Publications by authors named "Yoshihisa Akiomi"
Blood pressure (BP) variability (BPV) is associated with an increased risk of cardiovascular events, independent of absolute BP values. However, the predictive significance of very short-term BPV, occurring within seconds or minutes, in patients with ischemic heart disease (IHD) has yet to be established. This prospective study involved 206 consecutive hospitalized patients with IHD (mean age 67.
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- Cardiovascular risk factors may increase the risk of developing cancer, but the link between atherosclerosis and future cancer risk is not well understood.
- In a study involving 1,057 patients with coronary artery disease, those with a high cardio-ankle vascular index (CAVI ≥8.82) were older and had more health issues compared to those with a low CAVI.
- The high CAVI group had a significantly greater incidence of new cancers, particularly lung cancer, suggesting that a higher CAVI is an independent predictor of future cancer in these patients.*
Background: Exercise intolerance in heart failure arises from multifactorial pathophysiological mechanisms. Hepatokines, liver-synthesized molecules, regulate systemic metabolisms in peripheral tissues. We previously identified the hepatokine fetuin-A as being linked to liver hypoperfusion in heart failure.
View Article and Find Full Text PDFMalnutrition is classified into marasmus and kwashiorkor in children. However, the clinical significance of these aspects is unclear in adult patients with heart failure (HF). We divided 2308 adult patients with HF into four groups according to marasmus type (body mass index < 18.
View Article and Find Full Text PDFHeart failure is hemodynamically characterized as congestion and/or end-organ hypoperfusion, and is associated with increased morbidity and mortality. Underlying pathophysiology, such as neuro-hormonal activation, exacerbates heart failure and leads to functional deterioration of other organs. We have been conducting clinical research to study the pathophysiology of heart failure and discover prognostic factors.
View Article and Find Full Text PDFAims: The bicarbonate (HCO ) buffer system is crucial for maintaining acid-base homeostasis and blood pH. Recent studies showed that elevated serum HCO levels serve as an indicator of the beneficial effects of acetazolamide in improving decongestion in acute heart failure. In this study, we sought to clarify the clinical relevance and prognostic impact of HCO in chronic heart failure (CHF).
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- The study investigates the role of neutrophil extracellular traps (NETs) in patients with dilated cardiomyopathy (DCM) and heart failure, revealing that NET levels are elevated in DCM patients compared to controls without heart failure.
- Results indicate a strong negative connection between the amount of NETs and left ventricular ejection fraction, impacting heart function and predicting higher risks of adverse cardiac events.
- Experimental findings suggest that NETs impair cardiomyocyte mitochondrial function, and when the enzyme PAD4 is genetically removed, heart function remains intact, indicating its potential as a target for therapeutic strategies.
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- * Researchers used a rat model to find increased CTHRC1 in the right ventricle associated with fibrosis, and measured plasma levels of CTHRC1 in human patients with different types of pulmonary hypertension compared to controls.
- * Findings show that higher plasma CTHRC1 levels correlate with worse right ventricular function, and levels decrease after balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension, indicating CTHRC1's potential as both a biomarker and a measure of treatment effectiveness.
We aimed to evaluate the prognostic value of left ventricular global longitudinal strain (LVGLS) and left atrial strain (LAS) obtained from magnetic resonance imaging (MRI) feature tracking in patients with heart failure with preserved ejection fraction (HFpEF). We retrospectively enrolled consecutive patients with HFpEF admitted to our hospital who underwent cardiac MRI. LVGLS and LAS were obtained from cine MRI by feature tracking.
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- High levels of calcium-phosphorus (Ca-P) product are linked to coronary calcification and increased mortality risk in chronic hemodialysis patients, and this study focuses on its significance in heart failure (HF) and chronic kidney disease (CKD).
- A study of 793 patients with decompensated HF and CKD split participants into high (Ca-P > 28) and low (Ca-P ≤ 28) groups to assess baseline characteristics and outcomes post-discharge.
- Results showed that patients in the low Ca-P group had higher rates of all-cause mortality and worsening HF, with lower Ca-P product emerging as an independent predictor of negative prognosis (P = 0.031).
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- Paravalvular leakage (PVL) is a complication that can occur after transcatheter aortic valve implantation (TAVI), negatively affecting patient outcomes.
- A study assessed the relationship between preoperative aortic valve calcium volume (Ca-Vol) and the occurrence of PVL in 59 patients who underwent TAVI, finding higher Ca-Vol in those with PVL.
- The research indicated that total and specific cusp Ca-Vols were significant predictors of PVL, with specific cut-off values established for predicting the risk of leakage post-surgery.
Aims: We aimed to elucidate the association between malnutrition and the occurrence of bleeding events in patients with heart failure.
Methods And Results: We evaluated the nutritional status of patients with heart failure [n = 2044, median (inter-quartile range) age 69.0 (59.
