Publications by authors named "Yoshihito Tsuzaki"
Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3.
Biochem Biophys Res Commun
November 2015
Article Synopsis
- - Mutations in genes like WNK1, WNK4, KLHL3, and Cullin3 are linked to pseudohypoaldosteronism type II, a hereditary high blood pressure condition, where WNK helps increase sodium reabsorption in the kidneys.
- - Researchers found that the protein KLHL3 can be phosphorylated at a specific site (S433) by enzymes Akt and PKA, which are activated by insulin and vasopressin, leading to impaired binding to WNK4, thus affecting its degradation.
- - The study showed that when KLHL3 is phosphorylated by PKA, it inhibits the degradation of WNK4, suggesting a novel mechanism for how insulin and vasop
A 45-year-old man complaining of cough, dyspnea, and difficulty in swallowing was referred to our hospital. Chest CT scan showed a mediastinal mass compressing the trachea. He was diagnosed with poorly differentiated lung carcinoma by percutaneous needle biopsy.
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