Decreased expression of KAI1 metastasis suppressor gene is a recurrence predictor in primary pTa and pT1 urothelial bladder carcinoma.

Objective: To examine the expression of the KAI1 metastasis suppressor gene and to evaluate its relationship with tumor recurrence in primary pTa and pT1 urothelial bladder carcinoma.

Methods: Samples were obtained from 87 patients after transurethral resection (TUR). Tumor stage and grade were reviewed in 33 patients with pTa and in 54 patients with pT1, with a mean follow-up time of 47.

Phenylacetate inhibits growth and modulates cell cycle gene expression in renal cancer cell lines.

Background: Phenylacetate (PA), an aromatic fatty acid, is now undergoing evaluation as a potential anticancer reagent. Our previous study showed that PA induces cell growth inhibition in prostate cancer cells. Here, we investigated whether PA is effective against three renal cancer cell lines in vitro.