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- Living alone is linked to higher long-term cardiac mortality in patients with chronic coronary syndrome (CCS) after undergoing percutaneous coronary intervention (PCI).
- In a study of 830 patients, those who lived alone were younger and had similar comorbidities compared to those who did not.
- The findings showed that 24% of the living alone group experienced cardiac death, compared to only 11% of the non-living alone group, highlighting living alone as an independent risk factor for cardiac mortality.
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- The hepatic venous stasis index (HVSI) is proposed as a new measure for evaluating hepatic congestion in heart failure (HF) patients using abdominal ultrasonography.
- A study involving 513 HF patients showed that HVSI correlates with other cardiac function parameters and is linked to the severity of cardiac events.
- Higher HVSI levels were associated with worse prognosis, indicating that the index could serve as a significant marker for liver congestion and right-sided heart failure outcomes.
Background: Dilated cardiomyopathy (DCM) is a life-threatening disease related to heart failure. Extracellular matrix proteins have an important role in the pathogenesis of DCM. Latent transforming growth factor beta-binding protein 2 (LTBP-2), a type of extracellular matrix protein, has not been investigated in DCM.
View Article and Find Full Text PDFBackground: The present study aimed to clarify the regional variations in clinical practice and the prognosis of patients with heart failure with reduced ejection fraction (HFrEF) in Japan using the Japanese Registry of Acute Decompensated Heart Failure (JROADHF).
Methods and results: We recruited data of hospitalized patients with HFrEF (n=4,329) from the JROADHF. The patients were divided into 6 groups based on the region of Japan where they were hospitalized: Hokkaido-Tohoku (n=504), Kanto (n=958), Chubu (n=779), Kinki (n=902), Chugoku-Shikoku (n=446), and Kyushu (n=740).
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- Bleeding events are common in coronary artery disease (CAD) patients on antiplatelet therapy after percutaneous coronary intervention (PCI), and their impact on new cancer diagnoses is being studied.
- In a study of 1565 CAD patients, those who experienced any bleeding showed a higher incidence of new cancer diagnoses compared to those without bleeding events.
- Specifically, both any bleeding and minor bleeding events were linked to significantly higher rates of new cancer diagnoses, particularly gastrointestinal cancers, indicating that monitoring for bleeding could be essential in identifying cancer risks in these patients.
Introduction: The interaction between the heart and spleen plays a crucial role among cardiac and multiple organ networks, particularly in heart failure (HF). Ultrasound shear wave imaging is a non-invasive technology capable of quantifying tissue quality, but its significance in the spleen in patients with HF is poorly understood.
Methods And Results: This prospective observational study enrolled hospitalized 232 patients with HF undergoing abdominal ultrasonography.
Background: Blood pressure (BP) variability (BPV) is a predictor of cardiovascular outcomes independently of BP absolute values. We previously reported that pulse transit time (PTT) enables monitoring beat-to-beat BP, identifying a strong relationship between the extent of very short-term BPV and the severity of sleep-disordered breathing (SDB). Here, we investigated the effects of continuous positive airway pressure (CPAP) on very short-term BPV.
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- * Researchers categorized 348 patients into four groups based on whether they had hypochloremia during their hospitalizations and found that those with ongoing hypochloremia had the worst outcomes.
- * Results indicated that patients with persistent hypochloremia had significantly higher risks of all-cause and cardiac mortality, highlighting its importance as a prognostic indicator in heart failure.
D-dimer is a common measurable coagulation marker that is associated with the risk of thrombotic events in vascular diseases. However, the impact of D-dimer on long-term mortality in coronary artery disease (CAD) patients remains unclear. This study investigated the association between D-dimer and long-term all-cause, cardiac and cancer mortality in CAD patients.
View Article and Find Full Text PDFBackground: Kawasaki disease (KD) induces coronary arteritis, which causes subsequent coronary aneurysms, and contributes to acute myocardial infarction (AMI). However, the differences regarding real-world treatment selection and mortality between AMI-complicated KD and AMI due to typical atherosclerosis (AMI-non KD) are unknown.
Aim: The aim of the present study was to examine the current treatment strategy and prognosis of AMI-complicated KD compared with AMI due to typical atherosclerosis.
Background: The Patterns of non-Adherence to Anti-Platelet Regimen in Stented Patients (PARIS) thrombotic risk score has been proposed to estimate the risk of stent thrombotic events after percutaneous coronary intervention (PCI). However, the prognostic value of the PARIS thrombotic risk score for long term all-cause and cardiac mortalities, as well as hospitalization due to heart failure, has not yet been evaluated. Therefore, the aim of the present study was to evaluate the prognostic value of the PARIS thrombotic risk score for all-cause and cardiac mortalities and hospitalization due to heart failure following PCI.
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