Publications by authors named "Yoshiki Murotani"

Objective: Hounsfield units (HU) measured using computed tomography (CT) have gained considerable attention for the detection of osteoporosis. This study aimed to investigate whether opportunistic CT could predict vertebral fractures in patients with rheumatoid arthritis (RA).

Methods: A total of 233 patients with RA who underwent chest CT were included in this study.

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  • Giant cell tumors of bone (GCTBs) are aggressive tumors characterized by giant and stromal cells, and denosumab is a drug that targets RANKL to inhibit tumor activity.
  • In a study analyzing six GCTB cases, denosumab treatment showed changes in RANKL expression and promoted the differentiation of tumor cells into osteoblasts and osteocytes.
  • The results indicate that denosumab suppresses GCTB activity through the RANK-RANKL pathway, particularly by preventing the formation of osteoclasts.
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  • Anti-citrullinated protein/peptide antibodies (ACPAs) play a key role in rheumatoid arthritis (RA), and this study specifically focused on anti-citrullinated osteopontin (anti-cit-OPN) antibodies in RA pathogenesis.* -
  • In a study of 224 RA patients, around 44% exhibited anti-cit-OPN antibodies, and these antibodies were linked to increased inflammation and more severe arthritis in an animal model.* -
  • The presence of anti-cit-OPN antibodies in RA patients correlated with a lower effectiveness of TNF inhibitors, suggesting their potential as a biomarker for treatment outcomes in RA.*
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The prevalence of preoperative deep vein thrombosis (DVT) has been reported to be relatively high in patients undergoing total hip arthroplasty. We investigated the prevalence of DVT, the association between hip function and preoperative DVT, and the effect of a history of surgery in patients who underwent primary total hip arthroplasty. We retrospectively analyzed the cases of the patients who underwent primary total hip arthroplasty between April 2013 and February 2020 at our institution.

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Juvenile idiopathic arthritis (JIA) can lead to joint deformity and bone destruction, which can cause gait disturbances. To the best of our knowledge, there are no case reports with over 10 years of follow-up on quadruple joint arthroplasties (QJA) for bilateral hip and knee ankylosis associated with JIA. We present the case of a 29-year-old woman with JIA.

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  • Hypoxia in inflammatory conditions, like rheumatoid arthritis (RA), promotes bone resorption by enhancing the formation of osteoclasts, but the exact mechanisms linking hypoxia to osteoclastogenesis are not well understood.
  • This study investigates the role of the protein lysine-specific demethylase 1 (LSD1) in connecting inflammatory osteoclastogenesis and bone loss using both cell studies and experimental mouse models of arthritis.
  • The research finds that LSD1 expression is increased in RA patients and is crucial for osteoclast differentiation, revealing potential genetic pathways that link hypoxia to the accelerated bone erosion seen in inflammatory arthritis.
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Background: Socket fixation with bone grafting for dysplastic hips is technically demanding, and inadequate coverage of the socket may cause poor results in patients with severely dysplastic hips. An accurate technique to form a bone graft to fit into the defect is necessary. We aim to introduce the simple method of bone grafting, "inverted reamer technique" in cemented total hip arthroplasty (cTHA).

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Background: In our institute, all elderly patients with displaced femoral neck fracture were treated with cemented bipolar hemiarthroplasty (BHA) using the modified Dall approach. To our knowledge, there are no reports on the knot position of the greater trochanter reattachment. The aim of this study was to determine influence of two knot positions (anterior or posterior) on the complications of the greater trochanter.

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Background: The direct lateral modified Dall's approach for total hip arthroplasty (THA) provides an excellent vision of the hip joint by osteotomising the greater trochanter (GT). A robust method for the reattachment of osteotomised fragments is essential to prevent complications around the GT. Ultra-high molecular weight polyethylene cables are reported to be useful for reattachment; but the optimal suture method of these cables is unknown.

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Background: Dislocation following total hip arthroplasty is mainly caused by malposition. However, the coexistence of neuromuscular disorders is also considered a risk for dislocation due to excessive hip joint laxity. To minimize risk of dislocation, preoperative planning using combined anteversion has been widely used.

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