Publications by authors named "Yoshikatsu Hosoda"
Article Synopsis
- The study aimed to assess the effectiveness of measuring tear meniscus height (TMH) using anterior segment optical coherence tomography (AS-OCT) for diagnosing lacrimal passage disorder (LPD) in cataract surgery patients.
- Out of 66 patients, only 12 (9.4%) had LPD, and those with LPD had a significantly higher average TMH compared to those without the disorder.
- The optimal TMH cutoff value for detecting LPD was found to be 401.0 μm, demonstrating a sensitivity of 58.3% and specificity of 83.0%, indicating AS-OCT's usefulness in preoperative assessments.
Purpose: To evaluate the association of tear meniscus height (TMH) with clinical outcomes of patients who underwent endonasal dacryocystorhinostomy.
Methods: We recruited 304 patients from two institutes. The TMH was measured using anterior segment optical coherence tomography before surgery.
Article Synopsis
- The study investigates the progression of pachychoroid pigment epitheliopathy (PPE) in patients with unilateral central serous chorioretinopathy (CSC) over a period of 6 years.
- Out of 165 patients analyzed, 89.7% showed signs of PPE in their non-CSC eye, with about 16.8% developing CSC during the follow-up period, while the non-PPE eyes did not.
- Key findings indicated that choroidal vascular hyperpermeability and subfoveal choroidal thickness were significant factors associated with the onset of CSC, though genetic factors examined did not show a substantial link.
Purpose: To investigate the 2-year effectiveness of reduced-fluence photodynamic therapy (rf-PDT) for chronic central serous chorioretinopathy (cCSC).
Design: Retrospective cohort study.
Participants: A total of 223 consecutive patients with newly diagnosed cCSC with active serous retinal detachment (SRD) were included from May 2007 to June 2017 and followed up for at least 2 years.
Purpose: To evaluate the association between central serous chorioretinopathy (CSC) susceptibility genes and choroidal parameters in a large Japanese cohort.
Study Design: Retrospective cohort study.
Methods: Of the 9850 individuals in the Nagahama study whose second visit was between 2013 and 2016, those with optical coherence tomography (OCT) images with enhanced depth imaging (EDI), axial length, and genome-wide single nucleotide polymorphism (SNP) genotyping data were included.
Coughing-induced retinal pigment epithelial tear after trabeculectomy combined with pars plana vitrectomy.
Am J Ophthalmol Case Rep
September 2022
Purpose: To report a case of retinal pigment epithelial (RPE) tear after trabeculectomy combined with pars plana vitrectomy (PPV).
Observations: A 65-year-old man with neovascular glaucoma due to proliferative diabetic retinopathy presented with visual impairment and elevated intraocular pressure (IOP) in the right eye and underwent trabeculectomy combined with PPV. Three weeks after surgery, the best-corrected visual acuity (logarithm of minimal angle of resolution) improved from 3.
Article Synopsis
- The study aimed to find genes that make individuals more prone to developing macular neovascularization (MNV) in patients with central serous chorioretinopathy (CSC).
- Researchers conducted a genome-wide survival analysis using two patient cohorts and applied statistical methods to identify significant genetic markers.
- Key findings showed that the ARMS2 gene and three other previously reported genes were linked with MNV susceptibility, indicating potential pathways and genetic influences associated with the condition.
Purpose: To report fundamental epidemiologic data for choroidal parameters such as choroidal thickness and index of choroidal vascularity in Japanese individuals and to evaluate their correlations with age, sex, systemic parameters, and other ocular parameters.
Design: Population-based cohort study.
Participants: A total of 9850 individuals participated in the first follow-up of the Nagahama Prospective Cohort for Comprehensive Human Bioscience (the Nagahama Study) conducted between 2013 and 2016.
Purpose: To evaluate the association between daily coffee consumption and intraocular pressure (IOP) in healthy persons without glaucoma and the association between daily coffee consumption and history of glaucoma.
Design: Cross-sectional study.
Participants: A total of 9850 individuals participated in the first follow-up of the Nagahama Prospective Cohort for Comprehensive Human Bioscience (the Nagahama Study) conducted between 2013 and 2016.
Purpose: To survey the prevalence and clinical and genetic characteristics of pachydrusen in eyes with central serous chorioretinopathy (CSC) and those of Japanese individuals in the general population.
Design: Prospective, observational cohort study.
Participants: One thousand thirty-seven Japanese patients were included in this study.
Unsupervised machine learning has received increased attention in clinical research because it allows researchers to identify novel and objective viewpoints for diseases with complex clinical characteristics. In this study, we applied a deep phenotyping method to classify Japanese patients with age-related macular degeneration (AMD), the leading cause of blindness in developed countries, showing high phenotypic heterogeneity. By applying unsupervised deep phenotype clustering, patients with AMD were classified into two groups.
View Article and Find Full Text PDFGenetic studies have investigated the pathogenesis of age-related macular degeneration (AMD). The pachychoroid concept has recently garnered attention as a possible explanation for AMD pathogenesis; the genetic characteristics of pachychoroid diseases have also been elucidated. In this review, we summarize previously reported genetic characteristics of AMD and pachychoroid diseases, and analyze these data to understand the pathogenesis of AMD and pachychoroid diseases.
