Effect of an intensive antiplaque regimen on microbiome outcomes after nonsurgical periodontal therapy.

Background: It has been well documented that periodontal treatment decreases the levels of certain disease-associated species in subgingival plaque. Few studies, however, investigate to which extent periodontal therapy restores a health-like subgingival community. Here, we conducted a secondary analysis to evaluate microbiome outcomes of nonsurgical periodontal therapy alone or followed by an intensive antiplaque regimen, analyzing microbiome trajectories at the community level with respect to health.

Association of in human saliva with periodontal status and composition of the salivary microbiome including periodontopathogens.

Unlabelled: promotes dental biofilm formation, increases the prevalence of periodontal disease, and is associated with systemic diseases such as colorectal cancer. However, differences in the composition of salivary microbiome among groups based on the abundance of are unclear. Therefore, we analyzed the difference in salivary microbiome among groups based on the abundance of in saliva samples collected from 611 subjects in Japan.

Impact of Local Drug Delivery of Minocycline on the Subgingival Microbiota during Supportive Periodontal Therapy: A Randomized Controlled Pilot Study.

The aim of this study was to examine the effect of adjunct local minocycline administration on the microbiological parameters of subgingival plaque samples in the residual periodontal pockets. Ten chronic periodontitis patients under a supportive periodontal therapy regimen were recruited. After subgingival debridement, either 2% minocycline gel, Periocline™, (Test Group) or a placebo (Control Group) was administered to the selected sites once a week for three weeks.