the effectiveness of astaxanthin against hair cell loss and oxidative stress in cultured mouse cells and through in vivo tests in guinea pigs exposed to noise and the nanoformulation.
- - Results showed that astaxanthin reduced hair cell damage and oxidative radicals, suggesting that this nanoemulsion could be a promising treatment for ototoxicity linked to antibiotic use and provides a method for overcoming drug delivery challenges in the inner ear.
Although the metabolic phenotype within tumors is known to differ significantly from that of the surrounding normal tissue, the importance of this heterogeneity is just becoming widely recognized. Colorectal cancer (CRC) is often classified as the Warburg phenotype, a metabolic type in which the glycolytic system is predominant over oxidative phosphorylation (OXPHOS) in mitochondria for energy production. However, this dichotomy (glycolysis vs.
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- Sebaceous carcinoma (SC) is a rare type of cancer classified into ocular and extraocular forms, with different proposed origins, particularly for extraocular SC.
- This study analyzed clinicopathological features in 11 patients (8 ocular and 3 extraocular), noting the presence of (intraepithelial) lesions and hormonal receptor expressions.
- The research suggests that extraocular SC may arise from sebaceous duct progenitor cells and is the first to show sebaceous differentiation in these cases.
Background: Prognostic factors and survival rate are difficult to determine for adenoid cystic carcinoma(AdCC) of salivary glands.
Aims/objectives: To clarify the clinical characteristics of AdCC and examine factors associated with recurrence and prognosis by histopathological grade classification.
Materials And Methods: Twenty-five patients with AdCC of the parotid gland and 10 patients with AdCC of the submandibular gland were included.
Article Synopsis
- A 64-year-old man from Japan found a hard lump in his armpit, which turned out to be a rare type of breast cancer called a neuroendocrine tumor.
- Doctors removed the tumor and nearby lymph nodes and discovered that most of the tumor was made up of neuroendocrine cells.
- The man received additional treatments including chemotherapy, hormone therapy, and radiation to help fight the cancer.
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- The tumor microenvironment plays a crucial role in cancer progression, with the desmoplastic reaction (DR) around tumor cells being a key factor in colorectal cancer (CRC) prognosis.
- Immature type DR is linked to worse outcomes and higher cancer stages, lymphatic invasion, and lymph node metastasis, but its relationship with tumor deposits (TD) had not been previously explored.
- This study of 443 CRC patients shows a significant association between immature DR and the presence of TD, alongside other aggressive tumor features, highlighting the need for further research into the mechanisms behind immature DR for potential treatment advancements.
Background: Although the SpyGlass Direct Visualization System can be clinically useful for diagnosing indeterminate biliary stricture, it employs SpyBite forceps, which typically obtain only a small amount of tissue and have a low sampling rate. An improved forceps biopsy device for SpyGlass DS has recently been released (SpyBite MAX). The aim of this prospective registration study was to assess the diagnostic yield and efficacy of histological biopsy tissue obtained with SpyBite MAX forceps compared with SpyBite forceps in patients with indeterminate biliary stricture.
View Article and Find Full Text PDFBackground: Glucocorticoids (GCs) are highly effective yet problematic agents against bronchopulmonary dysplasia (BPD). The dimeric trans-activation of GCs induces unfavorable effects, while monomeric trans-repression suppresses inflammation-related genes. Recently, non-steroidal-selective glucocorticoid-receptor agonists and modulators (SEGRAMs) with only the trans-repressive action have been designed.
View Article and Find Full Text PDFObjective: The objective of this study was to evaluate nailfold videocapillaroscopy (NVC) as a useful tool for assessing the disease activity of ANCA-associated vasculitis (AAV).
Methods: This study enrolled 51 patients with AAV and 21 healthy controls. We scored NVC findings semiquantitatively, and compared them between AAV patients and controls.