View Article and Find Full Text PDFPurpose: To describe the distribution of ocular biometry and refraction in Japanese adults.
Design: Cross-sectional analysis of a prospective cohort study.
Participants: A total of 9850 individuals participated in the first follow-up of the Nagahama Prospective Cohort for Comprehensive Human Bioscience (the Nagahama Study) conducted between 2013 and 2016.
Keratoconus is a common ocular disorder that causes progressive corneal thinning and is the leading indication for corneal transplantation. Central corneal thickness (CCT) is a highly heritable characteristic that is associated with keratoconus. In this two-stage genome-wide association study (GWAS) of CCT, we identified a locus for CCT, namely STON2 rs2371597 (P = 2.
View Article and Find Full Text PDFThe emergence of pachychoroid disease is changing the concept of age-related macular degeneration (AMD). The concept of pachychoroid diseases was developed through clinical observation of multimodal images of eyes with AMD and central serous chorioretinopathy; however, recent genetic studies have provided a proof of concept for pachychoroid spectrum disease, which should be differentiated from drusen-driven AMD. The genetic confirmation of pachychoroid concept further provides novel viewpoints to decode previously reported findings, which facilitates an understanding of the true nature of pachychoroid diseases and AMD.
View Article and Find Full Text PDFPurpose: To identify novel susceptibility loci for high myopia.
Design: Genome-wide association study (GWAS) followed by replication and meta-analysis.
Participants: A total of 14 096 samples from East and Southeast Asian populations (2549 patients with high myopia and 11 547 healthy controls).
Article Synopsis
- Corneal curvature is a key genetic factor related to myopia, which can lead to severe visual impairment and blindness globally.
- Researchers conducted a large study involving over 132,000 individuals from Caucasian and Asian backgrounds to find genetic loci affecting corneal curvature.
- The study identified 47 genetic locations, including 26 new ones, that influence corneal curvature and eye elongation, shedding light on how these genes might affect myopia risk and eye development.
Objective: Age-related macular degeneration (ARMD) is a leading cause of visual impairment. Intravitreal injections of anti-vascular endothelial growth factor (VEGF) are the standard treatment for wet ARMD. There is however, variability in patient responses, suggesting patient-specific factors influencing drug efficacy.
View Article and Find Full Text PDFArticle Synopsis
- The pachychoroid concept has reshaped the understanding of age-related macular degeneration (AMD), revealing a connection with central serous chorioretinopathy (CSC).
- A large genome-wide association study identified two new genetic loci linked to CSC susceptibility in a diverse sample of 1546 CSC patients and 13,029 controls.
- The findings highlight that certain risk alleles, specifically at rs13278062, are associated with both CSC and AMD, enhancing the understanding of the genetic factors involved in these diseases.
Purpose: To evaluate the roles of known myopia-associated genetic variants for development of myopic macular degeneration (MMD) in individuals with high myopia (HM), using case-control studies from the Consortium of Refractive Error and Myopia (CREAM).
Methods: A candidate gene approach tested 50 myopia-associated loci for association with HM and MMD, using meta-analyses of case-control studies comprising subjects of European and Asian ancestry aged 30 to 80 years from 10 studies. Fifty loci with the strongest associations with myopia were chosen from a previous published GWAS study.
Predictive Genes for the Prognosis of Central Serous Chorioretinopathy.
Ophthalmol Retina
November 2019
Purpose: To investigate potential genetic prognostic factors associated with spontaneous resolution of serous retinal detachment (SRD) and development of choroidal neovascularization (CNV) in central serous chorioretinopathy (CSC).
Design: Retrospective analysis of a case series.
Participants: One hundred ninety-six eyes from 196 patients with active CSC.
Purpose: To explore novel prognostic factors associated with visual function and number of anti-vascular endothelial growth factor (VEGF) treatments in eyes with active myopic choroidal neovascularization (mCNV) using OCT angiography (OCTA).
Design: Prospective case series.
Participants: Twenty-eight treatment-naïve eyes with active mCNV from 27 consecutive patients (mean age, 64.
Central serous chorioretinopathy (CSC) is a common disease affecting younger people and may lead to vision loss. CSC shares phenotypic overlap with age-related macular degeneration (AMD). As recent studies have revealed a characteristic increase of choroidal thickness in CSC, we conducted a genome-wide association study on choroidal thickness in 3,418 individuals followed by TaqMan assays in 2,692 subjects, and we identified two susceptibility loci: rs800292, an established AMD susceptibility polymorphism, and rs3793217 ( = 2.
View Article and Find Full Text PDFThe incidence of high myopia is increasing worldwide with myopic maculopathy, a complication of myopia, often progressing to blindness. Our two-stage genome-wide association study of myopic maculopathy identifies a susceptibility locus at rs11873439 in an intron of CCDC102B (P = 1.77 × 10 and P = 1.
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