Metal-centred azaphosphatriptycene gear with a photo- and thermally driven mechanical switching function based on coordination isomerism.

Metal ions can serve as a centre of molecular motions due to their coordination geometry, reversible bonding nature and external stimuli responsiveness. Such essential features of metal ions have been utilized for metal-mediated molecular machines with the ability to motion switch via metallation/demetallation or coordination number variation at the metal centre; however, motion switching based on the change in coordination geometry remain largely unexplored. Herein, we report a Pt-centred molecular gear that demonstrates control of rotor engagement and disengagement based on photo- and thermally driven cis-trans isomerization at the Pt centre.

Vascular-inducing poly(glycolic acid)-collagen nanocomposite-fiber scaffold.

For regenerative medicine with scaffolds, the immediate cellularization of the scaffold accompanied by angiogenesis inside is an important event. Such the aim is generally pursued by combining basic fibroblast growth factor (b-FGF) or vascular endothelial growth factor (VEGF) with the scaffold. In this study, we produced the nanocomposite nanofiber composed of poly(glycolic acid), PGA, and collagen to accomplish the recruitment of host cells and peripheral blood vessels without the bio-derived matter like growth factors.

[A case of type 4 advanced gastric cancer treated by S-1 simple suspension method with CDDP].

S-1 is a key drug for advanced, recurrent gastric cancer. It is difficult to administer S-1 for inoperable gastric cancer with stenosis. We report that a simple suspension method allows administration of S-1 for improved quality of life.

Controlled delivery of bFGF remodeled vascular network in muscle flap and increased perfusion capacity via minor pedicle.

Background: The vascular pedicles of superficial skeletal muscles are classified as the dominant pedicle and the minor pedicle. The dominant pedicle can reliably provide adequate circulation to the entire muscle, but the minor pedicle cannot. Therefore, it is impossible to elevate an entire muscle flap based solely on the minor pedicle.

Use of internal callus distraction in the treatment of congenital brachymetatarsia.

Congenital bilateral brachymetatarsia of the fourth metatarsal bone was treated by osteotomy and bone lengthening using the internal distraction technique. The patient was cosmetically improved. This technique has some advantages over the method of external distraction.

Induction of cell arrest by transfection of macrophage migration inhibitory factor antisense plasmid.

Macrophage migration inhibitory factor (MIF) is known to be a proinflammatory cytokine, glucocorticoid-induced immunomodulator. MIF is abundantly expressed in various cancer cells, and is considered to contribute to cell growth and differentiation. MIF inactivates the functions of wild-type p53.