Publications by authors named "Yoshikane Yamauchi"

Background: Several methods can be used to intraoperatively identify pulmonary lesion using radiation technology. However, little is known about patient radiation exposure during chest surgery. We aimed to measure patients' radiation exposure from cone-beam computed tomography (CBCT) used in a hybrid operating room.

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Background/objectives: The efficacy of lung metastasectomy in patients with urothelial carcinoma remains inconclusive, as there is only limited evidence from small studies. In this study, we aimed to assess the prognostic outcomes of excising pulmonary metastases from urothelial carcinoma.

Methods: In this study, we utilized data from the Metastatic Lung Tumor Study Group of Japan database, a multi-institutional prospective database of pulmonary metastasectomies.

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Article Synopsis
  • - The study developed a novel method for detecting circulating tumor cells (CTCs) and analyzing EGFR mutations specifically in lung cancer patients, using a new immunocytology platform.
  • - A pilot study with 33 patients revealed that CTC levels were significantly higher in pulmonary blood samples compared to peripheral blood, and the genetic analysis of CTCs revealed several EGFR mutations that were often consistent with mutations found in lung tissue.
  • - The findings suggest that this new CTC detection method could serve as a useful liquid biopsy tool for monitoring lung cancer in clinical settings, although it showed some limitations in mutation sensitivity.
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Diaphragmatic eventration causes respiratory distress with the development of severe diaphragmatic compression of lung volume. While non-surgical treatment, such as physical therapy and pulmonary rehabilitation, is adequate for mild cases, surgical intervention is critical for severe diaphragmatic eventration. A 45-year-old man with respiratory fatigue was diagnosed with left diaphragmatic eventration and underwent surgery with diaphragmatic plication with double-row stapling under a video-assisted approach.

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A 61-year-old woman was referred for further evaluation of an intracystic nodule in her left upper lung. Computed tomography( CT) showed a 15 mm nodule in a pulmonary cyst adjacent to aortic arch and mediastinum. Fluorodeoxyglucose-positron emission tomography (FDG-PET)-CT showed little uptake of FDG in the lesion.

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Article Synopsis
  • The study investigates the best timing and criteria for treating postoperative air leaks after lung surgery, as practices vary across hospitals.
  • Using data from a 2019 multicenter study, researchers identified 420 patients with air leaks and compared those who received treatment to those who were only monitored.
  • Key findings showed that factors like low body mass index, type of lung surgery, use of fibrin glue, and the severity of air leaks on the first postoperative day can predict the need for intervention, and that a significant number of air leaks resolved spontaneously within a week.
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Background: Secondary pneumothorax, which occurs most commonly in the elderly, is caused by underlying diseases. Cardiac dysfunction and other organ inefficiencies may render surgical repair impossible. Such non-operative and poor-risk cases are targets for pleurodesis, which involves the instillation of chemicals or irritants to the thoracic cavity through injection, bronchoscopic bronchial occlusion, or other procedures.

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Article Synopsis
  • - The study investigates the potential of immunotherapy for patients with advanced non-small cell lung cancer (NSCLC) and distant metastases, aiming to identify prognostic factors and develop a survival prognosis model.
  • - Researchers analyzed data from 100 NSCLC patients treated with immune checkpoint inhibitors between 2018 and 2021, monitoring survival outcomes over nearly three years to establish significant prognostic indicators.
  • - Key factors influencing overall survival included ECOG performance status, BMI, age-adjusted comorbidity index, lactate dehydrogenase levels, and absolute neutrophil count; a predictive model with strong accuracy (C-index of 0.81) was created and validated.
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Purpose: A prolonged air leak (PAL) is one of the common postoperative complications of pulmonary resection. The aim of this study was to evaluate the efficacy and safety of pleurodesis with sterile talc or OK-432 for postoperative air leak.

Methods: Patients with postoperative air leak who received chemical pleurodesis using sterile talc or OK-432 were retrospectively identified from medical records data.

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•Endometrial stromal sarcoma is the second most common type of uterine sarcoma.•Endometrial stromal sarcoma has undergone modifications since its proposal.•This case highlights the importance of accurately diagnosing endometrial stromal sarcoma.

