Publications by authors named "Yoshimune Yamasaki"
Article Synopsis
- Glioma stem cells (GICs) are crucial for the resistance and recurrence of malignant gliomas, and this study investigates their maintenance and differentiation through an integrated proteogenomic approach.
- Researchers found that chondroitin sulfate proteoglycan 4 (CSPG4) and its related enzymes are significantly involved in GIC functionality, with a focus on how their interaction and modification affect GIC behavior.
- The results suggest that the carbohydrate modification on CSPG4 (termed CS-CSPG4) plays an essential role in nurturing GICs and may serve as a novel therapeutic target for treating glioblastoma.
Article Synopsis
- Inclusion Body Myositis (IBM) is a challenging muscle disease with both inflammation and degeneration of muscle fibers, leading to symptoms like swallowing difficulties and balance issues.
- A case study of a female patient with IBM revealed rapid progression of these symptoms, accompanied by macroglossia (enlarged tongue), along with significant findings from muscle and tongue biopsies.
- The patient was diagnosed with IBM and Sjögren's syndrome and received treatment with steroids and immunotherapy, resulting in short-term improvement, suggesting macroglossia could indicate positive response to treatment.
