Publications by authors named "Yoshihisa Hori"
Background: Immunosuppression is effective in treating a number of diseases, but adverse effects such as bone marrow suppression, infection, and oncogenesis are of concern. Methotrexate is a key immunosuppressant used to treat rheumatoid arthritis. Although it is effective for many patients, various side effects have been reported, one of the most serious being methotrexate-related lymphoproliferative disorder.
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- - Nephrotoxicity from antimicrobial and anticancer drugs is a significant concern, particularly with drugs like vancomycin and cisplatin, which may cause kidney damage, while megalin facilitates this toxicity by mediating drug uptake in kidney cells.
- - Cilastatin has been shown to reduce the renal damage caused by various drugs by inhibiting megalin’s ability to bind to them, thus protecting kidney cells from injury while not affecting the drugs' effectiveness against infections or cancer.
- - Research demonstrated that cilastatin can effectively mitigate nephrotoxicity from gentamicin, colistin, vancomycin, and cisplatin in specific animal models, suggesting its potential use as a protective agent in