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Article Synopsis
  • A rare anatomical abnormality known as systemic arterial blood supply to a normal lung can lead to pulmonary hypertension, necessitating surgical intervention.* -
  • The report details two cases: one involved a woman in her 50s who underwent a left lower lobectomy with embolization support, and another was a man in his 40s who had a left partial resection with advanced imaging techniques.* -
  • The study emphasizes the safety and effectiveness of combining interventional radiology with thoracoscopic surgery and cone-beam CT imaging to treat this unusual condition.*
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To clarify the clinical impact and to identify prognostic predictors of surgical intervention for pulmonary metastasis from esophageal cancer, a registry database analysis was performed. From January 2000 to March 2020, patients who underwent resection of pulmonary metastases from primary esophageal cancer at 18 institutions were registered in a database developed by the Metastatic Lung Tumor Study Group of Japan. An amount of 109 cases were reviewed and examined for the prognostic factors for pulmonary metastasectomy of metastases from esophageal cancer.

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Article Synopsis
  • Pulmonary capillary hemangiomatosis (PCH) is a rare lung disease marked by abnormal capillary growth in various lung structures, with no known cause.
  • A 38-year-old woman was mistakenly diagnosed with lung carcinoma due to a small nodule, but subsequent surgery revealed that the thickened lung tissue was actually PCH, not cancer.
  • The case highlights the need for more research on PCH, as there are only a few documented instances of solitary PCH lesions.
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Purpose: Metastatic head and neck squamous cell carcinoma (HNSCC) is relatively poor; however, depending on the selected cases, pulmonary metastasectomy can be a practical therapeutic option. This study aimed to identify the outcomes of complete metastasectomy based on each primary site and to investigate unfavorable prognostic factors.

Patients And Methods: We used the database from the Metastatic Lung Tumour Study Group of Japan.

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Article Synopsis
  • The study analyzed records of 12,897 lung cancer patients who had lobectomies, focusing on the risk of tumor recurrence after surgery.
  • The hazard function for recurrence peaked around 9 months post-surgery, with higher risks for intrathoracic recurrences than extrathoracic ones.
  • The findings suggest that understanding these recurrence patterns can help tailor postoperative surveillance strategies based on tumor stage and risk factors.
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Background: The efficacy of surgery in combination of chemotherapy for stage IIIA small cell lung cancer (IIIA-SCLC) is controversial. The aim of the present study was to analyze the efficacy of surgery combined with chemotherapy, especially in the setting of neoadjuvant chemotherapy (NAC) followed by surgery for IIIA-SCLC.

Methods: Between 2004 and 2015, we reviewed 2,199 chemotherapy-treated stage IIIA (N1/2) SCLC cases in the Surveillance, Epidemiology, and End Results (SEER) database, and 32 NAC + intentional radical resection-treated, centrally-located IIIA-SCLC cases at Shanghai Pulmonary Hospital (SPH).

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Background: Limited efficacy and poor prognosis are common in patients with metastatic non-small cell lung cancer (NSCLC). An accurate and useful nomogram helps the clinician predict the prognosis of the patients. However, there has been no previous report on the nomogram specially for predicting the overall survival (OS) of metastatic NSCLC patients.

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Background: Intraoperative identification of small pulmonary nodules has been an important technical issue. We aimed to develop a new localization method which is much safer and simple procedure compared with conventional methods.

Methods: This was a retrospective study including patients with resected peripheral pulmonary nodules between November 2017 and April 2021 at Teikyo University School of Medicine, and Saitama Cardiovascular and Respiratory Center.

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Purpose: Intraoperative complications, especially unexpected bleeding, are of great concern in the safety of thoracoscopic surgery. We investigated the hemostatic efficacy and safety of positive intrapleural pressure (PIP) with carbon dioxide insufflation by assessing the amount of blood loss in a pulmonary arterial hemorrhage model.

Methods: An ex vivo experimental model of saline flow into a swine vessel was created in a container simulating a chest cavity.

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Liquid biopsy has been adapted as a diagnostic test for mutations in patients with advanced or metastatic non-small cell lung cancer (NSCLC). Loop-mediated isothermal amplification (LAMP) has been widely used for the rapid detection of pathogens through DNA amplification. This study investigated the efficacy of an -LAMP assay using plasma samples of patients with resected NSCLC tumors.

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Objectives: For the technical management of tracheal anastomosis, developing new and simple methods is required to relieve anastomotic tension. This study aimed to investigate whether basic fibroblast growth factor (bFGF) only once injected immediately before anastomosis promotes cartilage regeneration at the tracheal anastomosis and whether the regenerated cartilage has the effect of reinforcing the anastomosis in a rabbit model.

Methods: New Zealand white rabbits were anaesthetized, and the cervical trachea was exposed through a cervical midline incision, followed by resection of the 10th tracheal cartilage.

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