Guianolactones A and B, Two Rearranged Pentacyclic Limonoids from the Seeds of Carapa guianensis.

Two novel rearranged limonoids, guianolactones A (1) and B (2), were isolated from Carapa guianensis Aubl. (Meliaceae) seeds. The structures of 1 and 2 with their absolute configurations were elucidated in detailed examinations using single-crystal X-ray diffraction analyses and 2D NMR spectra.

Carapanosins A-C from Seeds of Andiroba (Carapa guianensis, Meliaceae) and Their Effects on LPS-Activated NO Production.

Two new phragmalin-type limonoids, Carapanosins A and B ( and ), and a new gedunin-type limonoid, Carapansin C (), together with five known limonoids (-) were isolated from the oil of A (Meliaceae) seeds, a traditional medicine in Brazil and Latin American countries. Their structures were elucidated on the basis of spectroscopic analyses using 1D and 2D NMR techniques and HRFABMS. Compounds - were evaluated for their effects on the production of NO in LPS-activated mouse peritoneal macrophages.