Publications by authors named "Yoshikawa J"

In this study, a draft genome sequence of kiy1 isolated from unpasteurized honey in Japan was analyzed. This strain was reported to be a promising arabitol-producing strain, and this report contributes to a better understanding of arabitol production in yeasts.

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Introduction: Patients with type 2 diabetes (T2D) undergoing dialysis exhibit a higher mortality rate compared with those with other conditions, primarily due to vascular complications including coronary artery disease, heart failure and stroke. Sodium-glucose cotransporter 2 (SGLT2) inhibitors, a type of drug for T2D, have reportedly decreased cardiovascular and renal events in patients with heart failure and chronic kidney disease, irrespective of diabetes presence. Nevertheless, the evidence supporting the use of SGLT2 inhibitors in patients undergoing dialysis has been limited.

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Article Synopsis
  • Tubulointerstitial nephritis (TIN) is an inflammation of the kidney interstitium, often involving T cells, with a newer classification called IgMPC-TIN characterized by IgM-positive plasma cell infiltration.
  • A 70-year-old woman with Fanconi syndrome and renal tubular acidosis was diagnosed with IgMPC-TIN, showing improvement in renal function after corticosteroid treatment, but ultimately died from liver failure and complications.
  • The autopsy findings indicated liver issues such as nodular regenerative hyperplasia, suggesting that IgMPC-TIN can also manifest in liver diseases, expanding its known associations beyond just primary biliary cholangitis (PBC).
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  • Cloud optical quantum computing benefits from a fiber-based system, which avoids the need for spatial alignment but faces challenges like phase drifts and polarization fluctuations due to environmental conditions.* -
  • The study presents a successful measurement of squeezed light using a fiber system over 24 hours, utilizing stabilization techniques to reduce instabilities and an integrated controller for automatic alignment.* -
  • The results show consistent squeezing levels of -4.42 dB with minimal variation, indicating that this technology could enable the development of complex optical setups for long-term operation in quantum computing cloud services.*
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  • Rice vinegar in Japan, specifically Honcho, was traditionally lactic fermented during the Edo period, contrasting with the acetic fermentation commonly used today.
  • Analysis of Honcho revealed it has a lower level of acetic acid, higher free amino acids, and a stronger umami taste compared to modern rice vinegar, Kurozu.
  • The study suggests that Honcho served as a unique acidic seasoning in Edo period cuisine, enhancing dishes with umami rather than just sourness.
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d-Arabitol, an alternative sweetener to sugar, has low calorie content, high sweetness, low glycemic index, and insulin resistance-improving ability. In this study, d-arabitol-producing yeast strains were isolated from various commercial types of miso, and strain Gz-5 was selected among these strains. Phylogenetic tree analysis of the internal transcribed spacer sequence revealed that strain Gz-5 was distinct from Zygosaccharomyces rouxii, a major fermenting yeast of miso.

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Arabitol is gaining attention in the food industry as an alternative sweetener owing to its low-caloric and non-cariogenic characteristics. The yeast strain kiy1 was newly isolated from unpasteurized honey for arabitol production. Based on internal transcribed spacer sequence analysis, the isolated strain was identified as Zygosaccharomyces siamensis.

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Measurement-based quantum computation with optical time-domain multiplexing is a promising method to realize a quantum computer from the viewpoint of scalability. Fault tolerance and universality are also realizable by preparing appropriate resource quantum states and electro-optical feedforward that is altered based on measurement results. While linear feedforward has been realized and become a common experimental technique, nonlinear feedforward was unrealized until now.

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  • Optical quantum information processing needs efficient interference of quantum light, but using optical fibers can reduce this interference due to polarization issues.
  • * The proposed method optimizes interference visibility by controlling polarizations along two circular paths on the Poincaré sphere, using fiber stretchers as polarization controllers.
  • * Experimental results show this method maintains over 99.9% visibility for three hours with only 0.02 dB (0.5%) optical loss, enhancing the feasibility of fiber systems for practical optical quantum computers.*
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Background: Zalaria sp. Him3 was reported as a novel fructooligosaccharides (FOS) producing yeast. However, Zalaria spp.

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Controlling the temporal waveform of light is the key to a versatile light source in classical and quantum electronics. Although pulse shaping of classical light is mature and has been used in various fields, more advanced applications would be realized by a light source that generates arbitrary quantum light with arbitrary temporal waveforms. We call such a device a quantum arbitrary waveform generator (Q-AWG).

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Telecommunication wavelength with well-developed optical communication technologies and low losses in the waveguide are advantageous for quantum applications. However, an experimental generation of non-classical states called non-Gaussian states at the telecommunication wavelength is still underdeveloped. Here, we generate highly-pure-single-photon states, one of the most primitive non-Gaussian states, by using a heralding scheme with an optical parametric oscillator and a superconducting nano-strip photon detector.

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Purpose: Anatomic isolated liver segmentectomy 8 (ILSeg8) for malignancies remains technically challenging. The feasibility, safety, and oncologic validity of laparoscopic ILSeg8 are undefined, and thus were evaluated in comparison with the open approach.

