Publications by authors named "Yoshiki Osaki"
Background And Aims: An efficient cell-culture system for hepatitis B virus (HBV) is indispensable for research on viral characteristics and antiviral reagents. Currently, for the HBV infection assay in cell culture, viruses derived from HBV genome-integrated cell lines of HepG2.2.
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- TP53 gene abnormalities, particularly mutations and deletions, significantly impact the prognosis in acute myeloid leukemia (AML), but most research has focused only on the DNA binding domain of the gene.* -
- In a study of 412 AML cases, TP53 mutations were found in 7.3% of patients, with some identified outside the traditionally examined DNA binding domain, indicating a broader scope of mutation potential.* -
- The presence of TP53 mutations, both in and outside the DNA binding domain, was linked to poorer overall and relapse-free survival, especially in patients aged 70 and younger without FLT3-ITD mutations, highlighting the need for comprehensive TP53 evaluation in AML treatment plans.*