Publications by authors named "Yoshimitsu Kumamoto"
To investigate the influence of Chlorella (Parachlorella beijerinckii) on the excretion and tissue accumulation of methylmercury (MeHg), we orally administered 5 mg/kg of MeHg chloride (4 mg Hg/kg) to female C57BL/6N mice (aged 10 weeks). The mice were housed in metabolism cages to collect urine and feces for 3 weeks with diets containing 0%, 5%, or 10% P. beijerinckii powder (BP) in a basal diet (CE-2).
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- Chlorella (Parachlorella beyerinckii CK-5) is a type of green algae used as a nutritional supplement, and this study explores its potential to detoxify methylmercury (MeHg) in mice.
- Female mice were divided into two groups and administered MeHg with or without Chlorella powder, followed by collection of urine, feces, and tissue samples to measure mercury levels.
- Results showed that mice given Chlorella excreted significantly more mercury in feces and urine but did not have different blood or organ mercury levels, indicating that Chlorella may promote MeHg excretion without affecting its absorption in the gut.