Methods: This study enrolled 35 open and 29 laparoscopic ILSeg8 cases of hepatocellular carcinoma (n = 47), metastatic liver tumors (n = 16), and intrahepatic cholangiocarcinoma (n = 1) at our institution.

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Article Synopsis
  • - Non-Gaussian states are crucial for advancing optical quantum technologies, and the Optical Quantum State Synthesizer (OQSS) is a promising method for their preparation using Gaussian inputs and linear optics.
  • - A major challenge is the complexity of simulating the state preparation on classical computers, making it tough to generate essential non-Gaussian states for quantum processing.
  • - The authors propose a backcasting approach to simplify the OQSS design, simulating it layer by layer from the final output back to the beginning, which can also limit the photon detection requirements to a maximum of 2 photons.
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Continuous-wave (CW) squeezed light is used in the generation of various optical quantum states, and thus is a fundamental resource of fault-tolerant universal quantum computation using optical continuous variables. To realize a practical quantum computer, a waveguide optical parametric amplifier (OPA) is an attractive CW squeezed light source in terms of its THz-order bandwidth and suitability for modularization. The usages of a waveguide OPA in quantum applications thus far, however, are limited due to the difficulty of the generation of the squeezed light with a high purity.

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Background: Autoimmune tubulointerstitial nephritis (TIN) is characterized by immune-mediated tubular injury and requires immunosuppressive therapy. However, diagnosing TIN and assessing therapeutic response are challenging for clinicians due to the lack of useful biomarkers. Pathologically, CD4 T cells infiltrate to renal tubulointerstitium, and soluble interleukin-2 receptor (sIL-2R) has been widely known as a serological marker of activated T cell.

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Previously, we found that a multicopper oxidase (IOX) produced by Iodidimonas sp. Q-1, an iodide (I)-oxidizing marine bacterium, exhibited significant decolorization activity toward various anionic dyes. In this study, the potential capacity of IOX for decolorization of cationic dyes such as malachite green (MG), crystal violet (CV), and methylene blue (MB) was determined.

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Background: Chronic high Epstein-Barr virus loads (CHEBV) are commonly observed in pediatric liver transplant patients. However, it is unclear how CHEBV impacts the liver graft. The aim of this study was to clarify the clinical and pathological impacts of CHEBV on the liver graft.

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Aims: This study aimed at obtaining a novel fructooligosaccharides (FOS)-producing yeast, which was different from conventional FOS producers, Aureobasidium spp.

Methods And Results: Strain Him3 was newly isolated from a Japanese dried sweet potato as a FOS producer. The strain exhibited yeast-like cells and melanization on the potato dextrose agar medium, and formed very weak pseudomycelia on the yeast extract polypeptone dextrose agar medium.

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Background: Minimally invasive pancreaticoduodenectomy (MIPD), including laparoscopic pancreaticoduodenectomy (LPD) and robotic pancreaticoduodenectomy (RPD), is technically demanding because of pancreaticojejunostomy (PJ). Postoperative pancreatic fistula (POPF) is the most serious complication of MIPD and open pancreaticoduodenectomy (OPD). Contrary to expectations, conventional PJ in MIPD did not improve POPF rate and length of hospital stay.

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Article Synopsis
  • Optical quantum computation needs carefully created multimode photonic quantum states to function effectively.
  • The study shows the successful phase locking of two all-optical quantum memories, which allows for the precise timing of releasing two-mode entangled single-photon states.
  • The released states maintain their entanglement and nonclassical properties even with release-time differences of up to 400 nanoseconds, validated through advanced measurement techniques.
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  • Acute obstruction of the hepatic vein (HV) or portal vein (PV) during liver surgery is a serious issue that requires prompt action, as traditional surgical solutions can be complex and often unsuccessful.
  • The paper presents two cases where patients faced acute, surgically uncorrectable HV or PV obstructions during liver surgeries, which traditional methods did not resolve.
  • Both patients were successfully treated with emergency endovascular stenting by interventional radiology, which quickly restored blood flow to the affected veins.
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Tumor lysis syndrome (TLS) is an oncologic emergency caused by release of intracellular tumor components due to massive tumor lysis and is rare in patients with hepatocellular carcinoma (HCC). We describe a case of TLS with rupture of HCC induced by lenvatinib in a patient with advanced HCC. A 72-year-old man who presented with right upper abdominal pain was diagnosed as having advanced HCC with a high tumor burden by contrast-enhanced computed tomography and percutaneous hepatic tumor biopsy.

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Background: In an increasing number of patients undergoing radical surgery for perihilar cholangiocarcinoma [1-3], the intrahepatic bile duct is conventionally transected after the vessels to be preserved or reconstructed are confirmed [3,4]. In patients with extremely advanced perihilar cholangiocarcinoma having massive vascular involvement, it is sometimes difficult to confirm the vessels for reconstruction because of restricted working space and/or anatomical variants, even after liver parenchymal dissection [4]. When the vessels cannot be confirmed, the tumor is usually unresectable [4].

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