Effects of repetitive insertion/removal and occlusal load on the retentive force of rest plate-I bar clasps made by selective laser melting.

The objective of this study was to investigate the effects of repetitive removal/insertion and a load equivalent to the occlusal force on the retentive force of rest plate-I bar (RPI) clasps fabricated by selective laser melting (SLM) on powder bed fusion. RPI clasp fabricated by SLM and casting were evaluated to the retentive force by repetitive removal/insertion (SLM-RI and Cast-RI), and the retentive force of RPI clasp by SLM was also evaluated by repetitive removal/insertion under load (SLM-L). SLM-RI group was kept superior retentive force during repetitive removal/insertion than Cast-RI group.

Halo-perfluoroalkoxylation of -difluoroalkenes with short-lived alkali metal perfluoroalkoxides in triglyme.

Alkali metal alkoxides play a pivotal role in nucleophilic alkoxylation reactions, offering pathways for the synthesis of ethers, including the increasingly sought-after trifluoromethyl ethers. However, the synthesis of long-chain perfluoroalkyl ethers remains a substantial challenge in this field. Through the innovative use of triglyme to encapsulate potassium ions, we enhanced the stability of short-lived, longer-chain perfluoroalkoxy anions, thereby facilitating efficient nucleophilic perfluoroalkoxylation reactions.

Effects of repetitive insertion/removal cycles and simulated occlusal loads on retention of denture retainers.

The purpose of this study was to investigate the effects of repetitive insertion/removal cycle tests on denture retainers with simulated occlusal loads on the retentive force and deformation of clasp. Abutment teeth in the form of mandibular secondary premolars and clasp in the form of Akers clasps were prepared. The retentive force of the clasp on the abutment teeth were evaluated before and after undergoing repetitive insertion/removal cycle tests with or without cyclic loading.

Influence of reinforcement bar on accuracy of removable partial denture framework fabricated by casting with a 3D-printed pattern and selective laser sintering.

Purpose: The purpose of this study was to investigate the accuracy of removable partial denture frameworks fabricated by 3D-printed pattern casting (AM-Cast) and selective laser sintering (SLS) under different co nditions with a reinforcement bar.

Methods: A partially edentulous model was scanned with a dental laboratory scanner, and CAD software was used to design the framework. Reinforcement bars (n=0-2) were set on the lingual side of the framework.

Accuracy of Clasps Fabricated with Three Different CAD/CAM Technologies: Casting, Milling, and Selective Laser Sintering.

Purpose: To compare the fabrication accuracy of clasps made using different CAD/CAM technologies.

Materials And Methods: Five clasps were created using three CAD/CAM technologies: casting from a resin pattern using additive manufacturing; computer numerical controlled milling; and selective laser sintering (SLS). Differences between the scan data of the clasps and the CAD data were statistically analyzed.

Accuracy of removable partial denture framework fabricated by casting with a 3D printed pattern and selective laser sintering.

Purpose: The present study aimed to compare the accuracy of removable partial denture (RPD) frameworks fabricated by 3D-printed pattern casting and those fabricated by selective laser sintering (SLS).

Methods: A partially edentulous mandibular model was used for the simulation model. Scanning of the model was performed using a dental scanner.

Resistance of Fetal Guinea Pig Ventricular Myocardium to Hypoxia: Maintained Intracellular ATP Prevents the Opening of ATP-Sensitive Potassium Channels.

The presence and function of the ATP-sensitive potassium channel current (I) were examined in the guinea pig myocardium to clarify the mechanisms for the resistance of the fetal myocardium to hypoxia. Experimental hypoxia markedly reduced the action potential duration and contractile force in isolated ventricular myocardium from the adult, but only moderately in those from the fetus. In isolated ventricular cardiomyocytes, the density of the I activated by cromakalim, as well as their sensitivity to intracellular ATP concentration, were not different between the fetus and adult.

Discovery of novel 5,5-diarylpentadienamides as orally available transient receptor potential vanilloid 1 (TRPV1) antagonists.

We have developed a novel and potent chemical series of 5,5-diphenylpentadienamides for targeting TRPV1 in vitro and in vivo. In this investigation, we examined a variety of replacements for the 5-position of dienamides with the goal of addressing issues related to pharmacokinetics. Our data suggest that substitution with alkoxy groups on the phenyl ring at the 5-position increases their ability to penetrate the blood-brain barrier.

H₂receptor-mediated positive inotropic effect of histamine in neonatal guinea-pig left atria.

The receptor type mediating the positive inotropic effect of histamine was examined in left atria from neonatal guinea pigs. The positive inotropic effect of histamine, as well as its action potential prolonging effect, was antagonized by ranitidine, but not by chlorpheniramine or thiperamide. The positive inotropic effect was enhanced by isobutylmethylxantine.